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公开(公告)号：EP3335043B1
公开(公告)日：2021-03-31
申请号：EP16836011.3
申请日：2016-08-12
发明人： MORAITIS, Andreas G.
IPC分类号： G01N33/50 , A61K31/575 , C07D217/08 , A61K31/4745 , A61K31/567 , A61K31/573 , G01N33/74
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公开(公告)号：EP3423453A1
公开(公告)日：2019-01-09
申请号：EP17760608.4
申请日：2017-02-28
发明人： HUNT, Hazel
IPC分类号： C07D471/04 , A61K31/569 , A61K39/395
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公开(公告)号：EP2429529B1
公开(公告)日：2015-01-14
申请号：EP10775401.2
申请日：2010-05-11
发明人： CLARK, Robin , FRY, Doug
IPC分类号： A61K31/535 , C07D471/04
CPC分类号： C07D471/04
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公开(公告)号：EP2429529A1
公开(公告)日：2012-03-21
申请号：EP10775401.2
申请日：2010-05-11
发明人： CLARK, Robin , FRY, Doug
IPC分类号： A61K31/535
CPC分类号： C07D471/04
摘要： The present invention provides amorphous solid forms of the compound of Formula I, as well as methods for preparing the compound of Formula I by precipitation.
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公开(公告)号：EP1761497B1
公开(公告)日：2008-09-03
申请号：EP05711316.9
申请日：2005-01-10
发明人： CLARK, Robin D. , RAY, Nicholas C. , BLANEY, Paul , HURLEY, Christopher , WILLIAMS, Karen , HUNT, Hazel , CLARK, David
IPC分类号： C07D217/04 , C07D217/06 , C07D217/08 , C07D401/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D513/06 , A61K31/4725 , A61K31/472 , A61P5/44
CPC分类号： C07D217/04 , C07D217/02 , C07D217/06 , C07D217/08 , C07D401/10 , C07D401/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/10 , C07D513/04 , C07D513/06
摘要： The present invention provides a novel class of azadecalin compounds of formula (I) and methods of using the compounds as glucocorticoid receptor modulators.
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公开(公告)号：EP1567167A4
公开(公告)日：2007-09-12
申请号：EP03768714
申请日：2003-11-05
发明人： BELANOFF JOSEPH K
CPC分类号： A61K31/59 , A61K31/00 , A61K31/56 , A61K31/573
摘要： This invention relates to the discovery that agents capable of inhibiting the biological action of the glucocorticoid receptor can be used in methods for treating gastroesophageal reflux disease in a subject.
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公开(公告)号：EP1778236A1
公开(公告)日：2007-05-02
申请号：EP05771551.8
申请日：2005-06-29
发明人： CLARK, Robin, D. , RAY, Nicholas C. , WILLIAMS, Karen , CRACKETT, Peter H. , HICKIN, Gwen , CLARK, David A.
IPC分类号： A61K31/506 , A61P25/24 , C07D419/04
CPC分类号： C07D239/545 , A61K31/506 , A61K31/513 , A61K31/551 , C07D401/04 , C07D403/04
摘要： The present invention provides a novel class of modified pyrimidine compounds and compositions and methods of using the compounds as glucocorticoid receptor modulators.
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8.发明公开ANTIGLUCOCORTICOID THERAPY FOR THE PREVENTION OF NEUROLOGICAL DAMAGE IN PREMATURE INFANTS 有权抗糖皮质激素治疗预防神经损伤对为时过早
公开(公告)号：EP1648439A2
公开(公告)日：2006-04-26
申请号：EP04757208.6
申请日：2004-07-22
发明人： BELANOFF, Joseph K.
IPC分类号： A61K31/235
CPC分类号： A61K31/56 , A61K31/567 , A61K31/569 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for preventing neurological damage associated with glucocorticoid therapy in ventilator-dependent low birth weight preterm infants. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.
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公开(公告)号：EP1581234A2
公开(公告)日：2005-10-05
申请号：EP03768706.8
申请日：2003-11-05
发明人： BELANOFF, Joseph, K.
IPC分类号： A61K31/56
CPC分类号： A61K31/59 , A61K31/00 , A61K31/56 , A61K31/573
摘要： This invention relates to the discovery that agents capable of inhibiting the biological action of the glucocorticoid receptor can be used in methods for treating migraine in a subject.
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10.发明公开
公开(公告)号：EP1534299A2
公开(公告)日：2005-06-01
申请号：EP03751785.1
申请日：2003-07-02
发明人： BELANOFF, Joseph, K.
IPC分类号： A61K31/56 , A61K31/565
CPC分类号： A61K31/7056 , A61K31/56 , A61K31/573 , A61K31/58 , A61K38/212 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the treatment of psychosis associated with interferon- therapy. The present invention further relates to kits for the treatment of Hepatitis C in a patient.
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