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公开(公告)号：EP1855713B1
公开(公告)日：2016-04-27
申请号：EP05856779.3
申请日：2005-06-01
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5254 , A61K2039/5256 , C12N15/86 , C12N2760/16332 , C12N2760/16343 , C12N2760/16345 , C12N2760/16361 , C12N2810/6072
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公开(公告)号：EP1855713A4
公开(公告)日：2009-04-01
申请号：EP05856779
申请日：2005-06-01
IPC分类号： A61K39/00 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/295 , C12N5/00 , C12N15/64
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5254 , A61K2039/5256 , C12N15/86 , C12N2760/16332 , C12N2760/16343 , C12N2760/16345 , C12N2760/16361 , C12N2810/6072
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公开(公告)号：EP1855713A2
公开(公告)日：2007-11-21
申请号：EP05856779.3
申请日：2005-06-01
申请人： MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK , The University of Kentucky Research Foundation
IPC分类号： A61K39/00 , A61K39/295 , A61K39/12 , A61K39/145 , C12N15/64 , C12N5/00 , A61K39/116
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5254 , A61K2039/5256 , C12N15/86 , C12N2760/16332 , C12N2760/16343 , C12N2760/16345 , C12N2760/16361 , C12N2810/6072
摘要： The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated equine influenza viruses having modifications to an equine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.
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