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公开(公告)号：EP3486243B1
公开(公告)日：2020-04-15
申请号：EP18206553.2
申请日：2018-11-15
申请人： Bioprojet
发明人： BERREBI-BERTRAND, Isabelle , BILLOT, Xavier , CALMELS, Thierry , CAPET, Marc , KRIEF, Stéphane , LABEEUW, Olivier , LECOMTE, Jeanne-Marie , LEVOIN, Nicolas , LIGNEAU, Xavier , ROBERT, Philippe , SCHWARTZ, Jean-Charles
IPC分类号： C07D401/12 , A61K31/4439 , A61P37/08
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2.发明公开
公开(公告)号：EP3378858A1
公开(公告)日：2018-09-26
申请号：EP17305310.9
申请日：2017-03-21
申请人： Bioprojet
IPC分类号： C07D401/12 , A61K31/4545
CPC分类号： C07D401/12 , C07B2200/13
摘要： The present invention concerns the tetrahydrate form of the compound: (3 S )-4-{4-[3-(3-methylpiperidin-1-yl)propoxy]phenyl}pyridine 1-oxide, dihydrochloride, its process of preparation and therapeutical uses thereof.
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3.发明授权UTILISATION D'UN INHIBITEUR DE VASOPEPTIDASE POUR LE TRAITEMENT DE L'HYPERTENSION ARTERIELLE PULMONAIRE 有权USING A血管肽酶抑制剂，其用于治疗肺动脉高压
公开(公告)号：EP2026796B1
公开(公告)日：2016-11-09
申请号：EP07788875.8
申请日：2007-06-12
申请人： BIOPROJET
IPC分类号： A61K31/36 , A61K31/519 , A61K45/06 , A61P9/12
CPC分类号： A61K31/36 , A61K31/519 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2038268B1
公开(公告)日：2015-11-04
申请号：EP07766572.7
申请日：2007-06-21
申请人： BIOPROJET
发明人： CAPET, Marc , DANVY, Denis , LEVOIN, Nicolas , BERREBI-BERTRAND, Isabelle , CALMELS, Thierry , ROBERT, Philippe , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles , LIGNEAU, Xavier
IPC分类号： C07D295/12 , A61K31/495 , A61P25/00 , C07D211/26 , C07D295/14 , C07D295/10 , C07D307/24 , C07D211/70 , C07D211/60 , C07D213/74 , C07D217/02 , C07D239/42 , C07D215/40
CPC分类号： C07D213/74 , C07D211/26 , C07D211/60 , C07D211/70 , C07D215/40 , C07D217/02 , C07D239/42 , C07D295/10 , C07D295/112 , C07D295/135 , C07D295/14 , C07D295/155 , C07D307/24
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公开(公告)号：EP2697219A1
公开(公告)日：2014-02-19
申请号：EP12714674.4
申请日：2012-04-10
发明人： CAPET, Marc , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , THENNATI, Rajamannar , PAL, Ranjan, Kumar , SAMANTA, Biswajit , PILLAI, Muthukumaran, Natarajan , DESAI, Japan, Nitinkumar , RANA, Dijixa, Chandubhai , PRAJAPATI, Kaushik, Dhanjubhai , PATHAK, Sandeep, Pankajbhai , PANCHAL, Bhavesh, M. , ARADHYE, Jayraj, D.
IPC分类号： C07D413/10 , A61K31/454 , A61P9/10 , A61P29/00 , A61P37/06 , A61P35/00 , C07D413/14 , A61K31/5377
CPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06
摘要： The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.
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6.发明公开Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications 有权新颖（氮杂）Benzhydryletherderivate，它们的制备方法和它们作为H 4受体配体的治疗应用中使用
公开(公告)号：EP2671871A1
公开(公告)日：2013-12-11
申请号：EP13170687.1
申请日：2013-06-05
申请人： BIOPROJET
发明人： Berrebi-Bertrand, Isabelle , Billot, Xavier , Calmels, Thierry , Capet, Marc , Krief, Stéphane , Labeeuw, Olivier , Lecomte, Jeanne-Marie , Levoin, Nicolas , Ligneau, Xavier , Robert, Philippe , Schwartz, Jean-Charles
IPC分类号： C07D211/46 , C07D401/12 , A61K31/4545 , A61K31/445 , A61P11/00 , A61P9/00 , A61P17/00
CPC分类号： C07D401/12 , A61K31/445 , A61K31/4545 , A61K45/06 , C07D211/22 , C07D211/46
摘要： The present invention concerns novel (aza)benzhydryl ether derivatives which exhibit H4-receptor binding activity. The present invention also concerns their process of preparation and their therapeutical uses.
