公开(公告)号：EP3864022B1

公开(公告)日：2023-09-20

申请号：EP19797472.8

申请日：2019-10-11

Inventor： BLANCO-PILLADO, Maria, Jesus ,  SALITURO, Francesco, G. ,  MORNINGSTAR, Marshall, Lee

IPC: C07J7/00 ,  C07J43/00 ,  A61K31/57 ,  A61K31/58 ,  A61P25/00 ,  A61P25/24 ,  C07J1/00 ,  C07J13/00 ,  C07J21/00

公开(公告)号：EP4155314A1

公开(公告)日：2023-03-29

申请号：EP22193689.1

申请日：2016-02-19

Applicant: Sage Therapeutics, Inc.

Inventor： ROBICHAUD, Albert Jean ,  SALITURO, Francesco G. ,  HARRISON, Boyd L. ,  MARTINEZ BOTELLA, Gabriel

IPC: C07J43/00 ,  C07J7/00 ,  A61K31/56 ,  A61K31/58 ,  A61K31/565 ,  A61P25/00 ,  C07J13/00 ,  C07J21/00

Abstract: Described herein are neuroactive steroids of the Formula ( I ):

or a pharmaceutically acceptable salt thereof; wherein R 1 , R 2 , R a , G, X, Y, Z, and n are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：EP3848382A1

公开(公告)日：2021-07-14

申请号：EP21160246.1

申请日：2017-05-18

Applicant: NZP UK Limited

Inventor： WEYMOUTH-WILSON, Alexander, Charles ,  KOMSTA, Zofia ,  WALLIS, Laura ,  DAVIES, Ieuan ,  BATCHELOR, Rhys ,  EVANS, Timothy ,  OTTER, Carl

IPC: C07J71/00 ,  C07J9/00 ,  C07J17/00 ,  C07J33/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C07J13/00 ,  C07J21/00 ,  C07J31/00

Abstract: The invention relates to compounds of general formula (I):

wherein:
, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and Y are as defined herein.
The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease.

公开(公告)号：EP3194417A1

公开(公告)日：2017-07-26

申请号：EP15843046.2

申请日：2015-09-17

Applicant: Prevacus, Inc.

Inventor： LEVY, Daniel E.

IPC: C07J13/00 ,  C07J21/00 ,  A61K31/56

Abstract: The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.

Abstract translation: 本发明涉及C-20类固醇化合物，其组合物及其用于治疗，最小化和/或预防包括严重TBI，中度TBI和轻度TBI（包括脑震荡）的创伤性脑损伤（TBI）的方法。

公开(公告)号：EP2088865B1

公开(公告)日：2015-10-21

申请号：EP07864003.4

申请日：2007-11-06

Applicant: Jina Pharmaceuticals Inc.

Inventor： AHMAD, Moghis U. ,  ALI, Shoukath M. ,  AHMAD, Ateeq ,  SHEIKH, Saifuddin ,  AHMAD, Imran

IPC: A01N65/00 ,  A61K36/328 ,  C07J7/00 ,  C07J13/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

CPC classification number: C07J13/007 ,  A61K31/337 ,  A61K47/554 ,  A61K47/6907 ,  A61K47/6911 ,  C07J7/0005 ,  C07J31/006 ,  C07J41/0005 ,  C07J41/0088 ,  C07J51/00 ,  C12N15/85

公开(公告)号：EP2407475A2

公开(公告)日：2012-01-18

申请号：EP11181831.6

申请日：2008-06-18

Applicant: Kythera Biopharmaceuticals, Inc.

Inventor： Moriarty, Robert M. ,  David, Nathaniel E. ,  Mahmood, Nadir Ahmeduddin ,  Prasad, Achampeta Rathan ,  Swaringen, Roy A., Jr. ,  Reid, John Gregory ,  Sahoo, Akhila Kumar

IPC: C07J1/00 ,  C07J9/00 ,  C07J13/00 ,  A61K31/575 ,  A61P3/04 ,  A61Q19/06 ,  A61K8/63

CPC classification number: A61K8/63 ,  A61Q19/06 ,  C07J1/0011 ,  C07J1/0022 ,  C07J9/005 ,  C07J13/007

Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

Abstract translation: 胆汁酸和相关组合物及其合成和使用方法。 更具体地，脱氧胆酸和相关组合物，所述组合物不含动物来源的所有部分且不含热原部分。

