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公开(公告)号：EP0135337B1
公开(公告)日：1989-07-19
申请号：EP84305342.2
申请日：1984-08-06
申请人： Bellex Corporation
发明人： Inada, Yuji
IPC分类号： A61K31/575
CPC分类号： A61K31/575
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公开(公告)号：EP0260098A3
公开(公告)日：1988-07-27
申请号：EP87307898
申请日：1987-09-07
申请人： Bellex Corporation
CPC分类号： G01N33/54353 , C12N9/82 , C12N11/08 , C12N11/14 , C12P1/00 , G01N33/5434 , G01N2446/20 , G01N2446/30 , G01N2446/86
摘要： Disclosed is a conjugate comprising a magnetic material and a physiologically active substance bound to each other through a polyethylene glycol derivative, and a conjugate comprising a magnetic material and a polyethylene glycol derivative bound to each other. According to the present invention, a bioreactor enabling application to or recovery of physiologically active substances under liquid state by utilizing the magnetic properties is provided.
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公开(公告)号：EP0149520A3
公开(公告)日：1987-11-25
申请号：EP85300102
申请日：1985-01-07
申请人： Bellex Corporation
发明人： Inada, Yuji
CPC分类号： C12P7/6436 , C07J9/00 , C12N9/20 , C12N9/96 , C12N11/08
摘要： A modified lipase, comprising lipase molecules which are partially substituted with an active derivative of a polyalkylene glycol having a hydrophobic group at the terminal end.
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4.发明公开Modified haem, process for its production and use 失效ModifiziertesHäm，Verfahren zu seiner Herstellung und Verwendung。
公开(公告)号：EP0232857A2
公开(公告)日：1987-08-19
申请号：EP87101555.8
申请日：1987-02-05
IPC分类号： C07D487/22 , G01N33/00 , G01N33/02 , G01N33/52
CPC分类号： C07D487/22 , C12Q1/28
摘要： The invention provides a modified haem which is chemically coupled with a polyalkylene glycol methyl ether or an ω-amino derivative thereof through at least one of the two carboxyl groups in said haem molecule. The modified haem has a peroxidase activity and is soluble in water or various organic solvents. It can be used for detecting peroxides in samples such as blood, food or cosmetics. A process for the production of the modified haem is also disclosed.
摘要翻译： 本发明提供了通过所述血红素分子中的两个羧基中的至少一个与聚亚烷基二醇甲基醚或其ω-氨基衍生物化学偶联的改性血红素。 改性的血红素具有过氧化物酶活性，可溶于水或各种有机溶剂。
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公开(公告)号：EP0149520B1
公开(公告)日：1991-09-04
申请号：EP85300102.2
申请日：1985-01-07
申请人： Bellex Corporation
发明人： Inada, Yuji
CPC分类号： C12P7/6436 , C07J9/00 , C12N9/20 , C12N9/96 , C12N11/08
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公开(公告)号：EP0149520A2
公开(公告)日：1985-07-24
申请号：EP85300102.2
申请日：1985-01-07
申请人： Bellex Corporation
发明人： Inada, Yuji
CPC分类号： C12P7/6436 , C07J9/00 , C12N9/20 , C12N9/96 , C12N11/08
摘要： A modified lipase, comprising lipase molecules which are partially substituted with an active derivative of a polyalkylene glycol having a hydrophobic group at the terminal end.
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7.发明公开Preventive and curative preparation for thrombosis 失效Präventiveund heilendePräparategegen Thrombose。
公开(公告)号：EP0135337A2
公开(公告)日：1985-03-27
申请号：EP84305342.2
申请日：1984-08-06
申请人： Bellex Corporation
发明人： Inada, Yuji
IPC分类号： A61K31/575
CPC分类号： A61K31/575
摘要： Disclosed is a preventive and curative preparation for thrombosis, which comprises a pharmaceutically effective amount of a plant sterol selected from the group consisting of sitosterol and fucosterol, and a pharmaceutically acceptable carrier. Also disclosed is a method of treating the thrombosis.
摘要翻译： 公开了用于血栓形成的预防和治疗性制剂，其包含药学有效量的选自谷甾醇和岩藻甾醇的植物甾醇和药学上可接受的载体。 还公开了治疗血栓形成的方法。
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公开(公告)号：EP0232857A3
公开(公告)日：1989-07-26
申请号：EP87101555.8
申请日：1987-02-05
IPC分类号： C07D487/22 , G01N33/00 , G01N33/02 , G01N33/52
CPC分类号： C07D487/22 , C12Q1/28
摘要： The invention provides a modified haem which is chemically coupled with a polyalkylene glycol methyl ether or an ω-amino derivative thereof through at least one of the two carboxyl groups in said haem molecule. The modified haem has a peroxidase activity and is soluble in water or various organic solvents. It can be used for detecting peroxides in samples such as blood, food or cosmetics. A process for the production of the modified haem is also disclosed.
摘要翻译： 本发明提供了通过所述血红素分子中的两个羧基中的至少一个与聚亚烷基二醇甲基醚或其ω-氨基衍生物化学偶联的改性血红素。 改性的血红素具有过氧化物酶活性，可溶于水或各种有机溶剂。
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9.发明公开Magnetic material-physiologically active substance conjugate 失效Konjugat von physiologisch aktivem Stoff und magnetischem材料。
公开(公告)号：EP0260098A2
公开(公告)日：1988-03-16
申请号：EP87307898.4
申请日：1987-09-07
申请人： Bellex Corporation
CPC分类号： G01N33/54353 , C12N9/82 , C12N11/08 , C12N11/14 , C12P1/00 , G01N33/5434 , G01N2446/20 , G01N2446/30 , G01N2446/86
摘要： Disclosed is a conjugate comprising a magnetic material and a physiologically active substance bound to each other through a polyethylene glycol derivative, and a conjugate comprising a magnetic material and a polyethylene glycol derivative bound to each other.
According to the present invention, a bioreactor enabling application to or recovery of physiologically active substances under liquid state by utilizing the magnetic properties is provided.摘要翻译： 公开了包含通过聚乙二醇衍生物彼此结合的磁性材料和生理活性物质的共轭物，以及包含彼此结合的磁性材料和聚乙二醇衍生物的共轭物。 根据本发明，提供了一种利用磁性能使液体状态下能够应用或回收生理活性物质的生物反应器。
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10.发明公开Preventive and curative preparation for thrombosis and method of treating the same 失效用于血栓形成的预防和治疗准备及其治疗方法
公开(公告)号：EP0135337A3
公开(公告)日：1985-07-31
申请号：EP84305342
申请日：1984-08-06
申请人： Bellex Corporation
发明人： Inada, Yuji
IPC分类号： A61K31/575
CPC分类号： A61K31/575
摘要： Disclosed is a preventive and curative preparation for thrombosis, which comprises a pharmaceutically effective amount of a plant sterol selected from the group consisting of sitosterol and fucosterol, and a pharmaceutically acceptable carrier. Also disclosed is a method of treating the thrombosis.
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