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公开(公告)号：EP3214095A1
公开(公告)日：2017-09-06
申请号：EP16192149.9
申请日：2006-05-12
申请人： ZymoGenetics, Inc.
发明人： LEVIN, Steven D. , BILSBOROUGH, Janine , WEST, James W. , BRANDT, Cameron , RAMSDELL, Frederick J. , HOWARD, Edward D. , CHADWICK, Eric M. , GAO, Zeren
IPC分类号： C07K14/705 , C07K16/28 , C12N15/62 , A61K38/17 , G01N33/50 , A61K38/00 , C07K14/47 , C12Q1/66 , G01N33/569 , A61K39/00
摘要： There is provided a newly identified B7 receptor, zB7R1, which functions as lymphocyte inhibitory receptor. zB7R1 is a PD-1-like molecule expressed on T cells, and is able to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signalling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic, and research purposes are also provided.
摘要翻译： 提供了新发现的B7受体zB7R1，其功能为淋巴细胞抑制性受体。 zB7R1是在T细胞上表达的PD-1样分子，能够与CD155结合。 还提供了用于调节zB7R1介导的负信号传导并干扰其反受体相互作用以用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：EP3683230A1
公开(公告)日：2020-07-22
申请号：EP19207208.0
申请日：2006-05-12
申请人： ZymoGenetics, Inc.
发明人： LEVIN, Steven D. , BILSBOROUGH, Janine , WEST, James W. , BRANDT, Cameron , RAMSDELL, Frederick J. , HOWARD, Edward D. , CHADWICK, Eric M. , GAO, Zeren
IPC分类号： C07K14/705 , C07K16/28 , C12N15/62 , A61K38/17
摘要： The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
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公开(公告)号：EP3214095B1
公开(公告)日：2019-12-11
申请号：EP16192149.9
申请日：2006-05-12
申请人： ZymoGenetics, Inc.
发明人： LEVIN, Steven D. , BILSBOROUGH, Janine , WEST, James W. , BRANDT, Cameron , RAMSDELL, Frederick J. , HOWARD, Edward D. , CHADWICK, Eric M. , GAO, Zeren
IPC分类号： C07K14/705 , C07K16/28 , C12N15/62 , A61K38/17 , G01N33/50 , A61K38/00 , C07K14/47 , C12Q1/66 , G01N33/569 , A61K39/00
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