公开(公告)号：EP4504747A1

公开(公告)日：2025-02-12

申请号：EP23781859.6

申请日：2023-03-31

Applicant: National Taiwan University

Inventor： LIANG, Pi-Hui

IPC: C07J63/00 ,  C07J75/00

公开(公告)号：EP4397366A3

公开(公告)日：2024-11-20

申请号：EP24159204.7

申请日：2018-08-06

Applicant: Ardelyx, Inc.

Inventor： LUEHR, Gary ,  DRAGOLI, Dean ,  LEADBETTER, Michael ,  CHEN, Tao ,  LEWIS, Jason

IPC: C07J63/00 ,  A61K31/575 ,  A61P3/12 ,  A61P7/08

Abstract: The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R 1 , R 2 , R 3 and R 4 , are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia.

公开(公告)号：EP3661945B1

公开(公告)日：2024-04-03

申请号：EP18759491.6

申请日：2018-08-06

Inventor： LUEHR, Gary ,  DRAGOLI, Dean ,  LEADBETTER, Michael ,  CHEN, Tao ,  LEWIS, Jason

IPC: C07J63/00 ,  A61K31/575 ,  A61P5/44

公开(公告)号：EP4248960A3

公开(公告)日：2024-01-03

申请号：EP23190310.5

申请日：2020-02-11

Applicant: Hetero Labs Limited

Inventor： BANDI, Parthasaradhi Reddy ,  KURA, Rathnakar Reddy ,  ABDULLA, Panduranga Reddy ,  KASIREDDY, Bhaskar Reddy

IPC: C07J63/00 ,  A61K31/58 ,  A61P31/18 ,  A61K31/18

Abstract: The present invention relates to novel triterpene derivatives of formula (I); and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , and ring

are as defined herein. The invention also relates to novel triterpene derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

公开(公告)号：EP3686212B1

公开(公告)日：2023-11-01

申请号：EP18856706.9

申请日：2018-09-17

Inventor： NAN, Fajun ,  XIE, Xin ,  XIE, Cen ,  ZHANG, Chenlu ,  LIU, Yameng ,  GUO, Shimeng ,  ZHANG, Yangming ,  WANG, Siwei

IPC: C07J63/00 ,  A61K31/56 ,  A61K31/58 ,  A61P3/00 ,  A61P1/16 ,  A61P3/06 ,  A61P3/10

公开(公告)号：EP4234016A3

公开(公告)日：2023-10-18

申请号：EP23164821.3

申请日：2020-02-06

Applicant: Ardelyx, Inc.

Inventor： DRAGOLI, Dean ,  LUEHR, Gary ,  CHEN, Tao ,  LEWIS, Jason ,  LEADBETTER, Michael

IPC: C07J63/00 ,  A61K31/56 ,  A61P5/40 ,  A61P9/00

Abstract: The present invention provides a compound of formula (I) or a salt thereof:

wherein X, L, V, R 1 , R 2 , R 3 and R 4 , are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) and as a result are useful in the treatment of hyperkalemia by preventing cortisol from being oxidised to cortisone and thus allowing it to occupy the mineralocorticoid receptor, thus stimulating potassium excretion

公开(公告)号：EP4015003B1

公开(公告)日：2023-05-10

申请号：EP21212184.2

申请日：2019-12-09

Inventor： POSTEL, Ruben ,  FUCHS, Hendrik

IPC: A61K47/55 ,  A61K47/68 ,  A61P35/00 ,  A61K47/54 ,  A61K39/00 ,  C07J63/00 ,  C07K16/32 ,  C07H15/256

公开(公告)号：EP3389669B1

公开(公告)日：2023-03-15

申请号：EP16876910.7

申请日：2016-12-19

Inventor： TAN, Derek S. ,  GIN, David Y. ,  WALKOWICZ, William E. ,  FERNANDEZ-TEJADA, Alberto ,  RAGUPATHI, Govindaswami

IPC: C07J63/00 ,  A61K31/7024

公开(公告)号：EP3990468A1

公开(公告)日：2022-05-04

申请号：EP20743477.0

申请日：2020-06-29

Applicant: Sage Therapeutics, Inc.

Inventor： BLANCO-PILLADO, Maria, Jesus ,  SALITURO, Francesco, G. ,  MORNINGSTART, Marshall, Lee

IPC: C07J43/00 ,  C07J63/00 ,  A61K31/58 ,  A61K31/56 ,  A61P25/00 ,  C07J1/00 ,  C07J7/00 ,  C07J9/00 ,  C07J17/00 ,  C07J21/00 ,  C07J41/00

公开(公告)号：EP3990467A1

公开(公告)日：2022-05-04

申请号：EP20743025.7

申请日：2020-06-29

Applicant: Sage Therapeutics, Inc.

Inventor： ROBICHAUD, Albert, Jean ,  SALITURO, Francesco, G. ,  BLANCO-PILLADO, Maria, Jesus ,  LA, Daniel ,  HARRISON, Boyd, L. ,  MORNINGSTAR, Marshall, Lee

IPC: C07J43/00 ,  C07J7/00 ,  C07J1/00 ,  C07J63/00 ,  C07J67/00 ,  A61K31/58 ,  A61K31/57 ,  A61K31/573 ,  A61P25/00 ,  C07J13/00 ,  C07J15/00 ,  C07J21/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00 ,  C07J53/00 ,  C07J71/00 ,  C07C13/00