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1.发明公开PROCESS FOR TRANSITION METAL-CATALYZED ASYMMETRIC HYDROGENATION OF ACRYLIC ACID DERIVATIVES, AND A NOVEL CATALYST SYSTEM FOR ASYMMETRIC TRANSITION METAL CATALYSIS 有权方法的过渡金属催化的不对称过渡金属催化丙烯酸衍生物的不对称氢化和新催化剂体系
公开(公告)号：EP1830958A1
公开(公告)日：2007-09-12
申请号：EP05817279.2
申请日：2005-12-05
发明人： BOOGERS, Jeroen , FELFER, Ulfried , KOTTHAUS, Martina , DE VRIES, Andreas, H., M. , DE VRIES, Johannes, G. , LEFORT, Laurent , STEINBAUER, Gerhard
CPC分类号： C07C51/36 , B01J31/1865 , B01J31/187 , B01J31/24 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07C67/303 , C07C57/36 , C07C57/58 , C07C53/128 , C07C59/64
摘要： A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.
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3.发明公开Verfahren zur Herstellung von Alkyl- und Arylmalonsäuren 失效Verfahren zur Herstellung von Alkyl- undArylmalonsäuren
公开(公告)号：EP0873984A1
公开(公告)日：1998-10-28
申请号：EP98103918.3
申请日：1998-03-05
摘要： Die Erfindung betrifft ein neues Verfahren zur Herstellung von Alkyl- und Arylmalonsäuren der Formel
durch alkalische Verseifung der entsprechenden Ester. Dabei erfolgt die Hydrolyse mit Alkalihydroxid in gesättigter Alkalisalzlösung, worauf mit einer Mineralsäure angesäuert und ausgefälltes Alkalisalz abgetrennt wird. Die Produkte werden anschließend aus der wäßrigen Lösung extrahiert.
Das Verfahren ermöglicht eine einfache Abtrennung von Alkalisalzen in kristalliner Form. Wäßrige Lösungen und organische Extraktionsmittel können direkt wiederverwendet werden.摘要翻译： 通过相应的1-4C烷基酯（II）的碱皂化制备式（I）的烷基 - 或芳基 - 丙二酸包括：（i）使用溶解在90-100％ 饱和碱金属盐溶液; （ii）用无机酸酸化反应混合物; （iii）除去沉淀的碱金属盐; 和（iv）用有机溶剂从水溶液中萃取得到（I）。 HOOC-C（R1）（R2）-COOH（I）R1 = H，1-12C烷基，苯基，1-4C烷基苯基或2-4C二烷基苯基; 和R 2 = 1-12C烷基，苯基，1-4C烷基苯基或2-4C二烷基苯基; 或R1 + R2 = CH2CH2。
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4.发明公开MALONIC ACID DI-SALTS AND A METHOD FOR PREPARING MALONYL DIHALIDES 审中-公开丙二酸二乙酯二盐及其制造方法MALONYLDIHALOGENIDEN
公开(公告)号：EP2791107A1
公开(公告)日：2014-10-22
申请号：EP12808629.5
申请日：2012-12-13
发明人： ZHANG, Wenming , ANNIS, Gary, David
IPC分类号： C07C257/06 , C07D487/04 , C07C57/34 , C07C51/60 , C07C57/72
CPC分类号： C07D471/04 , C07C51/60 , C07C55/36 , C07C57/34 , C07C57/36 , C07D213/55 , C07C57/72
摘要： A compound of Formula 2 is disclosed wherein R1, MA and MB are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 1 wherein R1 and X are as defined in the disclosure comprising contacting a compound of Formula 2 with a halogenating agent. Also disclosed is a method for preparing a compound of Formula 4 wherein R1, R3 and R4 are as defined in the disclosure, comprising reacting a compound of Formula 5 wherein R3 and R4 are as defined in the disclosure with a compound of Formula 1, with a compound of Formula 1, the process of preparing the compound of Formula 4 includes the step of preparing the compound of Formula 1 from the compound of Formula 2 by the method disclosed above. Also disclosed is compound that is methyl 3,5-dichlorobenzeneethanimidate methyl 3,5-dichlorobenzeneethanimidate or ethyl 3,5-dichlorobenzeneethanimidate or salts thereof.
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5.发明授权PROCESS FOR TRANSITION METAL-CATALYZED ASYMMETRIC HYDROGENATION OF ACRYLIC ACID DERIVATIVES, AND A NOVEL CATALYST SYSTEM FOR ASYMMETRIC TRANSITION METAL CATALYSIS 有权方法的过渡金属催化的不对称过渡金属催化丙烯酸衍生物的不对称氢化和新催化剂体系
公开(公告)号：EP1830958B1
公开(公告)日：2011-03-09
申请号：EP05817279.2
申请日：2005-12-05
发明人： BOOGERS, Jeroen , FELFER, Ulfried , KOTTHAUS, Martina , DE VRIES, Andreas, H., M. , DE VRIES, Johannes, G. , LEFORT, Laurent , STEINBAUER, Gerhard
CPC分类号： C07C51/36 , B01J31/1865 , B01J31/187 , B01J31/24 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07C67/303 , C07C57/36 , C07C57/58 , C07C53/128 , C07C59/64
摘要： A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.
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