公开(公告)号：EP0003074A3

公开(公告)日：1980-01-02

申请号：EP78300809

申请日：1978-12-13

申请人： BEECHAM GROUP PLC

发明人： Miller, David ,  Rose, Carl John

IPC分类号： C07C49/84 ,  C07C45/00 ,  C07C45/20 ,  C07C69/95 ,  C07C67/30 ,  C07C69/72 ,  C07C67/03

摘要： The present invention relates to a process for the preparation of 4-(6 1 -methoxy-2'-naphthyl)butan-2-one and to certain compounds for use in that process. British Patent Specification No. 1,474,377 discloses inter alia that 4-(6 1 -methoxy-2 1 -naphthyl)butan-2-one possesses useful anti-inflammatory activity. A particularly favoured process has now been discovered that can be used to produce 4-(6 1 -methoxy-2 1 -naphthyl)butan-2-one in particularly good yield. The present invention provides a process for the preparation of 4-(6 1 -methoxy-2 1 -naphthyl)butan-2-one which process comprises the hydrogenation of a compound of the formula (I):
wherein Ar is a 6-methoxy-2-naphthyl group; X and Y are each hydrogen atoms or together represent a second bond between the carbon atoms to which they are attached; and R is a group such that -CO 2 R represents an ester group convertible by hydrogenation to a C0 2 H group.