公开(公告)号：EP3954680A1

公开(公告)日：2022-02-16

申请号：EP20786768.0

申请日：2020-04-09

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

发明人： ZHANG, Panpan ,  YAN, Sunli ,  LI, Ying ,  GUO, Chenli ,  QIAN, Wenjian ,  YE, Cheng ,  SHI, Zhengzheng ,  HU, Taishan ,  CHEN, Lei

IPC分类号： C07D401/14 ,  C07D403/04 ,  A61K31/506 ,  A61P35/00

摘要： The present invention relates to a piperazine amide derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and use of same as a therapeutic agent, especially as a selective Rearranged During Transfection (RET) kinase inhibitor. Ring a, ring e, X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , R 4 , R 4' , R 5 , R 5' , R 6 , R 6' , R 7 , R 7' , R 8 , m, and n have the same definitions as those in the specification.