CELL CULTURE BASE MATERIAL FOR SERUM-FREE MEDIUM

    公开(公告)号:EP4368700A1

    公开(公告)日:2024-05-15

    申请号:EP22837668.7

    申请日:2022-07-05

    IPC分类号: C12N5/071 C08F20/34 C12M1/00

    CPC分类号: C08F20/34 C12N5/06 C12M1/00

    摘要: Objects of the present invention are to provide a base film for cell culture that enables mass production of homogeneous and high-quality cell aggregates even without the use of a biological serum, and to provide a base film-forming agent for forming the base film, and a substrate for producing cell aggregate. The present inventors provide a base film-forming agent for cell culture including a polymer, a cell adhesive substance, and a solvent, wherein the polymer contains a repeating unit derived from a monomer of formula (I) below:

    wherein Ua1, Ua2, Ra1, and Ra2 are as described in the specification and the claims.

    SANITARY PRODUCT AND AGENT FOR TREATING SANITARY PRODUCT

    公开(公告)号:EP3231451A4

    公开(公告)日:2018-07-11

    申请号:EP15867040

    申请日:2015-12-08

    申请人: KAO CORP

    摘要: A water-soluble cationic polymer is applied to a sanitary product. The water-soluble cationic polymer has a structure including a main chain and a side chain bound to the main chain and has a molecular weight of 2000 or more. The water-soluble cationic polymer is a quaternary ammonium salt homopolymer or a quaternary ammonium salt copolymer. In the water-soluble cationic polymer, the main chain and the side chain are bound to each other at one point, and the side chain has a quaternary ammonium moiety. It is preferable that the quaternary ammonium salt homopolymer has a molecular weight of ten million or less. It is preferable that the quaternary ammonium salt copolymer is a copolymer of a polymerisable monomer having a quaternary ammonium moiety and a cationic polymerisable monomer, an anionic polymerisable monomer, or a nonionic polymerisable monomer, and has a molecular weight of ten million or less.

    SANITARY PRODUCT AND AGENT FOR TREATING SANITARY PRODUCT
    8.
    发明公开
    SANITARY PRODUCT AND AGENT FOR TREATING SANITARY PRODUCT 审中-公开
    卫生产品和治疗卫生产品的代理商

    公开(公告)号:EP3231451A1

    公开(公告)日:2017-10-18

    申请号:EP15867040.6

    申请日:2015-12-08

    申请人: Kao Corporation

    摘要: A water-soluble cationic polymer is applied to a sanitary product. The water-soluble cationic polymer has a structure including a main chain and a side chain bound to the main chain and has a molecular weight of 2000 or more. The water-soluble cationic polymer is a quaternary ammonium salt homopolymer or a quaternary ammonium salt copolymer. In the water-soluble cationic polymer, the main chain and the side chain are bound to each other at one point, and the side chain has a quaternary ammonium moiety. It is preferable that the quaternary ammonium salt homopolymer has a molecular weight of ten million or less. It is preferable that the quaternary ammonium salt copolymer is a copolymer of a polymerisable monomer having a quaternary ammonium moiety and a cationic polymerisable monomer, an anionic polymerisable monomer, or a nonionic polymerisable monomer, and has a molecular weight of ten million or less.

    摘要翻译: 水溶性阳离子聚合物应用于卫生产品。 水溶性阳离子聚合物具有包含主链和与主链结合的侧链的分子量为2000以上的结构。 水溶性阳离子聚合物是季铵盐均聚物或季铵盐共聚物。 在水溶性阳离子聚合物中,主链和侧链在一点彼此结合,并且侧链具有季铵部分。 季铵盐均聚物的分子量优选为1000万以下。 季铵盐共聚物优选为具有季铵部分的可聚合单体和阳离子可聚合单体,阴离子可聚合单体或非离子可聚合单体的共聚物,并且具有一千万或更少的分子量。

    Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom
    10.
    发明公开
    Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom 审中-公开
    具有单体的多个阳离子基团,其制备过程,并且具有从衍生的聚合物单元

    公开(公告)号:EP2644592A1

    公开(公告)日:2013-10-02

    申请号:EP13171324.0

    申请日:2003-06-03

    申请人: RHODIA INC.

