-
1.发明公开
公开(公告)号：EP4434538A1
公开(公告)日：2024-09-25
申请号：EP23162925.4
申请日：2023-03-20
申请人： Koch, Philipp , Schmidt, Malin
发明人： Koch, Philipp , Schmidt, Malin
IPC分类号： A61K38/48 , A61K38/49 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/30 , G01N33/50 , A61K31/00
CPC分类号： A61K38/484 , C12Y304/21007 , C12Y304/21031 , A61K38/49 , A61K38/482 , C12Y304/21068 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/30 , A61K31/00 , G01N33/6896 , G01N2800/3020130101 , G01N33/5058 , G01N33/94
摘要： The present invention relates to at least one of a protein selected from group consisting of uPA, tPA, plasminogen, plasmin, and functional fragments thereof, or a nucleic acid encoding said uPA, tPA, plasminogen, plasmin, and functional fragments thereof for use in the prevention or treatment of a psychiatric disorder or disease in a subject. The present invention further relates to a method for identifying a compound that increases the expression, amount and/or biological activity of a protein of the AIIt complex and/or PLGRKT in a cell of a subject, in particular a neuronal cell, such as, for example, a human induced pluripotent stem cell-derived neuronal cell. Further provides are pharmaceutical compositions for use in medicine, in particular for use in the prevention or treatment of a psychiatric disorder or disease in a subject. Further provided are methods for improving or amplifying the therapeutic effect of electroconvulsive therapy (ECT), psychotherapy or a compound in the prevention or treatment of a psychiatric disorder or disease in a subject. Preferably the improvement or amplification of the therapeutic effect is synergistic.
-
公开(公告)号：EP3655774B1
公开(公告)日：2024-09-25
申请号：EP18743736.3
申请日：2018-07-16
CPC分类号： G01N33/5058 , C12N5/0623 , C12N2501/59920130101 , C12N2501/6020130101
-
公开(公告)号：EP4413147A1
公开(公告)日：2024-08-14
申请号：EP22879537.3
申请日：2022-10-07
发明人： CHEN, Ina , GEROLD, Jeff , HOLTH, Jerrah , LAPAN, Sylvain , LIN, Kathy, S. , WOLOCK, Samuel
IPC分类号： C12N15/86 , C07K14/005 , C07K14/01
CPC分类号： C07K14/005 , C12N15/86 , C12N2750/1412220130101 , C12N2750/1414320130101 , C12N2750/1414520130101 , A61K48/0041 , A61K48/005 , A61K38/00 , G01N33/56983 , G01N33/5058
-
4.发明公开
公开(公告)号：EP3409115A2
公开(公告)日：2018-12-05
申请号：EP17184047.3
申请日：2014-03-14
IPC分类号： A01N37/02 , A01N31/02 , A01N31/06 , A01N35/02 , A01N33/04 , A01N35/06 , A01N35/08 , A01N37/42 , A01N41/10 , A01N43/08 , A01N43/10 , A01N43/36 , G01N33/50
CPC分类号： G01N33/5058 , A01N31/02 , A01N31/06 , A01N33/04 , A01N35/02 , A01N35/06 , A01N35/08 , A01N37/02 , A01N37/42 , A01N41/10 , A01N43/08 , A01N43/10 , A01N43/36 , G01N33/5032 , A01N35/04 , A01N43/78
摘要： Provided herein are screening methods for identifying compounds for use as an arthropod repellent based on the masking or inhibition of the detection of the skin odor by a cpA neuron. Provided herein are also screening methods for identifying compounds for use as an arthropod attractant based on activation of the cpA neuron. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.
-
公开(公告)号：EP3080611B1
公开(公告)日：2018-11-14
申请号：EP14870444.8
申请日：2014-12-12
发明人： HYMAN, Bradley , TAKEDA, Shuko
CPC分类号： C07K14/47 , C07K14/4711 , C07K16/18 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835
摘要： The disclosure provides novel forms of tau species and applications thereof, as well as methods of diagnosing and/or treating tau-associated neurodegeneration. the inventors have shown that tau-null neurons lacked activation of AP-induced mitochondrial intrinsic caspase cascades in the neurons and were subsequently protected from A3-induced dendritic spine loss and neurodegeneration. Accordingly, embodiments of various aspects described herein relate to compositions comprising soluble HMW tau species that is responsible for inter-neuron propagation and applications thereof. Methods of treating and diagnosing tau-associated neurodegeneration in a subject are also provided herein.
