公开(公告)号：EP4288443A1

公开(公告)日：2023-12-13

申请号：EP22707002.6

申请日：2022-02-08

Applicant: BRIDGESTONE CORPORATION

Inventor： DEDECKER, Mark N. ,  SALAMANT, Walter A.

IPC: C07J53/00 ,  C07J71/00 ,  C08F228/00 ,  C08L7/00

公开(公告)号：EP4251634A1

公开(公告)日：2023-10-04

申请号：EP21827547.7

申请日：2021-11-22

Applicant: Sage Therapeutics, Inc.

Inventor： BLANCO-PILLADO, Maria Jesus

IPC: C07J5/00 ,  C07J7/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C07J53/00 ,  C07J71/00 ,  C07J61/00 ,  C07J73/00 ,  A61P25/00

公开(公告)号：EP3658566B1

公开(公告)日：2023-07-19

申请号：EP18750270.3

申请日：2018-07-19

Inventor： RUSSO, Vincenzo ,  MARINOZZI, Maura ,  CASTRO NAVAS, Francisco Fermin

IPC: C07J9/00 ,  C07J17/00 ,  A61K31/58 ,  A61K31/575 ,  A61P35/00 ,  C07J53/00 ,  C07J71/00

公开(公告)号：EP3990467A1

公开(公告)日：2022-05-04

申请号：EP20743025.7

申请日：2020-06-29

Applicant: Sage Therapeutics, Inc.

Inventor： ROBICHAUD, Albert, Jean ,  SALITURO, Francesco, G. ,  BLANCO-PILLADO, Maria, Jesus ,  LA, Daniel ,  HARRISON, Boyd, L. ,  MORNINGSTAR, Marshall, Lee

IPC: C07J43/00 ,  C07J7/00 ,  C07J1/00 ,  C07J63/00 ,  C07J67/00 ,  A61K31/58 ,  A61K31/57 ,  A61K31/573 ,  A61P25/00 ,  C07J13/00 ,  C07J15/00 ,  C07J21/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00 ,  C07J53/00 ,  C07J71/00 ,  C07C13/00

公开(公告)号：EP3858848A1

公开(公告)日：2021-08-04

申请号：EP20878033.8

申请日：2020-11-17

Applicant: Hunan Huacheng Biotech, Inc

Inventor： HUANG, Huaxue ,  LIU, Genggui ,  HE, Anle ,  ZENG, Runqing

IPC: C07J53/00

Abstract: The present invention provides a method for preparing oryzanol from oryzanol-containing soapstock serving as a raw material, comprising the following steps: 1) alkali-alcohol thermal dissolution; 2) heat-preserved fine filtration; 3) heat-preserved ultrafiltration membrane separation; 4) heat-preserved decolourisation; 5) acid neutralisation and filtration; 6) washing; and 7) drying. The temperatures of the step 1) to the step 4) are controlled at 50-60°C. The present invention has the characteristics that the method comprises a heat preservation operation at 50-60°C, membrane separation, decolourisation and washing, to finally prepare a white powdered product, and effects that the purity of oryzanol is greater than 98% and the yield is greater than 73% are achieved. The present invention does not use toxic or combustible or explosive organic solvents such as methanol, ether, hexane and solvent oil, so that the product use safety is improved; the production process is simple, has low requirements on production equipment, is easy to operate and realise, and is low in production cost and suitable for industrial production.

公开(公告)号：EP3796900A1

公开(公告)日：2021-03-31

申请号：EP19827166.0

申请日：2019-06-28

Applicant: DFH Therapeutics ,  The United States of America, as represented by The Secretary, Department of Health and Human Services

Inventor： NITZ, Theodore J. ,  WILD, Carl T. ,  MARTIN, David E. ,  FREED, Eric O.

IPC: A61K31/185 ,  A61K31/195 ,  A61K31/58 ,  C07J53/00 ,  C07J63/00

公开(公告)号：EP2984100B1

公开(公告)日：2017-04-05

申请号：EP13726285.3

申请日：2013-04-12

Applicant: Industriale Chimica S.R.L.

Inventor： LENNA, Roberto ,  BARBIERI, Francesco ,  LUONI, Maria Giovanna ,  NOSEDA, Monica

IPC: C07J53/00

CPC classification number: C07J53/008

公开(公告)号：EP2607372B1

公开(公告)日：2015-10-28

申请号：EP11818239.3

申请日：2011-08-19

Applicant: Kao Corporation ,  Tsuno Food Industrial Co., Ltd.

Inventor： HASHIZUME, Kohjiro ,  TSUNO, Takuo ,  KATO, Koji ,  MORITA, Hisahiro

IPC: C07J75/00 ,  C07J53/00 ,  A61K31/56 ,  A61P3/06 ,  A61P3/10 ,  C07J63/00 ,  C11B3/00

CPC classification number: C07J53/004 ,  C07J9/00 ,  C07J53/00 ,  C07J63/008 ,  C11B3/006 ,  C11C3/06

公开(公告)号：EP2432799B1

公开(公告)日：2014-09-10

申请号：EP10723079.9

申请日：2010-05-20

Applicant: Pierre Fabre Médicament ,  Centre National de la Recherche Scientifique (CNRS)

Inventor： LONG, Christophe ,  GUMINSKI, Yves ,  DERGUINI, Fadila ,  BECK, Joséphine ,  CANTAGREL, Frédéric

IPC: C07J53/00 ,  C07J71/00 ,  A61K31/58 ,  A61K31/575 ,  A61P35/00

CPC classification number: C07J53/004 ,  C07J71/0005

公开(公告)号：EP2755990A1

公开(公告)日：2014-07-23

申请号：EP12832504.0

申请日：2012-09-07

Applicant: Stora Enso Oyj ,  Koskimies, Salme

Inventor： TULISALO, Jukka ,  WICKHOLM, Niko ,  PIRTIMAA, Minni ,  ALAKURTTI, Sami ,  YLI_KAUHAULUOMA, Jari

IPC: C07J63/00 ,  C07J53/00

CPC classification number: C07J63/008

Abstract: The present invention relates to a method for preparation of betulinic acid from betulin. The method comprises oxidizing betulin to betulinic and/or betulonic aldehyde with a ruthenium based catalyst catalyzed oxidation process in the presence of an oxidant, and further converting the betulinic and/or betulonic aldehyde to betulinic acid.