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    MULTI-ANGLE DYNAMIC LIGHT SCATTERING
    5.
    发明公开
    MULTI-ANGLE DYNAMIC LIGHT SCATTERING 审中-公开

    公开(公告)号：EP3521806A1

    公开(公告)日：2019-08-07

    申请号：EP18155428.8

    申请日：2018-02-06

    申请人： Malvern Panalytical Limited

    发明人： Hamilton, Douglas ,  Corbett, Jason

    IPC分类号： G01N15/02

    摘要： A method of determining particle size distribution from multi-angle dynamic light scattering data, comprising: obtaining a series of measured correlation functions g ( θ i ) at scattering angles θ i ; and solving an equation comprising g θ 1 … g θ n = α 1 K θ 1 … α n K θ n x , wherein: K ( θ i ) is the instrument scattering matrix computed for angle i , x is the particle size distribution, and α i is the scaling coefficient for angle i. The method comprises using the steps: a) providing initial estimates for scaling factors α 2 to α n , and defining α 1 = 1; b) iterating scaling factors α 2 to α n using a non-linear solver; c) solving for x using a linear solver; d) calculate residual; e) repeat steps a) to d) while the residual is greater than a predefined exit tolerance.

    PARTICLE BOUNDARY IDENTIFICATION
    7.
    发明公开
    PARTICLE BOUNDARY IDENTIFICATION 审中-公开
    粒子边界识别

    公开(公告)号：EP3293672A1

    公开(公告)日：2018-03-14

    申请号：EP16187702.2

    申请日：2016-09-07

    申请人： Malvern Panalytical Limited

    发明人： JONES, Chris

    IPC分类号： G06K9/46 ,  G06K9/62

    CPC分类号： G06K9/4604 ,  G06K9/4642 ,  G06K9/6288

    摘要： A method of characterising particles (140) by using a processor (301) to identify a particle boundary (165) of at least one particle (140) in an image (135, 171). The method comprises processing the image (135, 171) using an intensity based method to determine a first boundary (160a) corresponding with the at least one particle (140) and processing the image (135, 171) using a gradient based method to determine a second boundary (160b) corresponding with at the least one particle (140). The the first boundary (160a) and second boundary (160b) are combined to create a combined boundary (160). A particle boundary (165) of the at least one particle (140) is determined using the combined boundary.

    摘要翻译： 一种通过使用处理器（301）来识别图像（135,171）中的至少一个粒子（140）的粒子边界（165）来表征粒子（140）的方法。 该方法包括使用基于强度的方法处理图像（135,171）以确定与至少一个粒子（140）相对应的第一边界（160a）并且使用基于梯度的方法处理图像（135,171）以确定 与至少一个颗粒（140）对应的第二边界（160b）。 第一边界（160a）和第二边界（160b）被组合以产生组合的边界（160）。 使用组合的边界来确定至少一个粒子（140）的粒子边界（165）。

    APPARATUS FOR CHARACTERISING PARTICLES
    9.
    发明公开
    APPARATUS FOR CHARACTERISING PARTICLES 审中-公开

    公开(公告)号：EP4365571A1

    公开(公告)日：2024-05-08

    申请号：EP22205103.9

    申请日：2022-11-02

    申请人： Malvern Panalytical Limited

    发明人： Latunde-Dada, Seyi

    IPC分类号： G01N15/06 ,  G01N15/14

    CPC分类号： G01N15/06 ,  G01N2015/003820130101 ,  G01N15/1429 ,  G01N2015/148620130101 ,  G01N15/1433 ,  G01N15/075

    摘要： An apparatus (100) is provided for characterising particles using nanoparticle tracking analysis. The apparatus comprises: a cell (101) for containing a sample comprising a plurality of particles suspended in a fluid; a light source (102) configured to illuminate the sample; an imaging system (103) configured to collect light (112) scattered or fluoresced by particles moving within the cell (101) and within a detection region (111) of the imaging system (103) and capture a video of the particles moving within the detection region (111); and a computer (104). The computer is configured to process the video to automatically determine a depth of the detection region (111). Determining the depth of the detection region (111) comprises: tracking the particles moving within the detection region (111), thereby producing a track for each of the particles; and analysing how a measured property of the tracks within a subsection of the video changes as the size of the subsection is varied.