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公开(公告)号：EP3196185B1
公开(公告)日：2019-06-12
申请号：EP15842631.2
申请日：2015-04-28
发明人： YAN, Pucha , LI, Yuanqiang , CHE, Daqing , ZHANG, Xiangdong , CHEN, Kang , YAN, Yongliang
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公开(公告)号：EP3196185A1
公开(公告)日：2017-07-26
申请号：EP15842631.2
申请日：2015-04-28
发明人： YAN, Pucha , LI, Yuanqiang , CHE, Daqing , ZHANG, Xiangdong , CHEN, Kang , YAN, Yongliang
IPC分类号： C07C51/367 , C07C59/50 , C07C59/56 , C07C59/48 , C07C59/64 , C07C59/11 , C07C59/01 , C07F9/58 , B01J31/24
CPC分类号： C07C51/367 , B01J31/1815 , B01J31/189 , B01J31/2447 , B01J2231/643 , B01J2531/0241 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C59/01 , C07C59/11 , C07C59/48 , C07C59/50 , C07C59/56 , C07C59/64 , C07C2601/14 , C07F9/58
摘要： The present invention relates to the technical field of organic chemistry, specifically an asymmetrical hydrogenation of an α-ketonic acid compound, the technical proposal being as shown by the following formula:
Wherein R 1 is a phenyl, a substituted phenyl, a naphthyl, a substituted naphthyl, a C 1 -C 6 alkyl or aralkyl, the substitute is a C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a halogen, the number of the substituents is 1-3.
M is a chiral spiro-pyridyl amido phosphine ligand iridium complex having the following structure,
Wherein, R is hydrogen, 3-methyl, 4- t Bu or 6-methyl.摘要翻译： 本发明涉及有机化学技术领域，具体涉及α-酮酸化合物的不对称氢化，其技术方案如下式所示：其中，R1为苯基，取代的苯基，萘基，取代的 萘基，C1-C6烷基或芳烷基，取代基为C1-C6烷基，C1-C6烷氧基，卤素，取代基的数目为1-3。 M为具有以下结构的手性螺 - 吡啶基酰胺膦配体铱配合物，其中R为氢，3-甲基，4-tBu或6-甲基。
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