公开(公告)号：EP0486070B1

公开(公告)日：1994-11-09

申请号：EP91120674.6

申请日：1987-03-30

申请人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Kveton, Otto Karl ,  Sood, Savtantar Kumar ,  Hawthorne, Samuel Hugh

发明人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Kveton, Otto Karl ,  Sood, Savtantar Kumar ,  Hawthorne, Samuel Hugh

IPC分类号： B01D59/26

CPC分类号： B01D59/24 ,  B01D59/26 ,  C01B4/00 ,  G01N30/20 ,  G01N30/30 ,  G01N2030/025 ,  G01N2030/3007 ,  G01N2030/3023 ,  G01N2030/3084

公开(公告)号：EP0245936B1

公开(公告)日：1994-06-22

申请号：EP87302742.9

申请日：1987-03-30

申请人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Kveton, Otto Karl ,  Sood, Savtantar Kumar ,  Hawthorne, Samuel Hugh

发明人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Kveton, Otto Karl ,  Sood, Savtantar Kumar ,  Hawthorne, Samuel Hugh

IPC分类号： B01D59/26

CPC分类号： B01D59/24 ,  B01D59/26 ,  C01B4/00 ,  G01N30/20 ,  G01N30/30 ,  G01N2030/025 ,  G01N2030/3007 ,  G01N2030/3023 ,  G01N2030/3084

公开(公告)号：EP2585854A4

公开(公告)日：2017-07-12

申请号：EP11797446

申请日：2011-06-22

申请人： OTTO KARL

发明人： OTTO KARL

IPC分类号： G01T1/29 ,  A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/00 ,  A61N5/10 ,  G01T1/29 ,  H05K999/00

摘要： Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.

摘要翻译： 提供了用于允许操纵通过放射递送设备可递送的可实现的剂量分布估计的方法，以用于所提议的治疗受试者。 一种这样的方法包括：确定期望修改剂量值的剂量修改体素和期望剂量修改的对应量值; 对于多个光束中的每个光束：（i）将所述光束表征为小射束的二维阵列，其中每个小射束与对应的强度值和表示所述小射束投影到空间中的射线线相关联; 和（ii）识别具有与剂量修改体素相交的相关射线的一个或多个剂量改变小射束; 修改至少一个剂量改变小束的强度值; 以及更新可实现的剂量分布估计以考虑至少一个剂量改变子束的修改的强度值。

公开(公告)号：EP2585854A1

公开(公告)日：2013-05-01

申请号：EP11797446.9

申请日：2011-06-22

申请人： Otto, Karl

发明人： Otto, Karl

IPC分类号： G01T1/29 ,  A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/00 ,  A61N5/10 ,  G01T1/29 ,  H05K999/00 ,  H05K999/99

摘要： Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.

摘要翻译： 提供了通过一个放射输送装置的受试者的治疗建议允许一个可实现的剂量分布估计交付的操作方法。 一个搜索方法包括：确定性采矿的剂量体素修饰对于其中期望修改剂量值和期望的剂量变形例的相应幅值; 对于每个波束的多个：表征所述光束作为子束的二维阵列（i）中，每个子束worin与对应的强度值和表示子束进入空间的投影射线线相关联; 和（ii）识别具有相关联的射线线并相交的剂量改变体素的一个或多个剂量的变化的子束; 修改所述剂量改变子束中的至少一个的强度值; 和更新可达到的剂量分布估计以考虑剂量变化小射束的所述至少一个的变形强度值。

公开(公告)号：EP0317054A2

公开(公告)日：1989-05-24

申请号：EP88307833.9

申请日：1988-08-24

申请人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Sood, Savtantar Kumar ,  Kveton, Otto Karl ,  Hawthorne, Samuel Hugh

发明人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Sood, Savtantar Kumar ,  Kveton, Otto Karl ,  Hawthorne, Samuel Hugh

IPC分类号： B01D53/02 ,  C01B4/00 ,  B01D59/26

CPC分类号： B01D59/26 ,  B01D53/025 ,  C01B4/00 ,  G01N30/02 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/167 ,  G01N2030/3007 ,  G01N2030/3023 ,  G01N2030/3038 ,  B01D15/40

摘要： A gas chromatography apparatus adapted for large scale separation of gases at low temperture comprises a column packed with a solid adsorbent and having a cooling tube being open at both ends extending centrally through its length. The column is suspended in a pressure vessel so that it may be totally immersed in a liquified gas coolant. The pressure vessel has heating means to maintain the coolant at its boiling point and thereby to regulate the temperature within the vessel by varying the pressure therein. The apparatus has particular application to the large scale separation of hydrogen isotopes.

