公开(公告)号：EP4225759A1

公开(公告)日：2023-08-16

申请号：EP21786956.9

申请日：2021-10-05

申请人： biolitec Unternehmensbeteiligungs II AG ,  FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

发明人： ALBRECHT, Volker ,  VON BRIESEN, Hagen ,  SCHEGLMANN, Dietrich ,  GITTER, Burkhard ,  WIEHE, Arno ,  WAGNER, Sylvia ,  GERMANN, Anja ,  STEEN, Dorika ,  WIELAND, Gerhard

IPC分类号： C07D487/22 ,  A61K31/555 ,  A61P31/04 ,  A61P31/12

公开(公告)号：EP2051699B1

公开(公告)日：2018-09-26

申请号：EP07776843.0

申请日：2007-05-08

申请人： biolitec Unternehmensbeteiligungs II AG

发明人： FARMER, Gerard ,  SCHEGLMANN, Dietrich ,  ALBRECHT, Volker ,  NIFANTIEV, Nikolay, E.

IPC分类号： A61K9/127 ,  A61K41/00 ,  A61K9/00

CPC分类号： A61K9/127 ,  A61K9/0014 ,  A61K41/0071

摘要： Highly flexible penetrating liposomal carrier systems are formulated with enhanced skin penetration properties. These specialized formulations of highly flexible penetrating liposomal delivery systems comprise one or more phospholipids, lysophosphatides and hydrophobic photosensitizer. This new formulations can squeeze liposomal particles through intercellular regions of stratum corneum as intact structures, and, in this way, deliver encapsulated photosensitizer to the epidermis, dermis, hypodermis and surroundings. The penetrating liposomal formulation provides therapeutically effective amounts of the hydrophobic photosensitizer through topical application with better skin penetration thus improving drug targeting and the efficacy of photodynamic therapy (PDT).