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公开(公告)号：EP2895155A1
公开(公告)日：2015-07-22
申请号：EP13760025.0
申请日：2013-09-06
申请人： Chrysalis Pharma AG
发明人： SPLEISS, Johannes
IPC分类号： A61K9/48 , A61K31/202 , A61K47/42
CPC分类号： A61K9/4825 , A61K9/4833 , A61K9/4866 , A61K9/4891 , A61K31/202 , A61K2300/00
摘要： Shelf life of soft gelatin capsules comprising a soft gelatin shell encapsulating a pharmaceutical formulation comprising cis-5,8,11,14,17-eicosapentaenoic acid (C20:5 n-3; "EPA") in free acid form in an amount from 25 wt % to 99 wt % of the formulation and cis-7,10,13,16,19-docosapentaenoic acid (C22:5 n-3; "DPA") in free acid form in an amount from 1 wt % to75 wt % of the formulation in which the gelatin component of the shell is Type B gelatin, is improved by replacing up to 75 wt % of the gelatin component with porcine Type A gelatin.
摘要翻译： 包含软胶囊的软明胶胶囊的保质期，所述胶囊包含药物制剂，其包含游离酸形式的顺式-5,8,11,14,17-二十碳五烯酸（C20：5n-3;“EPA”），其量为 25wt％至99wt％的制剂和游离酸形式的顺式-7,10,13,16,19-二十二碳五烯酸（C22：5n-3;“DPA”），其量为1wt％至75wt％ 通过用猪A型明胶替换至多75重量％的明胶组分来改进其中壳的明胶组分为B型明胶的配方的％。
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2.发明公开DPA-ENRICHED COMPOSITIONS OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN FREE ACID FORM 有权DPA富含不饱和多OMEGA-3脂肪酸的形式化合物中的自由
公开(公告)号：EP2800563A4
公开(公告)日：2015-06-17
申请号：EP13733671
申请日：2013-01-04
发明人： MAINES TIMOTHY J , MACHIELSE BERNARDUS N M , MEHTA BHARAT M , WISLER GERALD , DAVIDSON MICHAEL , WOOD PETER RALPH
CPC分类号： A61K31/202 , A61K9/4825 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： Methods for making DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form are presented.
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3.发明公开
公开(公告)号：EP3348262A1
公开(公告)日：2018-07-18
申请号：EP18158463.2
申请日：2013-01-04
发明人： MAINES, Timothy, J , MACHIELSE, Bernardus N M , MEHTA, Bharat M , WISLER, Gerald , DAVIDSON, Michael , WOOD, Peter Ralph
IPC分类号： A61K31/202 , A61K31/366 , A61K45/06 , A61P9/00
CPC分类号： A61K31/202 , A61K9/4825 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： Methods for making DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form are presented.
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4.发明公开DPA-ENRICHED COMPOSITIONS OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN FREE ACID FORM 有权DPA富含不饱和多OMEGA-3脂肪酸的形式化合物中的自由
公开(公告)号：EP2800563A1
公开(公告)日：2014-11-12
申请号：EP13733671.5
申请日：2013-01-04
发明人： MAINES, Timothy, J. , MACHIELSE, Bernardus N M , MEHTA, Bharat M. , WISLER, Gerald , DAVIDSON, Michael , WOOD, Peter Ralph
CPC分类号： A61K31/202 , A61K9/4825 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.
摘要翻译： DPA-富集的游离酸形式的多不饱和脂肪酸的药物组合物，治疗方法对于它们的用途，和流程用于精炼鱼油的组合物呈现。
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5.发明授权
公开(公告)号：EP1755565B2
公开(公告)日：2018-02-07
申请号：EP05702139.6
申请日：2005-02-07
申请人： Chrysalis Pharma AG
CPC分类号： A61K31/202 , A61K9/4825 , A61K9/4891 , A61K31/20 , A61K31/201 , A61K31/23
摘要： A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft to gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.
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公开(公告)号：EP2800563B1
公开(公告)日：2018-07-11
申请号：EP13733671.5
申请日：2013-01-04
发明人： MAINES, Timothy, J. , MACHIELSE, Bernardus N M , MEHTA, Bharat M. , WISLER, Gerald , DAVIDSON, Michael , WOOD, Peter Ralph
IPC分类号： A61K31/19 , A61K31/202 , A61K31/366 , A61K45/06 , A61K9/48 , A61P9/00
CPC分类号： A61K31/202 , A61K9/4825 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： Methods for making DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form are presented.
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