专利检索 ap:("Zymeworks Inc.") AND inv:"NG, Gordon YiuKon" 第 1 页

1.

发明授权
HETEROMULTIMER CONSTRUCTS OF IMMUNOGLOBULIN HEAVY CHAINS WITH MUTATIONS IN THE FC DOMAIN 有权

公开(公告)号：EP2847230B1

公开(公告)日：2020-08-12

申请号：EP13788302.1

申请日：2013-05-10

申请人： Zymeworks Inc.

发明人： SPRETER VON KREUDENSTEIN, Thomas , ESCOBAR-CABRERA, Eric , NG, Gordon YiuKon , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , POON, David Kai Yuen

IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , A61P37/02 , C07K16/12 , C07K16/24 , C07K16/28 , C07K16/30

2.

发明公开
HETEROMULTIMER CONSTRUCTS OF IMMUNOGLOBULIN HEAVY CHAINS WITH MUTATIONS IN THE FC DOMAIN 审中-公开
标题翻译： HETEROMULTIMERKONSTRUKTE严重的免疫球蛋白在FC结构域的突变

公开(公告)号：EP2847230A1

公开(公告)日：2015-03-18

申请号：EP13788302.1

申请日：2013-05-10

申请人： Zymeworks, Inc.

发明人： SPRETER VON KREUDENSTEIN, Thomas , ESCOBAR-CABRERA, Eric , NG, Gordon YiuKon , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , POON, David Kai Yuen

IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , A61P37/02 , C07K16/12 , C07K16/24 , C07K16/28 , C07K16/30

摘要： Provided herein are isolated heteromultimers comprising: at least one single domain antigen-binding construct attached to at least one monomer of a heterodimer Fc region; wherein the heterodimer Fc region comprises a variant CH3 domain comprising amino acid mutations that promote the formation of said heterodimer with stability comparable to that of a native Fc homodimer; and wherein said isolated heteromultimer is devoid of immunoglobulin light chains and optionally devoid of immunoglobulin CH1 region. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.