利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.02 秒)

    Novel protein complexes
    1.
    发明公开
    Novel protein complexes 失效
    新蛋白复合物

    公开(公告)号：EP0914777A1

    公开(公告)日：1999-05-12

    申请号：EP98108709.1

    申请日：1998-05-13

    申请人： Kyowa Hakko Co., Ltd.

    发明人： Ogasawara, Masashi ,  Yamamoto, Kazuhiro ,  Watanabe, Makoto

    IPC分类号： A23J3/00 ,  A23J3/06 ,  A23J3/18

    CPC分类号： A21D13/064 ,  A21D2/26 ,  A23C11/04 ,  A23J3/06 ,  A23J3/08 ,  A23J3/10 ,  A23J3/12 ,  A23J3/16 ,  A23J3/18 ,  A23L27/60 ,  A23L29/10

    摘要： A complex of a protein with a saponin or bile acid, an emulsifier comprising the complex, an emulsified composition comprising the complex, a process for preparing an emulsified composition which comprises mixing the complex, a dough improver comprising the complex, a dough comprising the complex, bread prepared by baking up the dough, and a process for preparing bread, which comprises baking up the dough.

    摘要翻译： 蛋白质与皂苷或胆汁酸的复合物，包含所述络合物的乳化剂，包含所述络合物的乳化组合物，制备乳化组合物的方法，其包括将所述络合物，包含所述络合物的面团改良剂， 通过烘焙面团制备的面包，以及制备面包的方法，其包括烘烤面团。

    PROCESS FOR PREPARING CHOLESTEROL-LOWERING COMPOUND
    2.
    发明公开
    PROCESS FOR PREPARING CHOLESTEROL-LOWERING COMPOUND 失效
    维他命Zur Herstellung einer Substanz mit Cholesterol-vermindernden Eigenschaften

    公开(公告)号：EP0879892A1

    公开(公告)日：1998-11-25

    申请号：EP97911489.9

    申请日：1997-11-07

    申请人： Kyowa Hakko Co., Ltd.

    发明人： SAITOH, Chiaki ,  KUMAZAWA, Hideyo ,  AISAKA, Kazuo ,  MIZUKAMI, Toru ,  KATSUMATA, Ryoichi ,  ANDO, Katsuhiko ,  OCHIAI, Keiko ,  OUCHI, Kozo

    IPC分类号： C12P33/00 ,  C12N9/04 ,  C12N1/20 ,  A23L1/29

    CPC分类号： C12Y101/99001 ,  A23K20/189 ,  A23L5/25 ,  A23L13/48 ,  A23L15/25 ,  A23L17/65 ,  C12N9/0006 ,  C12P33/00

    摘要： A process for preparing a practical cholesterol-lowering compound by converting the cholesterol contained in a food or feed to coprostanol having very low intestinal absorption by utilizing an enzymatic action. The content of cholesterol in cholesterol-containing materials such as meat, eggs, milk, fishery products, and cooked and processed foods containing these products, or feed for animals, poultry, fish culture and the like is lowered by treating these materials with three enzymes, i.e., a cholesterol dehydrogenase having an optimal pH value in a neutral pH range and a 4-cholesten-3-one dehydrogenase and a coprostan-3-one dehydrogenase both having an optimal pH value in a weakly acidic range, or cells containing these enzymes to convert cholesterol to coprostanol.

    摘要翻译： 通过利用酶作用将食物或饲料中所含的胆固醇转化成具有非常低的肠吸收的coprostanol来制备实用的降胆固醇化合物的方法。 通过用三种酶处理这些物质，降低含有含胆固醇的材料如肉，蛋，牛奶，渔业产品和含有这些产品的熟化和加工食品中的胆固醇或动物，家禽，鱼类培养物等的含量 ，即在中性pH范围内具有最佳pH值的胆固醇脱氢酶和在弱酸性范围内具有最佳pH值的4-胆甾烯-3-酮脱氢酶和副雄甾-3-酮脱氢酶，或含有这些的细胞 将胆固醇转化为coprostanol的酶。

    IMIDAZOQUINAZOLINE DERIVATIVES
    3.
    发明公开
    IMIDAZOQUINAZOLINE DERIVATIVES 失效
    咪唑喹唑啉衍生物

    公开(公告)号：EP0863144A1

    公开(公告)日：1998-09-09

    申请号：EP97937841.1

    申请日：1997-08-29

    申请人： Kyowa Hakko Co., Ltd.

    发明人： ONODA, Yasuo ,  NOMOTO, Yuji ,  OHNO, Tetsuji ,  YAMADA, Koji ,  ICHIMURA, Michio

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention provides imidazoquinazoline derivatives represented by formula (I):
    wherein R 1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted bicycloalkyl, substituted or unsubstituted tricycloalkyl or the like, R 2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted bicycloalkyl, substituted or unsubstituted tricycloalkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted aralkyl or the like, R 3 represents hydrogen, substituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted bicycloalkyl, substituted or unsubstituted tricycloalkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted aralkyl or the like, and R 2 and R 3 are combined to represent a substituted or unsubstituted N-containing heterocyclic group, X represents O or S, or pharmaceutically acceptable salts thereof, which have potent and selective cyclic guanosine 3',5'-monophosphate (cGMP)-specific phosphodiesterase (PDE) inhibitory activity and are useful for treating or ameliorating cardiovascular diseases such as thrombosis, angina pectoris, hypertension, heart failure, arterial sclerosis, as well as asthma, impotence and the like.

    摘要翻译： 本发明提供了由式（I）表示的咪唑并喹唑啉衍生物：其中R1代表氢，取代或未取代的低级烷基，取代或未取代的环烷基，取代或未取代的双环烷基，取代或未取代的三环烷基等，R2代表氢，取代或未取代的低级 烷基，被取代或未被取代的环烷基，被取代或未被取代的双环烷基，被取代或未被取代的三环烷基，被取代或未被取代的低级链烯基，被取代或未被取代的芳烷基等，R3代表氢， 或未经取代的三环烷基，经取代或未经取代的低级链烯基，经取代或未经取代的芳烷基等，且R 2及R 3结合表示经取代或未经取代的含N杂环基，X表示O或S或药学 它们具有有效和选择性的环鸟苷3'，5'-单磷酸（cGMP）特异性磷酸二酯酶（PDE）抑制活性，并且可用于治疗或改善心血管疾病，例如血栓形成，心绞痛，高血压，心力衰竭 ，动脉硬化，以及哮喘，阳痿等。