公开(公告)号：EP4355353A1

公开(公告)日：2024-04-24

申请号：EP22732547.9

申请日：2022-06-10

申请人： advanceCOR GmbH

发明人： MÜNCH, Götz ,  ADLER, Kristin ,  GAWAZ, Meinrad

IPC分类号： A61K38/17 ,  A61P9/10 ,  C07K16/00 ,  G01N33/68 ,  A61K9/00 ,  A61K39/00 ,  A61P7/02

CPC分类号： A61P9/10 ,  A61K38/177 ,  A61K38/1774 ,  G01N2800/5220130101 ,  A61P7/02 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/26

公开(公告)号：EP2556092A1

公开(公告)日：2013-02-13

申请号：EP11712780.3

申请日：2011-04-06

申请人： advanceCOR GmbH

发明人： GAWAZ, Meinrad ,  SCHÖNBERGER, Tanja ,  DEGEN, Heidrun ,  MÜNCH, Götz ,  HOLTHOFF, Hans-Peter ,  BÜLTMANN, Andreas ,  BÜHRING, Hans-Jörg ,  LEDER, Christoph

IPC分类号： C07K16/28

CPC分类号： C07K16/2896 ,  C07K14/705 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/70

摘要： An isolated nucleic acid molecule selected from the group consisting of: vi. a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of SEQ ID NO:1 or a complement thereof; vii. a nucleic acid molecule comprising a fragment of at least 1500 consecutive nucleotides of the nucleotide sequence of SEQ ID NO:1, or a complement thereof; viii. a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 85% identical to SEQ ID NO:2; ix. a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 500 contiguous amino acids of SEQ ID NO: 2; and x. a nucleic acid molecule encoding a polypeptide containing a humanized immunoglobulin or parts of an immunoglubulin having binding specificity for CD133 a nucleic acid molecule which encodes a variant of a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising the entire SEQ ID NO: 1, or complement thereof under conditions of incubation at 45 °C in 6.0xSSC followed by washing in 0.2xSSC/0.1% SDS at 65 °C.