    发明人: Liu, Leo Zhaoqing

    摘要: Monomer compounds comprising several cationic groups are provided. The invention also relates to a process for making these monomer compounds. The process is highly selective and prevents unwanted reactions leading to undesired structures. The invention relates also to polymers, including copolymers, comprising units deriving from said monomer compounds. The monomer compounds comprise several cationic groups, e.g. those having the following formula (I): wherein -R 1 is a hydrogen atom, a methyl group or an ethyl group, - A, which is identical or different, is a group comprising an ester group of formula -A-C(O)-O-A 2 -, or an amide group of formula -A 1 -C(O)-NR 10 -A 2 -, wherein: -R 10 , which is identical or different, is hydrogen or an alkyl, hydroxyalkyl, or aminoalkyl C 1 -C 6 linear or branched group - A 1 , which is identical or different is a covalent bond or a group of formula -(CH 2 ) P1 - wherein p1 is an integer of from 1 to 6, preferably 1, -A 2 , which is identical or different, is a linear or branched hydrocabron group comprising optionally N, O, or S hereroatomes or heterogroups, optionally substituted, optionally forming or comprising a cycle, such as a heterocycle, A 2 preferably being a group of formula -(CH 2 ) p2 - wherein p 2 is an integer of from 1 to 6, - R 1 , R 2 , R 3 , R 5 and R 6 , which are identical or different, are hydrogen, alkyl, hydroxyalkyl, or aminoalkyl C 1 -C 6 linear or branched groups, or, if inside the brackets, form a heterocycle with group A 2 , -m is an integer of from 1 to 10, preferably of from 1 to 2, - n is an integer of from 1 to 6, preferably 2 or 4, Z is -O-, -C(O)O, or -C(O)NH-, B is linear or branched C 2 -C 12 polymethylene chain, preferably a C 3 -C 6 one, optionally comprising heteroatoms or heterogroups, such as O or NH, and optionally substituted with one or several hydroxy or amino groups, and -X - , which are identical or different, are counter ions.

    摘要翻译: 提供了包含多个阳离子基团的单体化合物。 因此,本发明涉及用于制备合成的单体化合物的方法。 该过程是高度选择性的,并且防止不希望的反应,导致不希望的结构。 本发明涉及到这样的聚合物,包括共聚物,包括从所述单体化合物衍生的单元。 单体化合物包括几个阳离子基团,例如 那些具有下式(I):其中R 1是氢原子,在,甲基或乙基 - A,这是相同的或不同的,是包括在式-A-C(O)的酯基的基团 - OA 2 - ,或酰胺基团的式-A 1 -C(O)NR 10 -A 2 - , - worin:-R 10,其是相同或不同的,是氢或烷基,羟基烷基,氨基烷基或C 1 -C 6直链或支链基团 - A 1,这是相同或不同的为共价键或下式基团 - (CH 2)P1 - worin p1为1〜6的整数,优选为1,-A 2, 其是相同或不同的,是直链或支链的hydrocabron团包括,可选择地N,O,或S赫雷罗原子或杂基团,任选地substituiertem,任选形成或包含一个周期,检查作为杂环,A2优选为式的基团 - ( CH 2)p2的 - worin p 2是从1至6的整数, - R 1,R 2,R 3,R 5和R 6,可以相同或不同,是氢,烷基,羟烷基,氨基烷基或C 1 -C 6直链或支链基团,或者,如果括号内,形成具有基团A 2的杂环,-m是1至10的整数,优选从1到2 - ,n为1的整数 至6,优选2或4,Z是-O - , - C(O)O,或-C(O)NH-,B是直链或支链的C 2 -C 12聚亚甲基链,优选为C 3 -C 6 一个,任选地包含杂原子或杂基团,:如O或NH,和与一个或几个羟基或氨基,和X OPTIONALLY substituiertem - ,相同或不同,是抗衡离子。