公开(公告)号：EP3123165A1

公开(公告)日：2017-02-01

申请号：EP15717079.6

申请日：2015-03-23

申请人： Boeker, Peter

发明人： Boeker, Peter

IPC分类号： G01N30/54 ,  G01N30/60 ,  G01N30/30

CPC分类号： G01N30/30 ,  G01N30/54 ,  G01N30/6047 ,  G01N2030/3015 ,  G01N2030/3023 ,  G01N2030/3061

摘要： The invention relates to a method, to a device, and to the use of a method for the gas-chromatic separation and determination of volatile substances in a carrier gas by means of a chromatographic separating capillary (1), wherein the separating capillary and/or an enveloping capillary (2) surrounding the separating capillary (1) is electrically conductive and is heated with current in the form of a resistance heater and is cooled by a forced convective flow by means of a fluid in the form of a gradient flow field in such a way that a continuous temperature gradient arises over the length of the separating capillary.

摘要翻译： 本发明涉及一种通过色谱分离毛细管（1）进行气相色谱分离和确定载气中的挥发物质的方法，装置和方法，其中分离毛细管和/ 或围绕分离毛细管（1）的包封毛细管（2）是导电的并且以电阻加热器形式的电流加热，并且通过梯度流场形式的流体的强制对流来冷却 使得分离毛细管的长度上出现连续的温度梯度。

公开(公告)号：EP1344054B1

公开(公告)日：2006-02-01

申请号：EP01984553.6

申请日：2001-11-28

申请人： Thermo Electron S.p.A.

发明人： BEENS, Jan

IPC分类号： G01N30/46

CPC分类号： G01N30/465 ,  G01N30/463 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/3023 ,  G01N2030/623 ,  Y10T436/204998 ,  Y10T436/25875

摘要： This invention relates to a modulator for use in gas chromatographic analysis, adapted for alternatively trapping and releasing fractions of solutes in a length of a capillary column within a chromatographic oven, characterized in that it comprises at least one nozzle placed to spray at least one jet in at least one corresponding place along said capillary column length, said nozzle (s) being connected each to a source of liquid CO2 via a related valve, and means for alternatively opening said valve (s) for a predetermined time, to cause a jet of liquid CO2 to impinge for said predetermined time on said column place and to leave the oven atmosphere to heat said column place after said predetermined time. The modulator can be used in a conventional GC system or in a two dimensional GC system, for modulating the analytes fed to the second capillary column.

公开(公告)号：EP1344054A1

公开(公告)日：2003-09-17

申请号：EP01984553.6

申请日：2001-11-28

申请人： Thermo Finnigan Italia S.p.A.

发明人： BEENS, Jan

IPC分类号： G01N30/46

CPC分类号： G01N30/465 ,  G01N30/463 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/3023 ,  G01N2030/623 ,  Y10T436/204998 ,  Y10T436/25875

摘要： This invention relates to a modulator for use in gas chromatographic analysis, adapted for alternatively trapping and releasing fractions of solutes in a length of a capillary column within a chromatographic oven, characterized in that it comprises at least one nozzle placed to spray at least one jet in at least one corresponding place along said capillary column length, said nozzle (s) being connected each to a source of liquid CO2 via a related valve, and means for alternatively opening said valve (s) for a predetermined time, to cause a jet of liquid CO2 to impinge for said predetermined time on said column place and to leave the oven atmosphere to heat said column place after said predetermined time. The modulator can be used in a conventional GC system or in a two dimensional GC system, for modulating the analytes fed to the second capillary column.

公开(公告)号：EP0906565A1

公开(公告)日：1999-04-07

申请号：EP98918202.0

申请日：1998-04-14

申请人： VARIAN ASSOCIATES, INC.

发明人： LI, Kenneth ,  ROBINSON, John

IPC分类号： G01N30

CPC分类号： G01N30/30 ,  G01N30/12 ,  G01N2030/025 ,  G01N2030/127 ,  G01N2030/3023 ,  G01N2030/3046

摘要： A modular cooling device for gas chromatography analyte sample injectors is embodied in a series of tubes connecting a coolant supply valve to the injector heating block. A flexible supply tube carrying coolant maintains structural integrity up to about 150 °C, has a low thermal conductivity and is connecting a coolant supply, and a transition tube. A transition tube, between the supply tube and the cooling tube, maintains structural integrity up to 450 °C and has a low thermal conductivity. The cooling tube, between the transition tube and an exhaust, has an outer surface that is physically engageable with a heating block surface. It maintains structural integrity up to 450 °C and has a high thermal conductivity (at least about 200 watts/meter °C) to facilitate heat transfer. It further has a flattened surface for greater contact area with the heating block to provide greater cooling effect.

