公开(公告)号：EP3589295B1

公开(公告)日：2024-09-11

申请号：EP18761400.3

申请日：2018-02-28

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61K31/26 ,  A61K39/385 ,  C07K14/435 ,  C07K19/00 ,  A61K39/00 ,  A61P35/00 ,  C07K16/30 ,  A61K39/39

CPC分类号： C07K14/705 ,  C07K14/70503 ,  C07K16/28 ,  C07K16/30 ,  A61K2039/50520130101 ,  C07K2317/62220130101 ,  C07K2319/0320130101 ,  C07K2319/03320130101 ,  A61P35/00 ,  A61K2039/54520130101 ,  A61K39/39 ,  A61K47/545 ,  A61K47/551 ,  A61K39/464402 ,  A61K39/4646 ,  A61K2239/4620230501 ,  A61K39/4631 ,  A61K2239/3820230501 ,  A61K2239/3120230501 ,  A61K2239/4920230501 ,  A61K39/4611 ,  A61K39/464495

公开(公告)号：EP4375292A1

公开(公告)日：2024-05-29

申请号：EP22846274.3

申请日：2022-07-21

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： KIM, Tae-Don ,  LEE, Sooyun

IPC分类号： C07K14/705 ,  C07K16/28 ,  C07K16/32 ,  A61P35/00 ,  A61K35/17

CPC分类号： C07K14/705 ,  C07K16/32 ,  C07K16/28 ,  A61P35/00 ,  A61K2239/2920230501 ,  A61K39/464406 ,  C12N5/0646 ,  A61K2239/2220230501 ,  A61K39/4646 ,  C12N5/0636 ,  A61K39/4613 ,  A61K39/4631 ,  A61K39/464404 ,  A61K39/464422

摘要： The present invention relates to: a novel chimeric antigen receptor containing, as an intracellular signaling domain, an intracellular domain of a receptor containing a dead region; and immune cells expressing the chimeric antigen receptor. In environments in which normal cells are present, the immune cells expressing the chimeric antigen receptor according to the present invention exhibit little or no cytotoxicity and cell death of the immune cells is exhibited, thus ensuring the stability of the normal cells. Conversely, in environments in which target cells are present, the immune cells exhibit more potent cytotoxicity than with conventional techniques utilizing a lone chimeric antigen receptor.