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公开(公告)号：EP2416792A4
公开(公告)日：2012-10-24
申请号：EP10762568
申请日：2010-04-12
申请人： QI HAIYAN
发明人： QI HAIYAN
IPC分类号： A61K35/74 , A61K31/01 , A61K31/015 , A61K31/047 , A61K31/105 , A61K31/122 , A61K31/155 , A61K31/26 , A61K31/352 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/436 , A61K31/4375 , A61K31/4709 , A61K31/573 , A61K33/06 , A61K36/45 , A61K36/87 , A61K38/22 , G01N33/53
CPC分类号： A61K31/436 , A61K8/49 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/105 , A61K31/122 , A61K31/145 , A61K31/155 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K31/453 , A61K31/4709 , A61K31/567 , A61K31/573 , A61K31/7004 , A61K31/7056 , A61K33/04 , A61K38/063 , A61K45/06 , A61Q19/08 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5079 , G01N33/6875 , G01N33/6893 , G01N2333/39 , G01N2800/02 , Y02A90/26 , A61K2300/00
摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
摘要翻译： 本发明公开了老化过程中的机制，并描述了用于改善线粒体功能，维持衰老和有丝分裂细胞后的细胞周期阻滞状态的药剂，从而预防或治疗与加速的线粒体功能相关的年龄相关疾病或病症 损失，端粒功能障碍和/或生长停滞状态的恶化。 本发明还公开了许多化合物或组合物。 本发明进一步提供低剂量的雷帕霉素或其类似物作为模拟限制热量以防止与年龄有关的疾病或病症的用途。
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公开(公告)号：EP2965763B8
公开(公告)日：2018-08-15
申请号：EP15166498.4
申请日：2010-04-12
申请人： Qi, Haiyan
发明人： Qi, Haiyan
IPC分类号： A61K35/74 , G01N33/53 , A61K31/436 , A61K31/352 , A61K31/047 , A61K31/01 , A61K36/45 , A61K36/87 , A61K33/06 , A61K31/26 , A61K31/105 , A61K31/155 , A61K31/4375 , A61K38/22 , A61K31/573 , A61K31/4709 , A61K31/375 , A61K31/355 , A61K31/015 , A61K31/385 , A61K31/122
CPC分类号： A61K31/436 , A61K8/49 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/105 , A61K31/122 , A61K31/145 , A61K31/155 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K31/453 , A61K31/4709 , A61K31/567 , A61K31/573 , A61K31/7004 , A61K31/7056 , A61K33/04 , A61K38/063 , A61K45/06 , A61Q19/08 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5079 , G01N33/6875 , G01N33/6893 , G01N2333/39 , G01N2800/02 , Y02A90/26 , A61K2300/00
摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
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公开(公告)号：EP2965763B1
公开(公告)日：2018-06-06
申请号：EP15166498.4
申请日：2010-04-12
申请人： Qi, Haiyan
发明人： Qi, Haiyan
IPC分类号： A61K35/74 , G01N33/53 , A61K31/436 , A61K31/352 , A61K31/047 , A61K31/01 , A61K36/45 , A61K36/87 , A61K33/06 , A61K31/26 , A61K31/105 , A61K31/155 , A61K31/4375 , A61K38/22 , A61K31/573 , A61K31/4709 , A61K31/375 , A61K31/355 , A61K31/015 , A61K31/385 , A61K31/122
CPC分类号： A61K31/436 , A61K8/49 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/105 , A61K31/122 , A61K31/145 , A61K31/155 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K31/453 , A61K31/4709 , A61K31/567 , A61K31/573 , A61K31/7004 , A61K31/7056 , A61K33/04 , A61K38/063 , A61K45/06 , A61Q19/08 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5079 , G01N33/6875 , G01N33/6893 , G01N2333/39 , G01N2800/02 , Y02A90/26 , A61K2300/00
摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
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公开(公告)号：EP2965763A9
公开(公告)日：2016-03-02
申请号：EP15166498.4
申请日：2010-04-12
申请人： Qi, Haiyan
发明人： Qi, Haiyan
