公开(公告)号：EP2274008B1

公开(公告)日：2014-02-26

申请号：EP09724060.0

申请日：2009-03-27

申请人： ZymoGenetics, Inc.

发明人： SIVAKUMAR, Pallavur V. ,  GILBERTSON, Debra G. ,  SNAVELY, Marshall D. ,  MABRY, George R. ,  YI, Eugene C. ,  YAO, Yue ,  PRESNELL, Scott R.

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/22 ,  C07K16/28

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/90 ,  C07K2317/92

摘要： There is provided an isolated antibody that binds to the extracellular domain of PDGFR² and neutralizes PDGFR² activity, said antibody comprising a V L domain comprising CDRs LCDR1, LCDR2, and LCDR3 and a V H domain comprising CDRs HCDR1, HCDR2, and HCDR3, wherein: LCDR1 has the amino acid sequence shown in SEQ ID NO: 433, optionally the amino acid sequence shown in SEQ ID NO: 443; LCDR2 has the amino acid sequence shown in SEQ ID NO: 434; LCDR3 has the amino acid sequence shown in SEQ ID NO: 435, optionally the amino acid sequence shown in SEQ ID NO: 444; HCDR1 has the amino acid sequence shown in SEQ ID NO: 436, optionally the amino acid sequence shown in SEQ ID NO: 445; HCDR2 has the amino acid sequence shown in SEQ ID NO: 437; HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 438-442