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75 条记录 (耗时 0.021 秒)

    Sustained release formulation of a peptide complexed with a polymer
    7.
    发明公开
    Sustained release formulation of a peptide complexed with a polymer 有权
    组合物与聚合物复合的肽的延迟释放

    公开(公告)号：EP1348444A3

    公开(公告)日：2004-03-24

    申请号：EP03076829.5

    申请日：2000-08-16

    申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

    发明人： Moreau, Jacques-Pierre

    IPC分类号： A61K47/48

    CPC分类号： A61K47/62 ,  A61K47/593

    摘要： This invention pertains to a sustained release complex, Compound (I), which comprises Compound (A), having formula (A) or a pharmaceutically acceptable salt thereof and a copolymer comprising poly-(I)-lactic-glycolic-tartaric acid (P(I)LGT), wherein the amino group of said Compound (A) is ionically bound to a carboxyl group of the P(I)LGT. The present invention further pertains to a process for making said substantial release complex. Further still, the present invention is directed to a pharmaceutical composition comprising said sustained release complex and a pharmaceutically acceptable carrier(s).

    Method of treating hyperprolactinemia and prolactinomas
    8.
    发明公开
    Method of treating hyperprolactinemia and prolactinomas 失效
    Methode zur Behandlung vonHyperprolaktinämiaund Prolaktinomen

    公开(公告)号：EP1332762A1

    公开(公告)日：2003-08-06

    申请号：EP03005548.7

    申请日：1998-04-24

    申请人： Cedars-Sinai Medical Center ,  SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

    发明人： Melmed, Shlomo ,  Shimon, Ilan ,  Culler, Michael D.

    IPC分类号： A61K38/31 ,  A61P5/08 ,  A61P35/00

    CPC分类号： A61K38/31

    摘要： A method of treating hyperprolactinemia in an animal, including a human, administers one or more somatostatin type-5 receptor agonist(s) to, for example, lower abnormally high levels of prolactin in the blood of the animal. A method of treating a subject, including a human, afflicted by a prolactinoma, administers one or more type-5 receptor selective agonist(s) to, for example, lower prolactin secretion and/or decrease tumor size in the subject.

    摘要翻译： 一种在动物（包括人）中治疗高泌乳素血症的方法，将一种或多种生长抑素类型5受体激动剂施用于例如动物血液中异常高水平的催乳素水平。 治疗由催乳素瘤患者的受试者（包括人）的方法，施用一种或多种5型受体选择性激动剂，例如降低催乳素分泌和/或减少受试者的肿瘤大小。