IPC分类号： A61K35/74 , G01N33/53 , A61K31/436 , A61K31/352 , A61K31/047 , A61K31/01 , A61K36/45 , A61K36/87 , A61K33/06 , A61K31/26 , A61K31/105 , A61K31/155 , A61K31/4375 , A61K38/22 , A61K31/573 , A61K31/4709 , A61K31/375 , A61K31/355 , A61K31/015 , A61K31/385 , A61K31/122
CPC分类号： A61K31/436 , A61K8/49 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/105 , A61K31/122 , A61K31/145 , A61K31/155 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K31/453 , A61K31/4709 , A61K31/567 , A61K31/573 , A61K31/7004 , A61K31/7056 , A61K33/04 , A61K38/063 , A61K45/06 , A61Q19/08 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5079 , G01N33/6875 , G01N33/6893 , G01N2333/39 , G01N2800/02 , Y02A90/26 , A61K2300/00
摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
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公开(公告)号：EP2965763A1
公开(公告)日：2016-01-13
申请号：EP15166498.4
申请日：2010-04-12
申请人： Qi, Haiyan
发明人： Qi, Haiyan
IPC分类号： A61K35/74 , G01N33/53 , A61K31/436 , A61K31/352 , A61K31/047 , A61K31/01 , A61K36/45 , A61K36/87 , A61K33/06 , A61K31/26 , A61K31/105 , A61K31/155 , A61K31/4375 , A61K38/22 , A61K31/573 , A61K31/4709 , A61K31/375 , A61K31/355 , A61K31/015 , A61K31/385 , A61K31/122
CPC分类号： A61K31/436 , A61K8/49 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/105 , A61K31/122 , A61K31/145 , A61K31/155 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K31/453 , A61K31/4709 , A61K31/567 , A61K31/573 , A61K31/7004 , A61K31/7056 , A61K33/04 , A61K38/063 , A61K45/06 , A61Q19/08 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5079 , G01N33/6875 , G01N33/6893 , G01N2333/39 , G01N2800/02 , Y02A90/26 , A61K2300/00
摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
摘要翻译： 本发明公开了老化过程中的机制，并描述了用于改善线粒体功能，维持衰老和有丝分裂细胞后的细胞周期阻滞状态的药剂，从而预防或治疗与加速的线粒体功能相关的年龄相关疾病或病症 损失，端粒功能障碍和/或生长停滞状态的恶化。 本发明还公开了许多化合物或组合物。 本发明进一步提供低剂量的雷帕霉素或其类似物作为模拟限制热量以防止与年龄有关的疾病或病症的用途。
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公开(公告)号：EP2416792A2
公开(公告)日：2012-02-15
申请号：EP10762568.3
申请日：2010-04-12
申请人： Qi, Haiyan
发明人： Qi, Haiyan
IPC分类号： A61K35/74 , G01N33/53 , A61K31/436 , A61K31/352 , A61K31/047 , A61K31/01 , A61K36/45 , A61K36/87 , A61K33/06 , A61K31/26 , A61K31/105 , A61K31/155 , A61K31/4375 , A61K38/22 , A61K31/573 , A61K31/4709 , A61K31/375 , A61K31/355 , A61K31/015 , A61K31/385 , A61K31/122
CPC分类号： A61K31/436 , A61K8/49 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/105 , A61K31/122 , A61K31/145 , A61K31/155 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4045 , A61K31/453 , A61K31/4709 , A61K31/567 , A61K31/573 , A61K31/7004 , A61K31/7056 , A61K33/04 , A61K38/063 , A61K45/06 , A61Q19/08 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5079 , G01N33/6875 , G01N33/6893 , G01N2333/39 , G01N2800/02 , Y02A90/26 , A61K2300/00
摘要： The present invention discloses mechanisms in the aging process and describes agents to be used for improving mitochondrial function, maintaining the cell cycle- arrested state in senescent and post mitotic cells, and thus preventing or treating age- related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
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