公开(公告)号：EP2284176A1

公开(公告)日：2011-02-16

申请号：EP10168885.1

申请日：2004-04-24

Applicant: Seoul National University Industry Foundation

Inventor： Kang, Heonjoong ,  Ham, Jungyeob ,  Chin, Jungwook

IPC: C07J13/00 ,  C07J1/00 ,  C07J21/00 ,  C07J33/00 ,  C07J51/00 ,  C07J71/00

CPC classification number: C07J13/007 ,  C07J1/0011 ,  C07J21/006 ,  C07J31/006 ,  C07J33/007 ,  C07J71/001 ,  C07J75/00

Abstract: The present invention relates to a method for selective preparing 4,17 (20)- E -pregnadiene-3,16-dione ( E -guggulsterone) of the formula (III) and 4,17 (20)- Z -pregnadiene-3,16-dione ( Z -guggulsterone) of the formula (IV) having an effect of lowering the elevated low density lipoprotein (LDL) and high levels of the cholesterol effectively, and elevating the low levels of the high density lipoprotein (HDL) from a easy-available steroid of the following formula (I).
Also, the present invention provides a method for preparation of the compound of the above formula (II).

公开(公告)号：EP2239320A1

公开(公告)日：2010-10-13

申请号：EP09705123.9

申请日：2009-01-29

Applicant: Kyowa Hakko Kirin Co., Ltd.

Inventor： ONODERA, Hideyuki c/o Med. Chem. Res. Lab. ,  ICHIMURA, Michio c/o Kyowa, Medex Research Lab ,  BABA, Kouji, c/o Tokyo Branch ,  AGATSUMA, Tsutomu c/o Med. Chem. Res. Lab. ,  SASHO, Setsuya c/o Head Office, Kyowa Hakko Kirin Co Ltd. ,  Susuki, Makoto c/o Kyowa Wellness, Co Ltd ,  IWAMOTO, Susumu c/o Med. Chem. Res. Lab., ,  KAKITA, Shingo c/o Pharmacokinetic Res. Lab.

IPC: C12N5/06 ,  A61K35/74 ,  A61P25/00 ,  A61P43/00 ,  C07D487/22 ,  C07D491/22 ,  C07D519/00 ,  C07J13/00 ,  C07J71/00 ,  C07J73/00 ,  C12P17/18 ,  C12P33/00

CPC classification number: C07J73/003 ,  A61K38/00 ,  C07D487/22 ,  C07D491/22 ,  C07D519/00 ,  C07J9/00 ,  C07J71/0005 ,  C07J71/001 ,  C12N5/0619 ,  C12N5/0623 ,  C12N2501/999 ,  C12P7/62 ,  C12P17/182 ,  C12P17/188 ,  C12P33/00 ,  C12P33/20 ,  C12R1/80

Abstract: A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.

Abstract translation: 用于神经干细胞的增殖促进剂，其包含由青霉菌产生的化合物。 CND1007（FERM BP-10917）或其药学上可接受的盐作为活性成分; 由青霉菌产生的新型化合物 CND1007或其药学上可接受的盐; 一种用于产生神经干细胞的方法，其包括在存在由青霉菌产生的化合物的情况下培养神经干细胞以增殖神经干细胞。 CND1007或其药学上可接受的盐，并从培养物中收获神经干细胞; 等等。

公开(公告)号：EP1020191B1

公开(公告)日：2008-12-24

申请号：EP99302556.8

申请日：1999-03-31

Applicant: Council of Scientific and Industrial Research

Inventor： Pratap, Ram ,  Gupta, Ram Chandra ,  Chander, Ramesh ,  Khanna, Ashok Kumar ,  Srivastava, Arvind Kumar ,  Raina, Deepak ,  Singh, Satyavan ,  Srivastava, Savita ,  Rastogl, Anil Kumar ,  Asthana, Omkar Prasad ,  Nityanand, Swarna ,  Anand, Nitya ,  Ghatak, Ashim ,  Kapoor, Narinder Kumar ,  Dev, Sukh

IPC: A61K31/57 ,  C07J13/00 ,  C07J7/00 ,  A61P3/10 ,  A61P3/06

CPC classification number: A61K31/573 ,  C07J13/005 ,  C07J13/007

公开(公告)号：EP1945654A2

公开(公告)日：2008-07-23

申请号：EP06805540.9

申请日：2006-10-30

Applicant: LEO PHARMA A/S

Inventor： JENSEN, Jan ,  ANDERSEN, Niels, Rastrup

IPC: C07J13/00 ,  A61K31/575 ,  A61P31/00

CPC classification number: C07J13/007

Abstract: The present invention relates to processes for the crystallisation and for the preparation and isolation of a novel crystalline form of fusidic acid, to the use of said processes in the manufacture of pharmaceutical formulation or medicament, and to the use of said crystalline fusidic acid form for the treatment of bacterial infections.