摘要翻译： 本发明涉及新的（氮杂）二苯甲基醚衍生物，哪个H4受体的结合活性。 因此，本发明涉及它们的它们的治疗用途的制备方法和。
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公开(公告)号：EP2038268A2
公开(公告)日：2009-03-25
申请号：EP07766572.7
申请日：2007-06-21
申请人： BIOPROJET
发明人： CAPET, Marc , DANVY, Denis , LEVOIN, Nicolas , BERREBI-BERTRAND, Isabelle , CALMELS, Thierry , ROBERT, Philippe , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles , LIGNEAU, Xavier
IPC分类号： C07D295/12 , A61K31/495 , A61P25/00 , C07D211/26 , C07D295/14 , C07D295/10 , C07D307/24 , C07D211/70 , C07D211/60 , C07D213/74 , C07D217/02 , C07D239/42 , C07D215/40
CPC分类号： C07D213/74 , C07D211/26 , C07D211/60 , C07D211/70 , C07D215/40 , C07D217/02 , C07D239/42 , C07D295/10 , C07D295/112 , C07D295/135 , C07D295/14 , C07D295/155 , C07D307/24
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
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8.发明公开Novel dicarboxylic acid derivatives as S1P1 receptor agonists 审中-公开NeueDicarbonsäurederivateals S1P1 Rezeptor Agonisten
公开(公告)号：EP2014653A1
公开(公告)日：2009-01-14
申请号：EP07290748.8
申请日：2007-06-15
发明人： Capet, Marc , Levoin, Nicolas , Berrebi-Bertrand, Isabelle , Robert, Philippe , Schwartz, Jean-Charles , Lecomte, Jeanne-Marie , Aradhye, Jayraj Dilipbhai , Pillai, Muthukumaran Natarajan, C/106, Shantivan society , Panchal, Bhavesh Mohanbhai , Jivani, Jignesh Kantilal , Samanta, Biswajit , Pal, Ranjan Kumar, A/4 Shreeji Park Duplex-Opp. , Thennati, Rajamannar
IPC分类号： C07D271/06 , C07D413/10 , C07D413/14 , A61K31/4245 , A61P29/00 , A61P37/06
CPC分类号： C07D413/10 , C07D271/06 , C07D413/14
摘要： The present invention provides a novel class of 3-phenyl or 5-phenyl-1,2,4-oxadiazole based dicarboxylic acid derivatives useful as S1P1 receptor agonists, their process of preparation and their therapeutic use.
摘要翻译： 本发明提供了一类新的可用作S1P1受体激动剂的3-苯基或5-苯基-1,2,4-恶二唑基二羧酸衍生物，其制备方法及其治疗用途。
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公开(公告)号：EP1042288B1
公开(公告)日：2007-11-07
申请号：EP98966427.1
申请日：1998-12-23
发明人： SCHWARTZ, Jean-Charles , ROSE, Christiane , VARGAS, Froylan, Nathan SmithKline Instit. Neuroch , GANELLIN, Charon, Robin , ZHAO, Lihua , SAMAD, Sanjeeda , CHEN, Yongjun
IPC分类号： C07D209/42 , A61K31/40 , C07D209/60 , C07D491/04
CPC分类号： C07D209/42
摘要： The invention is relative to a compound of formula (I), wherein R?1, R2, R3¿ and n are as defined, together with a process for its preparation. The invention is also relative to the use of a compound (I) as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the treatment of eating disorder, obesity, psychotic syndromes and associated psychiatric disorders. It concerns also the cosmetic use of a compound (I) in particular to aid slimming.
摘要翻译： 本发明涉及其中R 1，R 2，R 3和n如上所定义的式（I）化合物及其制备方法。 本发明还涉及化合物（I）作为CCK灭活肽酶三肽基肽酶（TPP II）的抑制剂的用途。 本发明特别涉及进食障碍，肥胖症，精神病综合征和相关精神障碍的治疗。 它还涉及化合物（I）的化妆品用途，特别是用于帮助减肥。
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10.发明公开Treatment of epilepsy with non-imidazole alkylamines histamine H3-receptor ligands 审中-公开烷基胺的使用不含有咪唑作为组胺H3受体配体，用于治疗癫痫症
公开(公告)号：EP1707204A1
公开(公告)日：2006-10-04
申请号：EP05290728.4
申请日：2005-04-01
申请人： BIOPROJET
IPC分类号： A61K31/4453 , A61P25/08
CPC分类号： A61K31/4453
摘要： The present invention provides new method of treatment of epilepsy with non-imidazole alkylamine derivatives that constitute antagonists of the H 3 -receptors of histamine.
摘要翻译： 本发明提供了治疗癫痫的方法，新的与非咪唑烷基胺衍生物也构成组胺H 3 - 受体的拮抗剂。
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