公开(公告)号：EP4512815A2

公开(公告)日：2025-02-26

申请号：EP24209420.9

申请日：2020-09-03

Applicant: GE Healthcare AS

Inventor： BALES, Brian, C. ,  RISHEL, Michael James ,  DINN, Sean

IPC: C07F13/00

Abstract: The invention relates to isomers of chelate compounds and their use as contrast agents in magnetic resonance imaging (MRI) procedures.

公开(公告)号：EP4466276A1

公开(公告)日：2024-11-27

申请号：EP23703510.0

申请日：2023-01-13

Applicant: Elkem Silicones France SAS ,  Centre National de la Recherche Scientifique ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  CPE Lyon

Inventor： MIRGALET, Raphaël ,  VIVIEN, Anthony ,  CAMP, Clément ,  VEYRE, Laurent ,  THIEULEUX, Chloé

IPC: C07F7/18 ,  C07F13/00 ,  C08K5/00

公开(公告)号：EP4377308B1

公开(公告)日：2024-11-20

申请号：EP22782448.9

申请日：2022-09-09

Inventor： POLASEK, Miloslav ,  DAVID, Tomas ,  STRAKA, Michal ,  JAROS, Adam

IPC: G01N33/68 ,  C07D401/14 ,  C07F3/08 ,  C07F3/06 ,  C07F3/04 ,  C07K7/06 ,  C07F9/6524 ,  C07D471/22 ,  A61K49/12 ,  A61K49/08 ,  A61K51/04 ,  C07F5/00 ,  C07F13/00 ,  C07F15/00 ,  A61K49/14 ,  C07F7/24 ,  A61K51/08

公开(公告)号：EP3160514B1

公开(公告)日：2024-07-31

申请号：EP15812491.7

申请日：2015-06-22

IPC: A61K51/04 ,  A61K103/00 ,  C07B59/00 ,  C07F13/00

CPC classification number: A61K51/0478 ,  A61K51/0487 ,  A61K51/0497 ,  C07F13/00 ,  C07F13/005 ,  A61K51/0402 ,  C07B59/004

公开(公告)号：EP3705484B1

公开(公告)日：2024-05-15

申请号：EP17930553.7

申请日：2017-11-01

IPC: C07F13/00 ,  B01J31/22 ,  C01B13/02 ,  C25B5/00 ,  C25B1/04

CPC classification number: B01J31/22 ,  C01B13/02 ,  C25B1/04 ,  C25B5/00 ,  Y02E60/36 ,  C07F13/005

公开(公告)号：EP3334464B1

公开(公告)日：2024-04-10

申请号：EP16835998.2

申请日：2016-08-12

Inventor： GALE, Eric M. ,  CARAVAN, Peter

IPC: A61K49/06 ,  C07F13/00 ,  C07D213/80 ,  C07D213/87 ,  C07D217/14 ,  C07D233/58 ,  C07D235/14 ,  C07D213/40 ,  C07D213/65 ,  C07D213/68 ,  C07K7/06 ,  C07K7/08 ,  A61K49/08 ,  A61K49/14 ,  A61K49/10

公开(公告)号：EP4093742A1

公开(公告)日：2022-11-30

申请号：EP21733066.1

申请日：2021-06-02

Applicant: Biochem Zusatzstoffe Handels- und Produktionsgesellschaft mbH

Inventor： BICE, Ismet ,  GREIMANN, Heiko

IPC: C07F1/00 ,  C07F3/00 ,  C07F13/00 ,  C07F15/02 ,  A23K20/105 ,  A23K20/20 ,  A61K33/00

公开(公告)号：EP4025259A1

公开(公告)日：2022-07-13

申请号：EP20767545.5

申请日：2020-09-03

Applicant: GE Healthcare AS

Inventor： BALES, Brian, C ,  RISHEL, Michael, James ,  DINN, Sean, R

IPC: A61K49/10 ,  C07D471/08 ,  C07F13/00

公开(公告)号：EP3738967A1

公开(公告)日：2020-11-18

申请号：EP20168046.9

申请日：2016-08-11

Applicant: Galera Labs, LLC

Inventor： KEENE, Jeffery L. ,  SCHALL, Otto F. ,  RILEY, Dennis P.

IPC: C07F13/00 ,  C07F15/02 ,  C07F15/04 ,  C07F1/08 ,  A61K9/00 ,  A61K47/14 ,  A61P1/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00

Abstract: Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula -OC(O)X1. (Formula A) each of the two axial ligands has the formula -OC(=O)X1 wherein each X1 is independently substituted or unsubstituted phenyl or -C(-X2)(-X3)(-X4); each X2 is independently substituted or unsubstituted phenyl, or substituted or unsubstituted alkyl; each X3 is independently hydrogen, hydroxyl, alkyl, amino, -X5C(=O)R13 where X5 is NH or O, and R13 is C1-C18 alkyl, substituted or unsubstituted aryl or C1-C18 aralkyl, or -OR14, where R14 is C1-C18 alkyl, substituted or unsubstituted aryl or C1-C18 aralkyl, or together with X4 is (=O); and each X4 is independently hydrogen or together with X3 is (=O).

公开(公告)号：EP3649140A1

公开(公告)日：2020-05-13

申请号：EP18733554.2

申请日：2018-06-18

Applicant: Ruhr-Universität Bochum

Inventor： METZLER-NOLTE, Nils ,  SIEGMUND, Daniel ,  BANDOW, Julia ,  SCHÄKERMANN, Sina

IPC: C07F13/00 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/04