公开(公告)号：EP0388654A2

公开(公告)日：1990-09-26

申请号：EP90103465.2

申请日：1990-02-22

申请人： STERLING DRUG INC.

发明人： Bailey, Denis Mahlon ,  Powles, Ronald George

IPC分类号： C07D231/12 ,  A61K31/415

CPC分类号： C07D231/22

摘要： N-[(alkylamino)alkyl]3,4 (or 4,5)-diaryl-1H-­pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-­acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

摘要翻译： 可用于治疗哺乳动物心律失常的N - [（烷基氨基）烷基] 3,4（或4,5） - 二芳基-1H-吡唑-1-（支链）烷酰胺和吡唑-1-烷胺通过使下 - 吡唑-1-乙酸的烷基酯与适当的二胺反应，然后还原或通过使吡唑-1-乙酸的低级烷基酯的阴离子与烷基化剂反应，然后通过合适的胺置换酯 。

公开(公告)号：EP0374471A1

公开(公告)日：1990-06-27

申请号：EP89121095.7

申请日：1989-11-14

申请人： STERLING DRUG INC.

发明人： Fuggini, Cynthia Leacock ,  Streit, Allan Lee

IPC分类号： C11D1/94 ,  C11D3/36 ,  C11D3/37

CPC分类号： C11D3/3742 ,  C11D1/523 ,  C11D1/72 ,  C11D1/94 ,  C11D3/364

摘要： Compositions for cleaning hard surfaces, which are formulated to leave on the surface simultaneously with the cleaning thereof a protective barrier layer which serves to protect the surface against further soil deposition comprising: (A), as cleaning agents, from one to two nonionic surfactants and an amphoteric surfactant; (B) as protective barrier components, lecithin and an aminofunctional polydimethylsiloxane copolymer; (C), as solvency and grease cutting agents, from one to two glycols; and (D) water.

摘要翻译： 用于清洁硬表面的组合物，其被配制为在其表面上同时留下保护性阻隔层，其用于保护表面免受另外的污垢沉积，包括：（A）作为清洁剂，从一种至两种非离子表面活性剂和 两性表面活性剂; （B）作为保护屏障成分，卵磷脂和氨基官能聚二甲基硅氧烷共聚物; （C），作为偿付能力和油脂切割剂，一至二元醇; 和（D）水。

公开(公告)号：EP0361239A2

公开(公告)日：1990-04-04

申请号：EP89117129.0

申请日：1989-09-15

申请人： STERLING DRUG INC.

发明人： Keister, Don Mark

IPC分类号： A61K31/565

CPC分类号： A61K31/565

摘要： The method of increasing ovulation rate and litter size in swine which comprises administering to a gilt or sow during the middle to late part of the estrus cycle an amount of epostane sufficient to increase follicular recruitment and thereby increase the number of ova released by the ovaries and, after insemination, to increase the number of viable fertilized ova implanted in the uterus and, after gestation, to increase the number of live piglets delivered is described.

摘要翻译： 在猪中增加排卵率和排卵量的方法，其包括在发情周期的中期至晚期部分给予镀金或母猪一定量的足够增加滤泡募集的epostane，从而增加卵巢释放的卵的数量， 在授精后，增加植入子宫中的受精卵的数量，并且在妊娠后增加递送的活仔猪的数量。

公开(公告)号：EP0108380B1

公开(公告)日：1989-02-22

申请号：EP83110912.9

申请日：1983-11-02

申请人： STERLING DRUG INC.

发明人： Lesher, George Yohe ,  Singh, Baldev ,  Laskowski, Stanley Chester

IPC分类号： C07D471/04 ,  A61K31/505

CPC分类号： C07D239/42 ,  C07D319/06 ,  C07D407/12 ,  C07D407/14 ,  C07D471/04

公开(公告)号：EP0299407A1

公开(公告)日：1989-01-18

申请号：EP88111051.4

申请日：1988-07-11

申请人： STERLING DRUG INC.

发明人： Bailey, Denis Mahlon

IPC分类号： C07D231/12 ,  A61K31/415

CPC分类号： C07D231/12 ,  C07D231/22

摘要： N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-­1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester or pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an ω-­aminoalkanol, followed by activation of the alcohol and displacement of an appropriate amine.

摘要翻译： 可用于治疗哺乳动物心律失常的N - [（二取代氨基）烷基] -3,4（或4,5） - 二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺通过使下 - 烷基酯或吡唑-1-乙酸或丙酸与适当的二胺反应，或通过使吡唑-1-乙酸或丙酸的低级烷基酯与ω-氨基链烷醇反应，然后活化醇并置换 适当的胺。

公开(公告)号：EP0253099A2

公开(公告)日：1988-01-20

申请号：EP87107212.0

申请日：1987-05-18

申请人： STERLING DRUG INC.