-
公开(公告)号：EP3369827A1
公开(公告)日：2018-09-05
申请号：EP18155000.5
申请日：2009-03-12
发明人： HEINTZ, Nathaniel , GREENGARD, Paul , HEIMAN, Myriam , SCHAEFER, Anne , DOYLE, Joseph P.n , DOUGHERTY, Joseph D.
CPC分类号： C12N15/62 , A01K67/0278 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C12N15/111 , C12N2320/12 , G01N33/5023 , G01N33/5058 , G01N2800/285
摘要： The invention provides methods and compositions are provided for translational profiling and molecular phenotyping of specific tissues, cells and cell subtypes of interest. The methods provided herein facilitate the analysis of gene expression in the selected subset present within a heterogeneous sample.
-
7.发明授权
公开(公告)号：EP2436387B1
公开(公告)日：2018-07-25
申请号：EP10780502.0
申请日：2010-05-24
申请人： Celgene Corporation
发明人： HANDA, Hiroshi , ANDO, Hideki , ITO, Takumi , HOTTA, Kentaro
IPC分类号： A61K35/12 , A61K35/30 , A61K35/76 , A61K38/45 , A61K48/00 , A61P25/28 , C12Q1/02 , C12Q1/25 , C12N5/10 , C12N9/00 , C12N15/09 , G01N33/50
CPC分类号： C12N9/48 , A61K38/00 , A61K38/45 , C07K14/4705 , C07K14/475 , C07K19/00 , C07K2319/43 , C12N9/93 , C12Y304/00 , C12Y603/02019 , G01N33/5058 , G01N2500/04 , G01N2800/28
摘要： With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or a neural progenitor cell in which CRBN is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using CRBN, are provided.
-
公开(公告)号：EP3348631A1
公开(公告)日：2018-07-18
申请号：EP16844465.1
申请日：2016-09-08
发明人： ANDO, Satoshi , KURODA, Takao , SASAI, Yoshiki
IPC分类号： C12N5/071 , A61K35/30 , C12N5/0735 , C12N5/074 , C12N5/0793 , C12N5/10 , C12Q1/02 , A61K35/545
CPC分类号： C12N5/0621 , A61K35/30 , A61K35/545 , C12N5/10 , C12N2500/90 , C12N2501/115 , C12N2501/155 , C12N2501/41 , C12N2501/727 , C12N2506/45 , C12N2513/00 , C12Q1/02 , G01N33/5014 , G01N33/5058
摘要： The present invention provides a production method of a retinal cell or retinal tissue, including the following steps:
(1) a first step of culturing mammalian pluripotent stem cells in the absence of a feeder cell for a period not exceeding 30 days in a medium comprising 1) a factor for maintaining an undifferentiated state and 2) an MEK inhibitor,
(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and
(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.-
公开(公告)号：EP2114167B1
公开(公告)日：2018-07-11
申请号：EP08727763.8
申请日：2008-01-16
IPC分类号： A01N63/00 , A01N65/00 , A61K48/00 , A01K67/00 , A01K67/033 , A01K67/027 , G01N33/00 , C12N5/073
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2207/15 , A01K2217/15 , A01K2227/105 , A01K2267/0356 , C12N5/0623 , G01N33/5058 , G01N33/5088
摘要： The present invention is directed to a non-human mammal with at least 30% of all of its glial cells in its corpus callosum being human glial cells and/or at least 5% of all of its glial cells in the white matter of its brain and/or brain stem being human glial cells. Methods of producing and using the non-human mammal are also disclosed.
-
公开(公告)号：EP3332695A1
公开(公告)日：2018-06-13
申请号：EP16203153.8
申请日：2016-12-09
发明人： Serwane, Friedhelm , Spatz, Joachim
IPC分类号： A61B5/00 , C12N5/0793 , C12N5/079
CPC分类号： G01N33/4833 , A61B5/0071 , A61B5/4836 , C12N5/0062 , C12N5/062 , C12N5/0621 , C12N2506/45 , C12N2513/00 , C12N2527/00 , G01J1/0407 , G01J1/42 , G01N33/5058 , G01N33/5082
摘要： A measurement device 100 comprises neuronal, in particular retinal, tissue 110 grown from stem cells, the neuronal tissue 110 having a three-dimensional shape neuronal cells that change an electric potential in cells of the neuronal tissue 110 in response to influences that act on the neuronal cells, and a read-out device 130 that is configured to measure neuronal responses of the neuronal tissue 110 via changes in the electric potential generated by the neuronal cells.
-
-
-
-
-
-
-
-
-
搜索结果
745 条记录 (耗时 0.042 秒)
