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公开(公告)号：EP2370136A4
公开(公告)日：2015-12-30
申请号：EP09830989
申请日：2009-12-01
发明人： ARMER THOMAS A , COOK ROBERT O , ALFREDSON TERRY , SUN ANTHONY
IPC分类号： A61K45/06 , A61K9/00 , A61K9/08 , A61K31/4174 , A61K47/02 , A61K47/26 , A61M11/00 , A61M15/00 , A61M21/02 , A61P25/20
CPC分类号： A61M11/00 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/08 , A61K31/4174 , A61K45/06 , A61K47/02 , A61K47/26 , A61M11/005 , A61M15/00 , A61M21/02 , A61M2209/06 , A61K2300/00
摘要： Methods, devices and kits for treating sleep disorders, anxiety disorders, and developmental disorders, and/or for inducing an arousable state of sedation in a subject, are described. For example, inhalation methods, devices and kits for treating insomnia, anxiety and/or ADHD using one or more α2-adrenergic agonists such as dexmedetomidine or clonidine are described.
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公开(公告)号：EP2794577A4
公开(公告)日：2015-05-20
申请号：EP12861018
申请日：2012-12-20
发明人： WU LIBO , WATANABE WIWIK
CPC分类号： A61K9/12 , A61K9/008 , A61K31/5513 , A61K31/5517
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公开(公告)号：EP2793580A4
公开(公告)日：2015-05-20
申请号：EP12860451
申请日：2012-06-22
发明人： ZHANG JIAN , COOK ROBERT O
CPC分类号： C07D457/12 , C07D519/00 , C07D519/02
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公开(公告)号：EP2794577A1
公开(公告)日：2014-10-29
申请号：EP12861018.5
申请日：2012-12-20
发明人： WU, Libo , WATANABE, Wiwik
IPC分类号： C07D243/12 , A61K9/12 , A61P25/08 , A61P25/20 , A61P25/22
CPC分类号： A61K9/12 , A61K9/008 , A61K31/5513 , A61K31/5517
摘要： Methods and compositions for producing formulations for orally inhaled benzodiazepines that do not require the presence of a surface modifier are described. The formulations are useful in the treatment of epileptic seizures.
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公开(公告)号：EP2310074A4
公开(公告)日：2014-07-23
申请号：EP09794831
申请日：2009-07-10
发明人： COOK ROBERT O
CPC分类号： A61M15/009
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公开(公告)号：EP2723735A1
公开(公告)日：2014-04-30
申请号：EP12803230.7
申请日：2012-06-22
发明人： COOK, Robert, O. , ZHANG, Jian , ARMER, Thomas, A.
IPC分类号： C07D457/00
CPC分类号： C07D519/02 , A61K9/0075 , A61K9/0078 , A61K31/495 , A61K31/4985 , C07D457/04 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HTiD and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and composittons disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
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7.发明公开METHOD OF ADMINISTERING DOSE-SPARING AMOUNTS OF FORMOTEROL FUMARATE-BUDESONIDE COMBINATION PARTICLES BY INHALATION 审中-公开方法富马酸福莫特罗，布地奈德组合粒子通过吸入给药量节能量
公开(公告)号：EP2429297A4
公开(公告)日：2013-12-25
申请号：EP10780911
申请日：2010-05-14
IPC分类号： A61K9/72 , A61K31/167 , A61K31/58
CPC分类号： A61K9/0075 , A61K9/008 , A61K31/167 , A61K31/58 , A61K2300/00
摘要： Disclosed are methods, and related compositions, that include administering a dose- sparing amount of a formulation that includes inhalation particles to a subject by inhalation; wherein the inhalation particles comprise formoterol fumarate and budesonide, the formoterol fumarate and budesonide being in a distributed encapsulated morphology with respect to one another within said inhalation particles and the formoterol fumarate being in a predetermined mass ratio with regard to the budesonide within said inhalation particles.
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8.发明公开MULTIPLE ACTIVE PHARMACEUTICAL INGREDIENTS COMBINED IN DISCRETE INHALATION PARTICLES AND FORMULATIONS THEREOF 审中-公开几种药物活性成分组合用于离散粒子吸入及其制剂
公开(公告)号：EP1906919A4
公开(公告)日：2012-12-26
申请号：EP06787817
申请日：2006-07-17
发明人： MOHSEN NAHED M , ARMER THOMAS A , COOK ROBERT O
IPC分类号： A61K9/00 , A61K9/14 , A61K31/167 , A61K31/56 , A61K31/58
CPC分类号： A61K9/0073 , A61K31/167 , A61K31/58 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2310074A1
公开(公告)日：2011-04-20
申请号：EP09794831.9
申请日：2009-07-10
发明人： COOK, Robert, O.
IPC分类号： A61M11/00
CPC分类号： A61M15/009
摘要： A metered does inhaler which includes a canister assembly which has a minimal volume canister and primeless valve to reduce waste, minimize total drug contained therein, and increase the reproducibility of dosage delivered.
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公开(公告)号：EP2515978B1
公开(公告)日：2018-02-14
申请号：EP10840198.5
申请日：2010-12-23
CPC分类号： A61M15/0091 , A61M15/0021 , A61M15/0026 , A61M15/009 , A61M15/0096 , A61M2206/16 , A61M2206/20 , B01F5/0428 , F04F5/463 , F15D1/02
摘要： The present invention provides for an enhanced eductor element that significantly increases the amount of pressure generated at the siphon tube without significantly increasing the flow resistance through the eductor. The invention further provides for breath-actuated inhalation devices comprising the enhanced eductor element as an actuation mechanism.
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