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    CELL CULTURE SCAFFOLD MATERIAL
    3.
    发明公开
    CELL CULTURE SCAFFOLD MATERIAL 审中-公开

    公开(公告)号：EP4458948A1

    公开(公告)日：2024-11-06

    申请号：EP22916003.1

    申请日：2022-12-26

    申请人： SEKISUI CHEMICAL CO., LTD.

    发明人： ARAI, Yuuhei ,  NAKAJIMA, Nami

    IPC分类号： C12M3/00 ,  C07K5/09 ,  C07K5/10 ,  C07K5/11 ,  C07K7/06 ,  C07K17/08 ,  C08F261/12 ,  C08G81/02 ,  C08L101/06 ,  C12M1/00 ,  C12N1/00 ,  C12N5/071

    摘要： Provided is a scaffold material for cell culture with which the culture stability of cells can be maintained over an extended period of time. A scaffold material for cell culture according to the present invention contains a peptide-conjugated (meth)acrylic copolymer having a (meth)acrylic copolymer moiety and a peptide moiety bonded to the (meth)acrylic copolymer moiety, the following relaxation time (CS 2 ) being 5 milliseconds or less. Relaxation time (CS 2 ): a relaxation time of a CS component, which is a component having the lowest molecular mobility among three components, when the scaffold material for cell culture after being brought into contact with heavy water at 25°C for 18 hours is measured by a CPMG method using pulsed NMR, and the obtained free induction decay curve of spin-spin relaxation of 1 H is separated into three components.

    SCAFFOLD MATERIAL FOR CELL CULTURE
    4.
    发明公开
    SCAFFOLD MATERIAL FOR CELL CULTURE 审中-公开

    公开(公告)号：EP4458946A1

    公开(公告)日：2024-11-06

    申请号：EP22916001.5

    申请日：2022-12-26

    申请人： SEKISUI CHEMICAL CO., LTD.

    发明人： ARAI, Yuuhei ,  KOBAYASHI, Daigo ,  ARAI, Yoshito

    IPC分类号： C12M3/00 ,  C07K5/09 ,  C07K5/10 ,  C07K5/11 ,  C07K7/06 ,  C07K17/08 ,  C08F261/12 ,  C08G81/02 ,  C08L101/06 ,  C12M1/00 ,  C12N1/00 ,  C12N5/071

    摘要： Provided is a scaffold material for cell culture with which the culture stability of cells can be maintained over an extended period of time. A scaffold material for cell culture according to the present invention contains a peptide-conjugated (meth)acrylic copolymer having a (meth)acrylic copolymer moiety and a peptide moiety bonded to the (meth)acrylic copolymer moiety, when the peptide-conjugated (meth)acrylic copolymer is subjected to high performance liquid chromatography measurement under the following condition 1, a peak top of a main peak having the largest area among signals being not detected within a retention time of 4 minutes:
    the condition 1 being:
    a column of C18 (Inner diameter 3.0 mm × length 150 mm, filler particle size 3.5 µm),
    a column temperature of 40°C,
    a flow rate of 0.3 mL/min,
    a detector of an evaporative light scattering detector,
    a mobile phase A (liquid A) of a 0.1 wt% aqueous formic acid solution,
    a mobile phase B (liquid B) of isopropyl alcohol,
    a retention time of 0 minutes, in which the liquid A/the liquid B (volume ratio) is 70%/30%,
    a retention time of 0 minutes to 15 minutes, in which the liquid A/the liquid B (volume ratio) is changed from 70%/30% to 0%/100%, and
    a retention time of 15 minutes to 30 minutes, in which the liquid A/the liquid B (volume ratio) = 0%/100% is maintained

    SCAFFOLD MATERIAL FOR CELL CULTURE
    5.
    发明公开
    SCAFFOLD MATERIAL FOR CELL CULTURE 审中-公开

    公开(公告)号：EP4458945A1

    公开(公告)日：2024-11-06

    申请号：EP22916000.7

    申请日：2022-12-26

    申请人： SEKISUI CHEMICAL CO., LTD.

    发明人： ARAI, Yuuhei ,  KOBAYASHI, Daigo

    IPC分类号： C12M3/00 ,  C07K5/09 ,  C07K5/10 ,  C07K5/11 ,  C07K7/06 ,  C07K17/08 ,  C08F261/12 ,  C08G81/02 ,  C08L101/06 ,  C12M1/00 ,  C12N1/00 ,  C12N5/071

    摘要： Provided is a scaffold material for cell culture with which the culture stability of cells can be maintained over an extended period of time. A scaffold material for cell culture according to the present invention contains a peptide-conjugated (meth)acrylic copolymer having a (meth)acrylic copolymer moiety and a peptide moiety bonded to the (meth)acrylic copolymer moiety, the (meth)acrylic copolymer moiety having a structural unit derived from a (meth)acrylate compound (A) represented by the following Formula (A1) or the following Formula (A2), and a content ratio of the structural unit derived from the (meth)acrylate compound (A) being 25 mol% or more and 98 mol% or less in 100 mol% of the total structural units of the (meth)acrylic copolymer moiety. In the Formula (A1), R represents a hydrocarbon group having 2 or more and 18 or less carbon atoms. In the Formula (A2), R represents a hydrocarbon group having 2 or more and 18 or less carbon atoms.

    SYSTEMS AND METHODS FOR TISSUE PROCESSING AND PREPARATION OF CELL SUSPENSION THEREFROM
    9.
    发明公开
    SYSTEMS AND METHODS FOR TISSUE PROCESSING AND PREPARATION OF CELL SUSPENSION THEREFROM 审中-公开

    公开(公告)号：EP4455258A2

    公开(公告)日：2024-10-30

    申请号：EP24199321.1

    申请日：2014-03-14

    申请人： AVITA Medical Americas, LLC

    发明人： QUICK, Andrew Perry ,  FENCIL, David Allen ,  DOLPHIN, William Ford

    IPC分类号： C12M1/00

    摘要： The present invention provides for methods and at least partially automated devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. Tissue regeneration in humans is extremely limited and constitutes a major challenge to the repair of damaged organ function. Wound treatment is a typical area where tissue regeneration is required. Wounds (lacerations or openings) in mammalian tissue can result in tissue disruption and coagulation of the microvasculature at the wound face.