公开(公告)号：EP3973550B1

公开(公告)日：2024-01-31

申请号：EP20732663.8

申请日：2020-05-20

发明人： AFONSO ROQUE, Ana Cecília ,  MARQUES ESTEVES, Carina Alexandra ,  VINCENT ULIJN, Rein

IPC分类号： H01B1/12

公开(公告)号：EP2885413B1

公开(公告)日：2019-06-19

申请号：EP13829454.1

申请日：2013-08-15

申请人： The Research Foundation of the City University of New York

发明人： WURTZEL, Eleanore, T. ,  SHUMSKAYA, Maria

IPC分类号： C12N15/82

公开(公告)号：EP1994688B1

公开(公告)日：2013-06-12

申请号：EP07715679.2

申请日：2007-03-15

申请人： Samsung Electronics Co., Ltd. ,  The Research Foundation of the City University of New York

发明人： ZHENG, Jianliang Samsung Electronics Co., Ltd. ,  JUNG, Jin-Sae Samsung Electronics Co., Ltd. ,  LEE, Myung-Jong Samsung Electronics Co., Ltd.

IPC分类号： H04L12/28 ,  H04L12/70

CPC分类号： H04L45/48 ,  H04L45/00 ,  H04L45/04 ,  H04L45/28 ,  H04L45/54 ,  H04W40/24 ,  H04W40/30

公开(公告)号：EP2076129A2

公开(公告)日：2009-07-08

申请号：EP07852691.0

申请日：2007-10-12

申请人： The Research Foundation of the City University of New York

发明人： RAJA, Krishnaswami ,  BANERJEE, Probal ,  AUERBACH, Andrew ,  SHI, Wei ,  L'AMOREAUX, William

IPC分类号： A01N43/20 ,  A01N43/24 ,  A61K31/335

CPC分类号： C07C229/12 ,  A61K8/37 ,  A61K8/39 ,  A61K8/496 ,  A61K8/8147 ,  A61K2800/522 ,  A61K2800/56 ,  A61Q19/02 ,  C07C49/248 ,  C07C49/255 ,  C07C69/52 ,  C07C69/602 ,  C07C247/04 ,  C07D249/04

摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.

公开(公告)号：EP2012819A2

公开(公告)日：2009-01-14

申请号：EP07774572.7

申请日：2007-03-30

申请人： The Research Foundation of the City University of New York

发明人： FILBIN, Marie, T. ,  HANNILA, Sari, S.

IPC分类号： A61K38/57 ,  A61P25/28

CPC分类号： A61K38/57

摘要： The present invention provides methods for stimulating neuronal survival, growth and regeneration by administering SLPIs to animals, such as humans. These methods can be used to treat a variety of neurological conditions such as neural injuries and degenerative diseases in subjects in need thereof.

公开(公告)号：EP1849194A2

公开(公告)日：2007-10-31

申请号：EP06733893.9

申请日：2006-01-25

申请人： The Research Foundation of the City University of New York

发明人： ALFANO, Robert, R. ,  PETRICEVIC, Vladimir ,  BYKOV, Alexey

IPC分类号： H01L33/00

CPC分类号： H01S3/0627 ,  C30B19/02 ,  C30B29/34 ,  H01S3/0405 ,  H01S3/0604 ,  H01S3/063 ,  H01S3/09415 ,  H01S3/1623 ,  H01S3/1655 ,  H01S3/1658 ,  H01S3/1675

摘要： A laser medium includes a single crystal of Cr4+:Mg2-xMxSi1-yAy04, where, where M is a tetravalent ion having an ionic radius larger than Mg2+, and A is a divalent ion having an ionic radius larger than Si4+. In addition, either a) 0≤x

公开(公告)号：EP4395834A1

公开(公告)日：2024-07-10

申请号：EP22865525.4

申请日：2022-08-31

申请人： Duke University ,  The Research Foundation of the City University of New York

发明人： ZALUTSKY, Michael ,  FENG, Yutian ,  VAIDYANATHAN, Ganesan ,  ZEGLIS, Brian ,  SARRETT, Samantha

IPC分类号： A61K47/68 ,  C07D271/113 ,  A61K51/04 ,  A61K51/10

CPC分类号： C07D271/113 ,  A61K51/1051

公开(公告)号：EP3104856A1

公开(公告)日：2016-12-21

申请号：EP15749116.8

申请日：2015-02-11

申请人： The City University Of New York Represented By The Research Foundation Of The City University Of New York ,  Cyprus University of Technology

发明人： KASHFI, Khosrow ,  FOTOPOULOS, Vasileios

IPC分类号： A61K31/385

摘要： A method of reducing cellular damage to a plant by treating the plant with a compound containing an NO-releasing moiety and an H2S-releasing moiety covalently bonded to an aspirin derived core or a NOSH compound is claimed. The compounds may also be used in a method of priming a plant against abiotic stress factors and a method of promoting plant growth.

摘要翻译： 通过用含有的NO释放部分的化合物处理植物减少到植物细胞损伤和H 2 S - 释放部分的方法，共价结合到在阿司匹林衍生芯或NOSH化合物主张的内容。 化合物因此可以在吸对非生物应力因素的植物和宣传婷植物生长的方法的方法中使用。

公开(公告)号：EP1551228B1

公开(公告)日：2012-10-03

申请号：EP03760354.5

申请日：2003-06-13

申请人： New York University ,  The Research Foundation of the City University of New York

发明人： TSUJI, Moriya ,  FRANCK, Richard, W. ,  YANG, Guangli ,  CHEN, Guangwu

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H5/04 ,  C07H5/06 ,  C07H7/06 ,  C07H7/00 ,  C07H15/10

CPC分类号： C07H5/06 ,  C07H7/00 ,  C07H15/10

公开(公告)号：EP1278537B1

公开(公告)日：2009-01-14

申请号：EP01932977.0

申请日：2001-05-04

申请人： The Research Foundation of the City University of New York ,  Beth Israel Deaconess Medical Center

发明人： Filbin, Marie T. ,  RATAN, Rajiv R.

IPC分类号： A61K38/50 ,  A61K38/18 ,  A61K38/20 ,  A61K31/70 ,  A61K31/557 ,  A61K48/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K31/7076 ,  A61K31/00 ,  A61K31/5575 ,  A61K38/185 ,  A61K38/50 ,  A61K48/00 ,  G01N33/5008 ,  G01N33/5026 ,  G01N33/5058 ,  G01N2333/475

摘要： This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided.

摘要翻译： 本发明涉及精氨酸酶的新颖鉴定为酶活性的哪个可逆转神经元再生的抑制在中枢和外周神经系统。测定来监测精氨酸酶表达的各种试剂的影响，从而对神经元再生和修复，并确定剂 whichwill阻断或促进提供对神经元生长的抑制作用。 本发明因此涉及组合物和使用试剂也可以反向影响通过精氨酸酶的活性或腐胺和衍生物的聚胺水平神经元神经髓鞘再生的抑制作用的方法。 用于调节和用于促销婷（或抑制）在神经系统的神经元的生长或再生方法，用于治疗受伤或神经组织或神经元损伤，和方法用于治疗与病症，障碍或疾病相关的神经变性，其包括给予所述步骤方法 至少gemäß本发明的组合物中的一个，提供。