公开(公告)号：EP4361144A1

公开(公告)日：2024-05-01

申请号：EP22827556.6

申请日：2022-06-21

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

发明人： ZHAO, Meiyu ,  CHEN, Lianwei ,  LI, Na ,  SHI, Zhenjuan ,  ZHENG, Jianfeng ,  SU, Di

IPC分类号： C07D403/12 ,  C07D471/10 ,  C07D487/10 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D471/10 ,  C07D487/10 ,  A61P35/00 ,  A61K31/506

摘要： The present invention relates to the field of chemical pharmacy, relates to a crystal form of a pyrimidine derivative and a preparation method therefor, and specifically relates to crystal forms A, B, C, D, and E of a compound of formula (I), a preparation method therefor, and a pharmaceutical composition and use thereof. The present invention solves the problems of small granularity, poor fluidity, poor stability and the like of the compound of formula (I) present in an amorphous form. The crystal form prepared by the present invention and the pharmaceutical composition thereof can be used for preparing a drug for treating a cancer disease.