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201 条记录 (耗时 0.022 秒)

    CRYSTAL FORM OF TAFAMIDIS AND PREPARATION METHOD THEREFOR AND USE THEREOF
    5.
    发明公开
    CRYSTAL FORM OF TAFAMIDIS AND PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开

    公开(公告)号：EP4059926A1

    公开(公告)日：2022-09-21

    申请号：EP20886308.4

    申请日：2020-11-12

    申请人： Crystal Pharmaceutical (Suzhou) Co., Ltd.

    发明人： CHEN, Minhua ,  ZHANG, Jing ,  ZOU, Siming

    IPC分类号： C07D263/57 ,  A61K31/423 ,  A61P25/00

    摘要： The present disclosure relates to novel crystalline forms of tafamidis (hereinafter referred to as compound I) and processes for preparation thereof. The present disclosure also relates to pharmaceutical composition containing the novel crystalline forms, use of the novel crystalline forms for preparing drugs treating disease caused by transthyretin-mediated amyloidosis. The crystalline forms of tafamidis of the present disclosure have one or more improved properties compared with crystalline forms of prior art and have significant value for future drug optimization and development.

    COMPOUND HAVING BENZAZOLE RING STRUCTURE, AND ORGANIC ELECTROLUMINESCENT DEVICE
    9.
    发明公开
    COMPOUND HAVING BENZAZOLE RING STRUCTURE, AND ORGANIC ELECTROLUMINESCENT DEVICE 审中-公开

    公开(公告)号：EP3925958A1

    公开(公告)日：2021-12-22

    申请号：EP20755932.9

    申请日：2020-02-12

    申请人： Hodogaya Chemical Co., Ltd.

    发明人： KASE, Kouki ,  KIM, Si-In ,  KIM, Ji-Yung ,  HIRAYAMA, Yuta ,  SURUGA, Kazuyuki ,  HAYASHI, Shuichi

    IPC分类号： C07D413/02 ,  C07D413/10 ,  C07D421/14 ,  C07D471/04 ,  C09K11/06 ,  C07D263/57 ,  H01L51/50

    摘要： An object of the present invention is to provide, as a material for a highly efficient and highly durable organic EL element, an organic compound that has excellent properties, including excellent electron-injecting/transporting capability, hole-blocking capability, and high stability in the form of a thin film. Another object of the present invention is to provide a highly efficient and highly durable organic EL element by using this compound. The present invention focuses on the properties of the benzazole ring, which has affinity for electrons, and specifically focuses on the capability of its nitrogen atom to coordinate to a metal and also on excellent heat resistance. The inventors have thus designed and chemically synthesized various compounds having a benzazole ring structure, and then experimentally produced organic EL elements including the compounds, followed by thoroughly evaluating the characteristics thereof. As a result, it has been found that it is possible to obtain an organic EL element having excellent properties by using a specific compound having a benzazole ring structure.