公开(公告)号：EP0966330A1

公开(公告)日：1999-12-29

申请号：EP98921394.0

申请日：1998-03-10

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： ZINGER, Freddy

IPC分类号： A61B17 ,  A61M5 ,  B05B7 ,  B05B11 ,  B05C5 ,  B05C17

CPC分类号： B05C17/0133 ,  A61B17/00491 ,  A61M5/31575 ,  A61M5/31581 ,  A61M2005/3152 ,  A61M2039/224 ,  A61M2039/226 ,  B05B7/2467 ,  B05B11/02 ,  B05C17/00553 ,  B05C17/013

摘要： The invention relates to an applicator (10) for applying a single- or multicomponent fluid, especially a tissue glue, comprising a casing (12) to which at least one reservoir (16) for the fluid can be attached. Said reservoir (16) has an outlet (28) and a piston (20) which is positioned in such a way that it can slide towards said outlet (28). A cocking lever (58) is pivotably mounted on the casing (12). When manually operated, said cocking lever moves a trigger element (54) by which means a spring (46) is stretched to store mechanical energy. The trigger element (54) is coupled with a driving element (66), which when driven by the stored mechanical energy of the spring (46) over an incremental distance moves a pressing element (84), said pressing element acting upon the piston (20) to push it towards the outlet (28) of the reservoir (16).

公开(公告)号：EP0691858B1

公开(公告)日：1999-12-15

申请号：EP94913061.1

申请日：1994-03-27

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： MARTINOWITZ, Uri ,  BAL, Frederic

IPC分类号： A61L25/00 ,  C12N5/00

CPC分类号： A61L27/225

摘要： A fibrin glue comprising a component A which comprises a cryoprecipitate of whole blood and a sufficient amount of tranexamic acid 4-(aminomethyl)cyclohexane carboxylic acid or its pharmaceutically acceptable salts and, a component B comprising a proteolytic enzyme being capable of cleaving specifically fibrinogen present in component A and causing the formation of a fibrine polymer.

公开(公告)号：EP0925026A1

公开(公告)日：1999-06-30

申请号：EP96931070.0

申请日：1996-09-10

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： ZINGER, Freddy

IPC分类号： A61B17 ,  A61L24 ,  A61M5 ,  A61B19

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61B2090/037

摘要： The applicator device comprises a plurality of supply containers (112), each of which is mechanically connected via fluid control device (148) to a common connecting headpiece (160). Each fluid control device (148) is provided with a first port (152) connected to said common connecting headpiece (160). A second port (150) of each fluid control device (148) is connected to a syringe body (114). Further, each fluid control device (148) comprises a third port adapted to have a medicinal vessel connected therethrough. Said third port is provided with an adaptor (154) for receiving said medicinal vessel and is further provided with a fluid conduit member which, when the vessel is received in the adaptor (154), extends into the interior of the vessel. Each flow control member is selectively movable from a first flow control position enabling a flow path between a first pair of two ports of the fluid control device and a second flow control position enabling a flow path between a second pair of two ports of the fluid control device, each flow control member being coupled to one of those ports for manipulation between said flow control positions.

公开(公告)号：EP0651659B1

公开(公告)日：1997-04-09

申请号：EP93915861.4

申请日：1993-07-09

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： BARNEA, Efrach

IPC分类号： A61L25/00 ,  A61K35/54

摘要： A two component fibrin-glue composition comprising the components A and B, wherein component A comprises fibrinogen and a protease inhibitor, component B comprises a proteolytic enzyme being capable of cleaving specifically fibrinogen and causing formation of the fibrin polymer and additionally ingredients for culturing embryonic cells of mammals in one or both of the components A and B.

公开(公告)号：EP0534178B1

公开(公告)日：2001-04-18

申请号：EP92114942.3

申请日：1992-09-02

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： Martinowitz, Uri, Dr. ,  Bal, Frederic

IPC分类号： A61L24/10

CPC分类号： A61L24/106 ,  A61L2/0088 ,  A61L24/0005

公开(公告)号：EP0968008A1

公开(公告)日：2000-01-05

申请号：EP98904163.7

申请日：1998-01-30

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： NUR, Israel ,  BAR, Lilliana ,  LIEBERMAN, Oded

IPC分类号： A61L25/00 ,  A61K38/36 ,  C07K14/75

CPC分类号： C07K14/75 ,  A61K38/363 ,  A61L24/106

摘要： A stabilized solution of fibrinogen containing samples, in particular a stabilized solution of the biological active component (BAC) which is a solution of proteins derived from blood plasma comprising fibrinogen, tranexamic acid and arginine or lysine or mixtures of arginine and lysine, their pharmaceutically acceptable salts, as well as, optionally, substances forming a buffered solution in aqueous medium.

