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    TYK2 INHIBITORS AND USES THEREOF
    2.
    发明公开
    TYK2 INHIBITORS AND USES THEREOF 审中-公开

    公开(公告)号：EP4461734A2

    公开(公告)日：2024-11-13

    申请号：EP24203208.4

    申请日：2019-10-22

    申请人： Alumis Inc.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07D498/04

    摘要： Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

    CATIONIC LIPID ANALOG, AND COMPOSITION AND USE THEREOF
    6.
    发明公开
    CATIONIC LIPID ANALOG, AND COMPOSITION AND USE THEREOF 审中-公开

    公开(公告)号：EP4461316A1

    公开(公告)日：2024-11-13

    申请号：EP22922990.1

    申请日：2022-02-10

    申请人： Guangzhou Lide Biomedicine Technology Co., Ltd.

    发明人： LIU, Zhijia ,  CHEN, Yongming ,  HE, Zepeng ,  LE, Zhicheng

    IPC分类号： A61K47/18 ,  A61K47/22 ,  A61K48/00 ,  C07D295/13 ,  C07C237/22 ,  C07C231/06

    摘要： A cationic lipid analogue, a composition and a use thereof. An aldehyde, an amine, a carboxylic acid and an isonitrile are adopted as raw materials to synthesize a cationic lipid analogue via the Ugi reaction. The synthesized cationic lipid analogue, together with a sterol, an auxiliary lipid and a polyethylene glycol lipid derivative, further forms a nanoparticle-like lipid composition, which can be used for drug delivery, including the delivery of small molecule drugs, nucleic acid drugs such as mRNA, DNA, siRNA, etc., protein/peptide drugs, and gene editing complexes such as mRNA/sgRNA, Cas9/sgRNA, etc. The nanoparticle-like lipid composition achieves mRNA expressions in different organs of animals through different administration methods, and thus can meet the application requirements of mRNA nucleic acid therapies, nucleic acid vaccines, gene editing, etc.