摘要翻译： 适用于在低温下大规模分离气体的气相色谱装置包括填充有固体吸附剂的柱，并且具有在两端延伸通过其长度的中心的冷却管。 将柱悬浮在压力容器中，使其可以完全浸入液化气体冷却剂中。 压力容器具有加热装置以将冷却剂保持在其沸点，从而通过改变其中的压力来调节容器内的温度。 该装置特别适用于氢同位素的大规模分离。

公开(公告)号：EP1909904A4

公开(公告)日：2012-06-20

申请号：EP06761183

申请日：2006-07-25

申请人： OTTO KARL

发明人： OTTO KARL

IPC分类号： A61N5/10 ,  A61B6/02 ,  A61N5/01

CPC分类号： A61N5/1031 ,  A61B6/032 ,  A61B6/4085 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

公开(公告)号：EP0317054A3

公开(公告)日：1990-11-28

申请号：EP88307833.9

申请日：1988-08-24

申请人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Sood, Savtantar Kumar ,  Kveton, Otto Karl ,  Hawthorne, Samuel Hugh

发明人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Sood, Savtantar Kumar ,  Kveton, Otto Karl ,  Hawthorne, Samuel Hugh

IPC分类号： B01D53/02 ,  C01B4/00 ,  B01D59/26

CPC分类号： B01D59/26 ,  B01D53/025 ,  C01B4/00 ,  G01N30/02 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/167 ,  G01N2030/3007 ,  G01N2030/3023 ,  G01N2030/3038 ,  B01D15/40

摘要： A gas chromatography apparatus adapted for large scale separation of gases at low temperture comprises a column packed with a solid adsorbent and having a cooling tube being open at both ends extending centrally through its length. The column is suspended in a pressure vessel so that it may be totally immersed in a liquified gas coolant. The pressure vessel has heating means to maintain the coolant at its boiling point and thereby to regulate the temperature within the vessel by varying the pressure therein. The apparatus has particular application to the large scale separation of hydrogen isotopes.

公开(公告)号：EP0245936A3

公开(公告)日：1990-05-02

申请号：EP87302742.9

申请日：1987-03-30

申请人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Kveton, Otto Karl ,  Sood, Savtantar Kumar ,  Hawthorne, Samuel Hugh

发明人： Cheh, Christopher Huk-Shi ,  Massey, Ronald Ellard ,  Kveton, Otto Karl ,  Sood, Savtantar Kumar ,  Hawthorne, Samuel Hugh

IPC分类号： B01D59/26

CPC分类号： B01D59/24 ,  B01D59/26 ,  C01B4/00 ,  G01N30/20 ,  G01N30/30 ,  G01N2030/025 ,  G01N2030/3007 ,  G01N2030/3023 ,  G01N2030/3084

摘要： A method for separating hydrogen isotope species by gas chromatography is described. The invention utilizes low temperature chromatography on molecular sieves with peak cutting or temperature programming depending on the particular application. The method provides a much larger throughput capability than was heretofore available. The invention also includes the separation of mixed dimer isotope species from the helium carrier gas by condensation, and storage thereof at low temperature in a non-catalytic environment so that equilibration may be avoided.

公开(公告)号：EP1909904B1

公开(公告)日：2013-09-04

申请号：EP06761183.0

申请日：2006-07-25

申请人： Otto, Karl

发明人： Otto, Karl

IPC分类号： A61N5/10 ,  A61N5/01 ,  A61B6/02

CPC分类号： A61N5/1031 ,  A61B6/032 ,  A61B6/4085 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

公开(公告)号：EP1909904A1

公开(公告)日：2008-04-16

申请号：EP06761183.0

申请日：2006-07-25

申请人： Otto, Karl

发明人： Otto, Karl

IPC分类号： A61N5/10 ,  A61N5/01 ,  A61B6/02

CPC分类号： A61N5/1031 ,  A61B6/032 ,  A61B6/4085 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.