公开(公告)号：EP0925027A1

公开(公告)日：1999-06-30

申请号：EP97909236.0

申请日：1997-09-09

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： ZINGER, Freddy

IPC分类号： A61B17 ,  A61M5

CPC分类号： A61B17/00491 ,  A61B2017/00495

摘要： A multicomponent tissue adhesive device (10) provided with several reservoirs (14) respectively for a liquid component, each reservoir (14) presenting a front end (16,20) with an opening (18) enabling the liquid concerned to be dispensed. The front ends (16,20) of the reservoirs (14) are located in accommodating connecting pieces (42) of a connecting head piece (38).The connecting pieces (42) are provided with radially outward extending projecting parts (92). The reservoirs (14) are held by means of a holding device (52). The application device (10) is also provided with a coupling element (74) for releaseably connecting the holding device to the connecting head piece (38), wherein the coupling element (74) presents an encompassing part (76) with several encompassing areas (82) for at least partial encompassing of the accomodating connecting pieces (42) and mounting on the sides opposite the holding device (52) of the projecting parts (92) of the accomodating connecting pieces (42).

公开(公告)号：EP1845860B1

公开(公告)日：2009-03-11

申请号：EP05811155.0

申请日：2005-11-22

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： GOLDBERG, Edit

IPC分类号： A61B17/00

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00526 ,  A61M5/19

摘要： Disclosed is an applicator device ( 10) for applying a multi-component fluid, especially a multi-component tissue glue, comprising a plurality of substantially cylindrical supply containers (12) for respectively one component of the fluid to be applied, each supply container ( 12) having a front end (16) with an out¬ let opening (18), a rear end (22) opposite to the front end ( 16), and a slidably displaceable piston (24) arranged within the supply container ( 12) and having a piston rod (26) extending out of the rear end (22) for operating the piston (24). Moreover, the applicator device includes a manifold (72) having terminal ends (50,58) with a first port for fluid connection with the front ends (16) of the supply containers (12), the manifold (72) further having internal channels (62) extending from the first ports of the terminal ends (50,58) to an outlet site. Finally, also a holding element (38) for holding the supply containers ( 12), and a coupling clement (74) extending from the holding element (38) and having a connection end (76) connected to the manifold (72) arc pro¬ vided, wherein the connection end (76) of the coupling element (74) is bonded to the manifold (72).

公开(公告)号：EP0925026B1

公开(公告)日：2003-02-05

申请号：EP96931070.5

申请日：1996-09-10

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： ZINGER, Freddy

IPC分类号： A61B17/00 ,  A61M5/19

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61B2090/037

摘要： The applicator device comprises a plurality of supply containers (112), each of which is mechanically connected via fluid control device (148) to a common connecting headpiece (160). Each fluid control device (148) is provided with a first port (152) connected to said common connecting headpiece (160). A second port (150) of each fluid control device (148) is connected to a syringe body (114). Further, each fluid control device (148) comprises a third port adapted to have a medicinal vessel connected therethrough. Said third port is provided with an adaptor (154) for receiving said medicinal vessel and is further provided with a fluid conduit member which, when the vessel is received in the adaptor (154), extends into the interior of the vessel. Each flow control member is selectively movable from a first flow control position enabling a flow path between a first pair of two ports of the fluid control device and a second flow control position enabling a flow path between a second pair of two ports of the fluid control device, each flow control member being coupled to one of those ports for manipulation between said flow control positions.

公开(公告)号：EP0800361B1

公开(公告)日：1999-05-19

申请号：EP95943204.8

申请日：1995-12-23

申请人： OMRIX BIOPHARMACEUTICALS S.A.

发明人： ZINGER, Freddy

IPC分类号： A61B17/00 ,  A61M35/00 ,  A61B1/00 ,  A61M25/01

CPC分类号： A61M25/01 ,  A61B1/0055 ,  A61B17/00491 ,  A61B2017/00495 ,  A61C5/64 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

摘要： The device for applying one or several fluids, particularly a multi-component fluid, such as medical tissue or dental adhesives, comprises a head piece (9) having channels (25 to 28) for each fluid extending from an inlet side of the head piece (9) to a connection site of the head piece (9). The tubular body (10) comprises an inlet end facing the connection site of the head piece (9) and an outlet end facing away from the inlet end. The tubular body (10) comprises an outer wall, which, at least sectionally, is configured such that the tubular body (10) is plastically deformable, particularly plastically bendable.