公开(公告)号：EP0120927A4

公开(公告)日：1986-07-08

申请号：EP83903331

申请日：1983-09-23

申请人： NEW ENGLAND NUCLEAR CORP

发明人： LEE DENNY L Y ,  HAY ROBERT DUNCAN

IPC分类号： G01R33/48 ,  A61B5/055 ,  G01R33/383 ,  G01R33/387 ,  H01F7/02 ,  G01R33/08

CPC分类号： G01R33/383 ,  Y10S505/844

摘要： An NMR imaging apparatus (10) having a desired imaging volume for imaging of biological tissue, said apparatus comprising bias means (20) for generating a bias field, means for generating gradient fields, and radio frequency means for applying a pulse of electromagnetic radiation to the biological tissue and for detecting the resultant signals emitted from said tissue; wherein said bias means comprises a plurality of dipole ring magnets, (20) each dipole ring magnet comprising a plurality of segments, (22) each segment comprising an oriented, anisotropic permanent magnet material (23) arranged in a ring so that there is a substantially continuous ring of permanent magnet material; wherein the inner radius of at least one dipole ring magnet is different from the inner radius of an adjacent dipole ring magnet.

公开(公告)号：EP0099405A4

公开(公告)日：1984-09-28

申请号：EP83900822

申请日：1983-01-21

申请人： NEW ENGLAND NUCLEAR CORP

发明人： TWEEDLE MICHAEL F

IPC分类号： A61K51/00 ,  A61K51/04 ,  C07F9/70 ,  C07F13/00 ,  C07F9/66 ,  A61K43/00 ,  A61K49/00 ,  C07F9/02

CPC分类号： A61K51/0497 ,  A61K2123/00 ,  C07F9/703 ,  C07F13/005

公开(公告)号：EP0090861A4

公开(公告)日：1984-02-13

申请号：EP83900093

申请日：1982-10-15

申请人： NEW ENGLAND NUCLEAR CORP

发明人： SUBRAMANYAM VINAYAKAM ,  LINDER KAREN E

IPC分类号： A61K51/04 ,  C07F9/54 ,  C07F13/00 ,  C07F9/28 ,  A61K43/00 ,  A61K49/00 ,  C07F9/66 ,  G01T1/00

CPC分类号： C07F9/5449 ,  A61K51/04 ,  A61K2123/00 ,  C07F13/005

摘要： A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex. The compound has a formula selected from: wherein: R, R', R'', R''', R1, R2, R3, R4, R5. R6. R21, R22 and R23 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic group; and R plus Ri in formula (A) may be taken together to form a cyclic compound; A, A', A'', A1, A2, A3, A4, A5 and A6 are independently selected donor atoms, each having a free electron pair available for accepting a proton to provide a charged ligand and having the capability of complexing with Tc-99m to form a cationic complex; B is an atom selected from the group of donor atoms having a pair of electrons for complexing with Tc-99m or Tc-99, boron or from the elements listed in Group IV A of the periodic table; Y1, Y2, Y3, Y4, Y5 and Y6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic groups; X and X' are saturated or unsaturated alkyl groups; Z is an anion; i is an integer from 1 to 6; j, j' and j'' are each independently 0 or 1; k1, k2, k3, 4, k5 and k6 are each independently 0 or 1; n, n' and n'' are each independently the integer 1 to 2; n1, n2, n3, n4, n5, n6, are independently 0 or 1; n7 and n8 are each an integer from 1 to 6; n9, n10, n11 and n12 are each an integer from 1 to 3; m is 0 or 1; r', r'' and r''' are independently 0 or 1; and t and t' are independently 0 or 1.