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公开(公告)号：EP3733641B1
公开(公告)日：2024-04-10
申请号：EP18896553.7
申请日：2018-12-27
IPC分类号： C07C229/12 , A61K9/16 , A61K31/7088 , C12N15/88 , A61K31/713 , A61K31/7105 , A61K47/18 , A61K9/127 , A61K48/00 , A61P35/00 , A61P35/02
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公开(公告)号：EP4229030A1
公开(公告)日：2023-08-23
申请号：EP21805568.9
申请日：2021-10-14
发明人： LEBRUN, Xavier
IPC分类号： C07C229/12 , C07C227/18 , C11D1/90
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公开(公告)号：EP4217337A1
公开(公告)日：2023-08-02
申请号：EP21870641.4
申请日：2021-09-23
发明人： KAUR, Harpreet , LIU, Xuejun , NEPAL, Prabin , PARAMANANTHAM, Subakar , GARG, Monika , LI, Zemin , TJENG, Andy , RODRIGUEZ, Moises , JONG, Laura , MIRZAHOSSEIN, Azam , YIFRACH-STAV, Ofer , BASSETT, Erin , RINGUETTE, Randy , CAMPBELL, Charles , KELLY, Melanie
IPC分类号： C07C229/12 , C07C41/06 , C07C41/34 , C07C43/196
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公开(公告)号：EP4165012A1
公开(公告)日：2023-04-19
申请号：EP21714888.1
申请日：2021-03-29
申请人： RHODIA OPERATIONS
IPC分类号： C07C229/12 , C11D1/62
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5.发明公开
公开(公告)号：EP4140577A1
公开(公告)日：2023-03-01
申请号：EP22176264.4
申请日：2019-04-02
发明人： Brazdil, James , Rogness, Donald , Ma, Chi Cheng
IPC分类号： B01J23/46 , B01J21/18 , B01J23/652 , C07C213/02 , C07C227/08 , C07C227/18 , C07C229/22 , C07C229/12 , C07C215/10 , C07C215/08
摘要： Processes are disclosed for synthesizing an α-amino acid or α-amino acid derivative, from a starting compound having a carbonyl functional group (C=O), with hydroxy-substituted carbon atoms at alpha (α) and beta (β) positions, relative to the carbonyl functional group. An α-, β-dihydroxy carboxylic acid or carboxylate is dehydrated to form a dicarbonyl intermediate by transformation of the α-hydroxy group to a second carbonyl group (adjacent a carbonyl group of the starting compound) and removal of the β-hydroxy group. This dicarbonyl intermediate is optionally cracked to form a second dicarbonyl intermediate having fewer carbon atoms but preserving the first and second carbonyl groups. Either or both of the dicarbonyl intermediate and the cracked dicarbonyl intermediate are then reductively aminated.
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公开(公告)号：EP4103550A2
公开(公告)日：2022-12-21
申请号：EP21709859.9
申请日：2021-02-11
发明人： GREEN, G. David , QUINN, Jordan
IPC分类号： C07D207/267 , C07D207/277 , C07D207/40 , C07D261/02 , C07D263/22 , C07D295/185 , C07C229/12 , C07C237/06
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公开(公告)号：EP4097076A1
公开(公告)日：2022-12-07
申请号：EP21706751.1
申请日：2021-01-21
IPC分类号： C07C229/12 , A61Q1/00 , A61Q5/12 , C11D1/10
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公开(公告)号：EP4019506A1
公开(公告)日：2022-06-29
申请号：EP21214089.1
申请日：2014-12-17
申请人： Novartis AG
发明人： BRITO, Luis , CHEN, Delai , GAMBER, Gabriel Grant , GEALL, Andrew , LOVE, Kevin , ZABAWA, Thomas , ZECRI, Frederic
IPC分类号： C07D319/06 , C07D233/60 , C07C219/06 , C07C229/12 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/62 , A61K31/7088
摘要： This invention provides for a compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein R 1 -R 3 , n, p, L 1 and L 2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.-
公开(公告)号：EP3473611B1
公开(公告)日：2021-10-20
申请号：EP18193953.9
申请日：2013-02-22
发明人： Heyes, James , Wood, Mark , Martin, Alan
IPC分类号： C07C271/20 , C07C217/08 , C07C229/12 , A61K38/00 , A61K31/713 , A61P1/16 , A61P31/12 , A61P35/00
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公开(公告)号：EP3872066A1
公开(公告)日：2021-09-01
申请号：EP21159951.9
申请日：2014-12-17
申请人： Novartis AG
发明人： BRITO, Luis , CHEN, Delai , GAMBER, Gabriel Grant , GEALL, Andrew , LOVE, Kevin , ZABAWA, Thomas , ZECRI, Frederic
IPC分类号： C07D205/04 , C07C229/12 , C07C229/38 , C07D265/30 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/15 , A61K31/40 , A61K31/44
摘要： This invention provides for a compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein R 1 -R 4 , n and p are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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