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    BISPECIFIC HER2 AND HER3 ANTIGEN BINDING CONSTRUCTS
    1.
    发明公开
    BISPECIFIC HER2 AND HER3 ANTIGEN BINDING CONSTRUCTS 审中-公开
    BISPEZIFISCHE HER2- UND HER3-ANTIGENBINDENDE KONSTRUKTE

    公开(公告)号：EP2994164A1

    公开(公告)日：2016-03-16

    申请号：EP14794897.0

    申请日：2014-05-08

    申请人： Zymeworks, Inc.

    发明人： NG, Gordon, Yiu Kon ,  CHAN, Peter, Wing Yiu ,  WICKMAN, Grant, Raymond

    IPC分类号： A61K39/395

    摘要： Described herein are isolated bi-specific antigen binding constructs, e.g., antibodies. The bi-specific antigen binding constructs include two antigen binding polypeptide constructs, e.g., a Fab and an scFv. The first antigen-binding polypeptide construct monovalently and specifically binds to extracellular domain 4 (ECD4) of HER2 (human epidermal growth factor receptor 2); the second antigen-binding polypeptide construct monovalently and specifically binds to an extracellular domain (ECD) of HER3 (human epidermal growth factor receptor 3). One antigen binding polypeptide construct is a Fab format and the other antigen binding polypeptide construct is an scFv format. The bi-specific antigen binding constructs includes an Fc having two Fc polypeptides each having a CH3 domain for dimerization. Each Fc polypeptide is linked to the C-terminus of one of the antigen binding polypeptide constructs with or without a linker.

    摘要翻译： 本文描述的是分离的双特异性抗原结合构建体，例如抗体。 双特异性抗原结合构建体包括两个抗原结合多肽构建体，例如Fab和scFv。 第一抗原结合多肽构建物与HER2（人表皮生长因子受体2）的细胞外结构域4（ECD4）单价并特异性结合; 第二抗原结合多肽构建物单独且特异性结合HER3（人表皮生长因子受体3）的细胞外结构域（ECD）。 一个抗原结合多肽构建体是Fab格式，另一个抗原结合多肽构建体是scFv格式。 双特异性抗原结合构建体包括具有两个Fc多肽的Fc，每个Fc多肽具有用于二聚化的CH3结构域。 每个Fc多肽与具有或不具有接头的抗原结合多肽构建体之一的C-末端连接。