摘要:
A solid pharmaceutical composition for release of a biologically active substance into a desired aqueous environment, containing a core and an outer layer, said core comprising between 17 and 93% by weight of the biologically active substance, between 0.01 and 7% by weight of a water swellable polymer material and between 0 and 83% of one or more accessory ingredients, relative to the total weight of the core; and the outer layer comprising between 25 and 75% by weight of the biologically active substance, between 25 and 75% by weight of a material for enabling rapid dispersion of the outer layer into the aqueous environment and 0 to 50% by weight of one or more accessory ingredients, relative to the total weight of the outer layer. The composition is preferably formulated as a bolus for veterinary use.
摘要:
The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl] pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.
摘要:
A composition comprising the compounds 2,4-diamino-5-(8-dimethylamino-7-methyl-5-quinolylmethyl)pyrimidine and sulphadimethoxine or salts- thereof useful for treating bacterial infections in small domestic animals.
摘要:
The antibiotic compound M139603 (tetronasin), disclosed in GB-A-2027013 as a growth-promotant in farm animals with activity against Gram-positive bacteria, has now been found to prevent and treat Treponem a hyodysenteriae infections in pigs (swine dysentery). Analogues of M139603 have the same action. The compound is administered in the pig's food or water supply.
摘要:
The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl] pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.
摘要:
The antibiotic compound M139603 (tetronasin), disclosed in GB-A-2027013 as a growth-promotant in farm animals with activity against Gram-positive bacteria, has now been found to prevent and treat Treponem a hyodysenteriae infections in pigs (swine dysentery). Analogues of M139603 have the same action. The compound is administered in the pig's food or water supply.
摘要:
A peptide having primary structural homology to a continuous sequence of amino acid residues of growth hormone in the region spanning positions 35 to 53 or antigenically equivalent peptides thereto or salts thereof, may be used in an antigenic formulation to potentate the effects of growth hormone in a vertebrate.
摘要:
The invention relates to improvements in boluses for releasing a biologically active substance into a liquid environment. These boluses comprise a generally elongate core (25) surrounded by a liquid impermeable casing (11), (13), (15). In use, the casing has an opening at one (27) or both ends of the core and is progressively shed as the core retreats, to release the active substance at a rate which varies over at least one time period. The main improvement resides in that the bolus casing is (or at least some of its components are) sufficiently strong to retain integrity without disintegrating in the absence of any support provided by the core.