公开(公告)号：EP3974434A1

公开(公告)日：2022-03-30

申请号：EP20809310.4

申请日：2020-05-20

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd. ,  Hisun Accuray Therapeutics Co., Ltd.

发明人： CHEN, Youxi ,  GONG, Liang ,  ZHU, Xingwu ,  XIANG, Qing ,  MAO, Wentao ,  YE, Cheng ,  HU, Taishan ,  CHEN, Lei ,  JIANG, Guoping

IPC分类号： C07D498/22 ,  C07D487/22 ,  C07D487/18 ,  A61K31/529 ,  A61K45/06 ,  A61P29/00 ,  A61P35/00 ,  A61P25/00 ,  A61P37/00

摘要： Provided are a macrolide derivative represented by formula (I), a preparation method thereof, and an application of the macrolide derivative as an inhibitor of one or more protein kinases of TRK, ALK and ROS1,