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62 条记录 (耗时 0.015 秒)

    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
    7.
    发明公开
    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES 审中-公开

    公开(公告)号：EP3221347A1

    公开(公告)日：2017-09-27

    申请号：EP15797940.2

    申请日：2015-11-16

    申请人： GE Healthcare BioProcess R&D AB

    发明人： RODRIGO, Gustav ,  BJORKMAN, Tomas ,  ANDER, Mats

    IPC分类号： C07K16/06 ,  C07K1/22

    摘要： An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:22, SEQ ID NO 51 or SEQ ID NO 52 wherein at least the asparagine or serine residue at the position corresponding to position 11 in SEQ ID NO:4-7 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.

    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
    8.
    发明公开
    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES 审中-公开
    突变的免疫球蛋白结合多肽

    公开(公告)号：EP3221338A1

    公开(公告)日：2017-09-27

    申请号：EP15797942.8

    申请日：2015-11-16

    申请人： GE Healthcare BioProcess R&D AB

    发明人： RODRIGO, Gustav ,  BJORKMAN, Tomas ,  ANDER, Mats

    IPC分类号： C07K14/31 ,  B01D15/38 ,  C12N15/09

    摘要： An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO 26 or SEQ ID NO 27, wherein at least the alanine residue at the position corresponding to position 42 in SEQ ID NO:4-7 has been mutated to arginine and/or wherein at least the aspartic acid residue at the position corresponding to position 37 in SEQ ID NO:4-7 has been mutated to glutamic acid.

    摘要翻译： 如SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：2所示的包含葡萄球菌蛋白A的Fc结合结构域的突变体（SpA）的改善的碱稳定性的Fc结合多肽 SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：26或SEQ ID NO：27，其中至少对应于位置42的位置的丙氨酸残基 在SEQ ID NO：4-7中突变为精氨酸和/或其中在对应于SEQ ID NO：4-7中的37位的位置处至少天冬氨酸残基已经突变为谷氨酸。

    CHROMATOGRAPHY METHOD
    9.
    发明公开
    CHROMATOGRAPHY METHOD 审中-公开
    色谱法

    公开(公告)号：EP3160982A1

    公开(公告)日：2017-05-03

    申请号：EP15729376.2

    申请日：2015-06-04

    申请人： GE Healthcare BioProcess R&D AB

    发明人： MALOISEL, Jean-Luc ,  LIND, Ola ,  NOREN, Bjorn ,  PALMGREN, Ronnie

    IPC分类号： C07K1/22 ,  C07K16/00 ,  C07K1/14

    摘要： The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mAbs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mAbs or parts thereof.

    摘要翻译： 本发明涉及一种通过使用具有薄外层和核官能化的特别设计的色谱珠来在色谱过程中去除诸如病毒的大污染物以纯化靶分子，优选单克隆抗体，mAb的方法 与配体吸附mAb或其部分。