-
公开(公告)号：EP1789803B1
公开(公告)日：2010-07-14
申请号：EP05789386.9
申请日：2005-09-08
IPC分类号： G01N33/68
CPC分类号： C07K16/26 , C07K2317/34 , G01N33/68 , G01N2333/58 , G01N2800/32
-
公开(公告)号：EP1789803A2
公开(公告)日：2007-05-30
申请号：EP05789386.9
申请日：2005-09-08
IPC分类号： G01N33/68
CPC分类号： C07K16/26 , C07K2317/34 , G01N33/68 , G01N2333/58 , G01N2800/32
摘要： The invention relates to a method for identifying feline or canine proBNP or fragments thereof, which comprises the following steps: providing a feline or canine sample, contacting the sample with at least one antibody which binds, when feline proBNP or fragments thereof are identified, to at least one epitope in the area comprising amino acids 20 to 42 and/or in the area comprising amino acids 57 to 80 of the feline proBNP, and which binds, when canine proBNP or fragments thereof are identified, to at least one epitope in the area comprising amino acids 20 to 68 of the canine proBNP, and identifying the presence and/or concentration of the feline or canine proBNP or fragments thereof in the sample.
-
3.发明公开
公开(公告)号：EP2267455A2
公开(公告)日：2010-12-29
申请号：EP10183988.4
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
摘要翻译： 提供了预测患有充血性心力衰竭的个体的生存结果的方法。 根据该方法，通过考虑两种标记物组合的水平来确定患者的存活结果，所述组合比单独的标记更可预测存活。 标志物包括内皮素，心房钠尿肽和脑钠肽，其前体及其片段。 使用本发明的方法鉴定为具有增加的死亡风险的患有充血性心力衰竭的个体适当地针对更积极的治疗。
-
公开(公告)号：EP2264463A3
公开(公告)日：2011-08-10
申请号：EP10183974.4
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
-
公开(公告)号：EP1756583B1
公开(公告)日：2010-10-27
申请号：EP05757019.4
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriuretic peptide and brain natriuretic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
-
公开(公告)号：EP2060920A1
公开(公告)日：2009-05-20
申请号：EP07450202.2
申请日：2007-11-19
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/26 , G06F19/00
摘要： The invention describes a method for diagnosing of septic complications in patients by determining the level of the C-type natriuretic peptide (CNP), its precursors or fragments thereof, especially the precursor of the C-type natriuretic peptide (NT-proCNP), in this patient and diagnosing the patient a having septic complications or being at risk of developing septic complications, if the level of CNP, its precursors or fragments thereof, especially NT-proCNP, is increased compared to normal levels.
摘要翻译： 本发明描述了通过确定C型利尿钠肽（CNP），其前体或其片段，特别是C型利尿钠肽（NT-proCNP）的前体的水平来诊断患者的败血症并发症的方法， 如果CNP，其前体或其片段，特别是NT-proCNP的水平与正常水平相比增加，则该患者并诊断患有脓毒性并发症或具有发生脓毒性并发症风险的患者。
-
公开(公告)号：EP2118665B1
公开(公告)日：2012-04-18
申请号：EP08714279.0
申请日：2008-03-06
IPC分类号： G01N33/68
CPC分类号： G01N33/56911 , G01N33/74 , G01N2333/58 , G01N2800/26
摘要： The invention describes a method for diagnosing of septic complications in polytraumatised human or animal patients, said patients being free of traumatic brain injury, by determining the level of the C-type natriuretic peptide (CNP), its precursors or fragments thereof, especially the precursor of the C-type natriuretic peptide (NT-proCNP), in this patient and diagnosing the patient a having septic complications or being at risk of developing septic complications, if the level of CNP, its precursors or fragments thereof, especially NT-proCNP, is increased compared to normal levels.
-
公开(公告)号：EP2264463A2
公开(公告)日：2010-12-22
申请号：EP10183974.4
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
摘要翻译： 提供了用于预测患有充血性心力衰竭的个体的存活结果的方法。 根据该方法，通过考虑两种标志物组合的水平来确定患者的存活结果，该组合比单独的任一标志物更能预测存活。 标记物包括内皮素，心房钠尿肽和脑尿钠肽，它们的前体及其片段。 使用本发明的方法鉴定具有增加的死亡风险的充血性心力衰竭患者适合用于更积极的治疗。
-
公开(公告)号：EP2118668A1
公开(公告)日：2009-11-18
申请号：EP08714281.6
申请日：2008-03-07
CPC分类号： G01N33/74 , C07K14/58 , C07K16/26 , C07K2317/34 , G01N2333/58 , G01N2800/324 , G01N2800/325
摘要： The invention relates to a method of determining equine NT-proBNP, or fragments thereof, comprising the steps of : providing an equine sample, contacting the sample with at least one antibody which specifically binds to equine NT-proBNP, and determining the presence and/or concentration of the equine NT-proBNP or fragments thereof existing in the sample.
-
公开(公告)号：EP2267455A3
公开(公告)日：2012-01-04
申请号：EP10183988.4
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.012 秒)