公开(公告)号：EP0590932A3

公开(公告)日：1994-04-27

申请号：EP93307673

申请日：1993-09-28

申请人： PETERS ANITA JO ,  SACKS RICHARD DOUGLAS

发明人： PETERS, ANITA JO ,  SACKS, RICHARD DOUGLAS

IPC分类号： G01N30/08 ,  G01N30/02 ,  G01N30/12 ,  G01N30/30 ,  G01N30/38 ,  G01N30/40 ,  G01N30/62 ,  G01N30/16

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

摘要： A gas chromatography system in which prefocusing of a sample analyte is provided through the use of an adsorbent coated porous layer open tubular trap tube. Through the use of an adsorbent coated collection device low boiling point components can be successfully trapped for preconcentration and injection at temperatures well above that necessary when employing conventional cryo-focusing.

摘要翻译： 一种气相色谱系统，其中通过使用吸附剂涂覆的多孔层开口管式捕集管来提供样品分析物的预聚集。 通过使用吸附剂涂覆的收集装置，可以成功捕集低沸点组​​分，用于在远高于采用常规低温聚焦所必需的温度下进行预浓缩和注射。

公开(公告)号：EP0550957A1

公开(公告)日：1993-07-14

申请号：EP92310119.0

申请日：1992-11-05

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Sacks, Richard Douglas ,  Peters, Anita Jo

IPC分类号： G01N30/20

CPC分类号： G01N30/20 ,  G01N1/2214 ,  G01N1/26 ,  G01N1/40 ,  G01N30/12 ,  G01N30/24 ,  G01N30/40 ,  G01N30/466 ,  G01N30/8651 ,  G01N35/1097 ,  G01N2030/121 ,  G01N2030/122 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/385 ,  G01N2030/402 ,  G01N2030/405 ,  G01N2030/407 ,  G01N2030/623 ,  G01N2030/628 ,  G01N2030/3023 ,  G01N2030/3061

摘要： Several embodiments of gas chromatography systems are disclosed incorporating mechanical sample injection valves. The injection valves incorporate a delivery tube (126) having an outlet which is swept past the inlet of separation columns (128,130,132) to provide a short duration inlet plug into the separation columns. Carrier gas and sample gas flow is managed through valves to prevent inadvertent injection after an injection is desired and to assure that the sample is not contaminated by past sample flow. Embodiments of injections valve are described for providing inputs into several gas chromatography columns. In addition, a gas chromatography system is described in which multiple columns are used which are time multiplexed with a single detector to produce a complex combined chromatogram from the plural columns. By appropriate selection of column characteristics and injection sequence, the resulting chromatogram can provide an overlay of chromatograms which provide good resolution of all the constituents of the mixture of interest within a short analysis time.

摘要翻译： 公开了结合有机械样品注射阀的气相色谱系统的几个实施例。 喷射阀结合了输送管（126），该输送管具有被扫过分离柱（128,130,132）的入口的出口，以将短持续时间的入口塞提供到分离柱中。 载气和样气流量通过阀门进行管理，以防止在需要注入后无意注入，并确保样品未被过去的样品流量污染。 描述了注入阀的实施例用于向几个气相色谱柱提供输入。 另外，描述了一种气相色谱系统，其中使用多个柱子，其与单个检测器时间多路复用以产生来自多个柱子的复合组合色谱图。 通过适当选择色谱柱特性和进样顺序，所得色谱图可以提供色谱图叠加，在短时间内提供所关注混合物所有成分的良好分离度。

公开(公告)号：EP0445967A3

公开(公告)日：1992-07-22

申请号：EP91301648.1

申请日：1991-02-28

申请人： UNIVERSITY OF DAYTON

发明人： Rubey, Wayne A.

IPC分类号： G01N30/30

CPC分类号： G01N30/30 ,  G01N30/60 ,  G01N33/28 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/3023

摘要： Gas chromatographic methods and apparatus are disclosed whereby improved separation times and efficiency are achieved by provision of a rapid transfer of heat or cooling from a heating or cooling source to a chromatographic column. The column (2) is provided within an insulating sheath. A resistance heating element (12) disposed in the sheath and optional heated or cooling gas flow through the sheath is capable of rapidly changing the temperature imparted to the column thereby.

