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    ANTIGLUCOCORTICOIDS FOR THE TREATMENT OF POSTPARTUM PSYCHOSIS
    1.
    发明公开
    ANTIGLUCOCORTICOIDS FOR THE TREATMENT OF POSTPARTUM PSYCHOSIS 审中-公开
    抗糖皮质激素治疗产后PSYCHOSE

    公开(公告)号：EP1599208A4

    公开(公告)日：2007-09-12

    申请号：EP04708184

    申请日：2004-02-04

    申请人： CORCEPT THERAPEUTICS INC

    发明人： BELANOFF JOSEPH K

    IPC分类号： A61K20060101 ,  A61K31/56 ,  A61K31/569 ,  A61P25/18

    CPC分类号： A61K31/56 ,  A61K31/569

    摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for treating postpartum psychosis. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for treating postpartum psychosis in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

    METHODS FOR INHIBITING COGNITIVE DETERIORATION IN ADULTS WITH DOWN'S SYNDROME
    4.
    发明公开
    METHODS FOR INHIBITING COGNITIVE DETERIORATION IN ADULTS WITH DOWN'S SYNDROME 有权
    VERFAHREN ZUR HEMMUNG DES KOGNITIVEN ABBAUS BEI ERWACHSENEN MIT DOWN-SYNDROM

    公开(公告)号：EP1432379A4

    公开(公告)日：2005-07-13

    申请号：EP02770441

    申请日：2002-08-27

    申请人： CORCEPT THERAPEUTICS INC

    发明人： BELANOFF JOSEPH K

    IPC分类号： A61J1/14 ,  A61K31/05 ,  A61K31/56 ,  A61K31/567 ,  A61K31/569 ,  A61K31/573 ,  A61K31/575 ,  A61K45/00 ,  A61P25/28 ,  A61K6/00

    CPC分类号： A61K31/573 ,  A61K31/56 ,  A61K31/567 ,  A61K31/575

    摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptors can be used in methods for preventing or reversing cognitive deterioration in adults with Down's syndrome. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for preventing or reversing cognitive deterioration in a DS patient including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

    摘要翻译： 本发明一般涉及精神病学领域。 特别地，本发明涉及以下发现：能够抑制皮质醇与其受体结合的药剂可用于预防或逆转唐氏综合症患者的认知恶化的方法。 米非司酮，一种有效的特异性糖皮质激素受体拮抗剂，可用于这些方法。 本发明还提供了用于预防或逆转DS患者的认知恶化的试剂盒，其包括糖皮质激素受体拮抗剂和教导糖皮质激素受体拮抗剂施用的适应症，剂量和时间表的教学材料。