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公开(公告)号：EP3848032A1
公开(公告)日：2021-07-14
申请号：EP19857755.3
申请日：2019-09-03
发明人： SHAO, Dong , SUN, Xinqiang , LAO, Xuejun , LIU, Wei , ZHANG, Weicai
IPC分类号： A61K31/4745 , A61P43/00
摘要： The present invention relates to an application of pyrroloquinoline quinone (PQQ) in the preparation of a medicament used for preventing and treating acute altitude sickness and acute altitude hypoxia injury. Pyrroloquinoline quinone has the effect of preventing and treating acute high altitude hypoxia injury, and as a drug for the prevention and treatment of acute altitude sickness, the efficacy thereof is equivalent to that of acetazolamide, however acetazolamide has many toxic side effects; meanwhile, as a coenzyme, pyrroloquinoline quinone has the advantages of low toxicity and is easily acceptance by patients. In addition, by means of exhaustive swimming experiments of mice under the conditions of hypoxic exposure, PQQ has been shown to have the feature characteristics of improving the working capabilities of a subject at a high altitude, however acetazolamide has not been found to have said effect.
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