公开(公告)号：EP0375410A3

公开(公告)日：1991-02-06

申请号：EP89313404.9

申请日：1989-12-20

申请人： UNIVERSITY OF DAYTON

发明人： Rubey, Wayne A.

IPC分类号： G01N30/30

CPC分类号： G01N30/30 ,  G01N30/6047 ,  G01N2030/3015 ,  G01N2030/3023

摘要： Gas chromatographic methods and apparatus are disclosed whereby improved separation times and efficiency are achieved by provision of a time-programmable curvilinearly-shaped negative temperature gradient along the length of the chromatographic column (2). The gas phase sample traveling through the column (2) always passes to a column zone having a lower temperature than the previous column zone. Accordingly, upon elution, sample band-widths are compressed. Separation times may be decreased when compared to conventional isothermal or temperature programmed gas chromatography.

公开(公告)号：EP0251306A1

公开(公告)日：1988-01-07

申请号：EP87109432.2

申请日：1987-07-01

申请人： DIAGEN Institut für molekularbiologische Diagnostik GmbH

发明人： Rosenbaum, Volker, Dipl.-Phys. ,  Riesner, Detlev, Prof.-Dr.

IPC分类号： B01D43/00 ,  G01N27/26 ,  B01D57/02 ,  G01N30/90

CPC分类号： C02F9/005 ,  B01D43/00 ,  B01D57/02 ,  B01L7/54 ,  G01N27/44704 ,  G01N30/90 ,  G01N2030/3015 ,  G01N2030/3023 ,  G01N2030/303

摘要： Ein Verfahren und eine Vorrichtung zur Herstellung ei­nes regelbaren reproduzierbaren Temperaturgradienten in einer vorgegebenen Richtung von wärmeleitenden Platten (1) für die Auftrennung von Stoffgemischen in flächigen Trennmedien erfolgt dadurch, daß eine Kante (2) einer Plat­te mittels einer oder mehrerer regelbarer Heizvorrich­tungen (4) erwärmt und die gegenüberliegende Kante (3) der Plat­te mittels einer oder mehrerer regelbarer Kühlvorrich­tungen (5) gekühlt wird, wobei der Energiefluß der Heizvor­richtung(en) (4) einerseits und der Kühlvorrichtung(en) (5) andererseites größer ist als der Energiefluß durch die Platte (1). Dieses Verfahren und diese Vorrichtung sind geeignet zur Auftrennung von Stoffgemischen, in denen mindestens eine Komponente im Temperaturbereich des Temperaturgradienten eine thermische Umwandlung er­fährt. Sie ist daher geeignet zum Nachweis und zur Un­terscheidung von Viroiden, Satelliten-RNAs, Viren mit doppelsträngiger oder zirkulärer Nukleinsäure sowie zur Analyse von Protein-Nukleinsäure-Komplexen und der Ana­lyse von Mutationen.

摘要翻译： 通过一个或多个可控的加热装置手段的板在导热板（1），用于在片材类型的分离介质物质的混合物的分离的预定方向上的温度梯度是通过加热一个边缘（2）成立（4- ）和冷却的相对边缘（3）的板通过的一方面的一个或多个可控制的冷却装置（5），加热装置（一个或多个的能量通量）（4）装置和没有冷却装置的（一个或多个 ）（5）在另一方面小于穿过所述板（1）的能量通量越大。 这种方法和该装置适合于混合物的物质，其中所述分离至少一种组分进入下的温度范围内的温度梯度的热转化。 因此，适合于检测和区分类病毒，与双链核酸的或环状的卫星RNA病毒，以及用于蛋白质/核酸复合物和突变的分析。 ... ...

公开(公告)号：EP3123165B1

公开(公告)日：2018-04-04

申请号：EP15717079.6

申请日：2015-03-23

申请人： Boeker, Peter

发明人： Boeker, Peter

IPC分类号： G01N30/54 ,  G01N30/60 ,  G01N30/30

CPC分类号： G01N30/30 ,  G01N30/54 ,  G01N30/6047 ,  G01N2030/3015 ,  G01N2030/3023 ,  G01N2030/3061