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    A SYSTEM AND METHOD FOR GENERATING A GRAPHICAL MODEL
    2.
    发明公开
    A SYSTEM AND METHOD FOR GENERATING A GRAPHICAL MODEL 审中-公开

    公开(公告)号：EP3770920A1

    公开(公告)日：2021-01-27

    申请号：EP20187789.1

    申请日：2020-07-24

    申请人： Babylon Partners Limited

    发明人： LEE, Ciarán Mark ,  DHIR, Anish

    IPC分类号： G16H50/20 ,  G16B5/10

    摘要： A computer implemented method of creating a model that is a graphical representation comprising:
    receiving, a first dataset comprising a first variable and a third variable and a second dataset comprising a second variable and the third variable;
    creating graphical representations of the first dataset and the second dataset by applying conditional independence tests on the first dataset and second dataset;
    storing conditional independence information obtained by applying the conditional independence tests on the first dataset and the second dataset;
    applying a bivariate causal discovery algorithm to determine a causal relation between the first and third variable in the first dataset and a causal relation between the second and third variable in the second dataset, the causal discovery algorithm being able to determine if the first variable causes the third variable, the third variable causes the first variable, the second variable causes the third variable and the third variable causes the second variable;
    modifying the graphical representations of the first and second dataset according to the determined causal relations; and
    creating a set of candidate graphical representations for a third dataset comprising the first dataset and the second dataset, wherein each candidate graphical representation is consistent with the conditional independence information.

    PROGNOSTIC PATHWAYS FOR VIRAL INFECTIONS
    5.
    发明公开
    PROGNOSTIC PATHWAYS FOR VIRAL INFECTIONS 审中-公开

    公开(公告)号：EP3978628A1

    公开(公告)日：2022-04-06

    申请号：EP20199615.4

    申请日：2020-10-01

    申请人： Koninklijke Philips N.V.

    发明人： VAN DE STOLPE, Anja ,  BOUWMAN, Wilbert Hendrik

    IPC分类号： C12Q1/6883 ,  G16B5/10

    摘要： The invention relates to a method for determining whether a subject with an infection has a viral infection. The invention further relates to method for determining the cellular immune response to a viral infection or a vaccine. The methods may be performed on a blood sample obtained from a subject, and is based on the finding that specific cellular signaling pathways are active. The invention further relates to components for performing the methods and use of those components in a method of diagnosis.

    A METHOD TO PREDICT LIFESPAN AND HEALTHSPAN
    9.
    发明公开
    A METHOD TO PREDICT LIFESPAN AND HEALTHSPAN 审中-公开

    公开(公告)号：EP4310858A1

    公开(公告)日：2024-01-24

    申请号：EP22185439.1

    申请日：2022-07-18

    申请人： Leibniz-lnstitut Für Altersforschung ,  Scuola Normale Superiore

    发明人： Cellerino, Alessandro ,  Ferrari, Elisa

    IPC分类号： G16H50/30 ,  G16H50/20 ,  G16B5/10 ,  G16B20/40 ,  G16B25/10 ,  G16B40/20 ,  G16B40/30

    摘要： The invention relates to a method for predicting the lifespan of an individual, comprising i. providing biological input data of the subject, ii. providing a list of confounding variables, iii. predicting an age-related mortality or disease, preferably the time to death and/or the mortality risk and/or the risk of age-related disease, for the subject by analyzing the data with an algorithm, wherein the algorithm comprises a neural network, which is trained on at least one reference dataset comprising biological data of at least one reference subject by applying: a) a selector layer to filter input data of i., and b) an adversarial learning framework, that removes from the input data the information related to the confounding variables, wherein preferably the adversarial learning framework, is a neural network comprising three elements: a feature extractor (FE), a predictor (P), and a confounder predictor (C). The invention further relates to a device or system comprising means for carrying out the steps of the method according to the invention, a computer program [product] and a computer-readable storage medium.