公开(公告)号：EP3169312B1

公开(公告)日：2020-09-02

申请号：EP15822181.2

申请日：2015-07-17

申请人： BioCurity Pharmaceuticals Inc.

发明人： BAKER, Cheryl

IPC分类号： A61K9/14 ,  A61K33/24 ,  A61P35/00 ,  A61K31/7068 ,  A61K31/337 ,  A61K9/00 ,  A61K9/107 ,  A61K45/06

公开(公告)号：EP3628308A1

公开(公告)日：2020-04-01

申请号：EP19207165.2

申请日：2015-07-17

申请人： BioCurity Pharmaceuticals Inc.

发明人： BAKER, Cheryl

IPC分类号： A61K9/14 ,  A61K33/24 ,  A61P35/00 ,  A61K31/7068 ,  A61K31/337 ,  A61K9/00 ,  A61K9/107 ,  A61K45/06

摘要： The present invention is directed to methods for the treatment of cancer with a combination of radiation, cerium oxide nanoparticles and at least one chemotherapeutic agent. Cerium oxide nanoparticles (CONPs) are nanometer-sized crystals of cerium oxide, typically ranging between about one nanometer to about 20 nanometers in longest dimension. The present methods use cerium oxide nanoparticles to enhance radiation-induced and chemotherapy-induced cancer cell death and also reduce the toxicity associated with radiation therapy and chemotherapy