专利检索 ap:("Zymeworks Inc.") AND inv:"TOM-YEW, Stacey A.L." 第 1 页

1.

发明公开
ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS COMPRISING KAPPA AND LAMBDA LIGHT CHAINS AND USES THEREOF 审中-公开

公开(公告)号：EP3359576A1

公开(公告)日：2018-08-15

申请号：EP16852954.3

申请日：2016-10-07

申请人： Zymeworks Inc.

发明人： UROSEV, Dunja , SANCHES, Mario , TOM-YEW, Stacey A.L. , PRESTA, Leonard G.

IPC分类号： C07K16/46 , A61K39/395 , C07K16/00 , C12N15/13 , C12N15/63 , C12P21/00

CPC分类号： C07K16/46 , C07K16/244 , C07K16/32 , C07K16/468 , C07K2299/00 , C07K2317/21 , C07K2317/31 , C07K2317/515 , C07K2317/55 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C12N15/63 , C12P21/00

摘要： Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. The amino acid modifications may be in the CH1 and/or CL domains, in the VH and/or VL domains, or a combination thereof.