发明人： Keister, Don Mark

IPC分类号： A61K31/565

CPC分类号： A61K31/565 ,  Y10S514/874

摘要： The method of regulating fertility in swine which comprises administering to a pregnant sow near term an amount of epostane sufficient to induce parturition of live piglets on the following day.

摘要翻译： 一种调节猪繁殖力的方法，包括对怀孕母猪近期施用一定量的足以诱导活仔猪分娩的异丙酚的量。

公开(公告)号：EP0171037A3

公开(公告)日：1987-08-26

申请号：EP85109689

申请日：1985-08-01

申请人： STERLING DRUG INC.

发明人： Bell, Malcolm Rice

IPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06

CPC分类号： C07D231/12 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06

摘要： 3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcar- bony or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalka- necarbonyl-1-tosyloxyalkyl- or haloalkyl-1H-indole with an amine.

公开(公告)号：EP0215430A2

公开(公告)日：1987-03-25

申请号：EP86112475.8

申请日：1986-09-09

申请人： STERLING DRUG INC.

发明人： Courtney, Andrew Steven

IPC分类号： E03D9/03 ,  E03D9/02

CPC分类号： E03D9/037 ,  E03D2009/024

摘要： A dispenser for automatically metering a liquid-soluble or liquid-suspendible material into a liquid environment in response to a rise and fall in the level of the liquid which comprises a buoyant container adapted for holding the material to be dispensed, said container being adapted for pivotal mounting on an axis which is offset from the axis of the center of buoyancy of said container by an amount from greater than 0% up to about 200% of the distance, a measured along a line through the pivot axis, between said center of buoyancy axis and the outer perimeter of said container, said container having one or more openings in a wall thereof located below the center of buoyancy of said container.

摘要翻译： 一种分配器，用于响应液体的上升和下降而自动计量液体或液体可悬挂物质进入液体环境，液体水平包括适于保持待分配材料的浮力容器，所述容器适于 枢转安装在轴线上，该轴线从所述容器的浮力中心的轴线偏移大于距离的0％至约200％的量，该距离沿着穿过枢转轴线的线在所述中心 浮力轴线和所述容器的外周边，所述容器在其位于所述容器的浮力中心下方的壁中具有一个或多个开口。

公开(公告)号：EP0075116B1

公开(公告)日：1985-05-22

申请号：EP82107603.1

申请日：1982-08-19

申请人： STERLING DRUG INC.

发明人： Singh, Baldev

IPC分类号： C07D213/85

CPC分类号： C07D213/85

公开(公告)号：EP0110366A2

公开(公告)日：1984-06-13

申请号：EP83111899.7

申请日：1983-11-28

申请人： STERLING DRUG INC.

发明人： Hung, William Mo-Wei ,  Ehlinger, Edward Elzmer

IPC分类号： C07D493/10 ,  C07D213/38 ,  B41M5/12 ,  B41M5/26

CPC分类号： C07D493/10 ,  B41M5/1455 ,  B41M5/3275 ,  C07D207/12 ,  C07D213/38

摘要： 2- and/or 6-pyridylethylamino-substituted fluorans useful as color formers, particularly in pressure-sensitive carbonless duplicating systems and thermal-responsive marking systems are prepared by the interaction of (pyridylethylaminophe- nyl)carbonylbenzoic acids with 4-hydroxy- or alkoxyanilines or by the interaction of (disubstituted aminophenyl)carbonylben- zoic acids with N-pyridylethyl-4-hydroxy- or alkoxy acetanilides. The (pyridylethylaminophenyl)carbonylbenzoic acid intermediates required for the fluorans are prepared by interacting a N-pyridylethyl-3-hydroxyaniline with a substituted or unsubstituted phthalic anhydride. The N-pyridylethyl-4-hydroxy-or alkoxyanilines and the N-pyridylethyl-3-hydroxyanilines are prepared by interacting the respective aniline with a vinylpyridine.

摘要翻译： 可用于成色剂的2-和/或6-吡啶基乙基氨基取代的荧烷，特别是在压敏无碳复制体系和热响应标记体系中，通过（吡啶基乙基氨基苯基）羰基苯甲酸与4-羟基 - 或烷氧基苯胺的相互作用或通过 （二取代的氨基苯基）羰基苯甲酸与N-吡啶基乙酰基-4-羟基 - 或烷氧基乙酰苯胺的相互作用。 通过使N-吡啶基乙基-3-羟基苯胺与取代或未取代的邻苯二甲酸酐相互作用来制备荧光体所需的（吡啶基乙基氨基苯基）羰基苯甲酸中间体。 通过使相应的苯胺与乙烯基吡啶相互作用来制备N-吡啶基乙基-4-羟基 - 或烷氧基苯胺和N-吡啶基-3-羟基苯胺。