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8 条记录 (耗时 0.011 秒)

    CARBAPENEM COMPOUNDS, USE THEREOF, AND INTERMEDIATE COMPOUNDS OF THE SAME
    2.
    发明授权
    CARBAPENEM COMPOUNDS, USE THEREOF, AND INTERMEDIATE COMPOUNDS OF THE SAME 失效
    碳青霉烯类，使用和中级FOR

    公开(公告)号：EP0987267B1

    公开(公告)日：2003-05-07

    申请号：EP98901108.5

    申请日：1998-02-02

    申请人： Kyoto Pharmaceutical Industries, Ltd.

    发明人： MATSUI, Hiroshi ,  KASAI, Masayasu

    IPC分类号： C07D487/04 ,  A61K31/40 ,  C07D477/10 ,  C07D477/12 ,  C07D477/20 ,  A61P31/04

    CPC分类号： C07D477/20 ,  A61K31/407 ,  Y02P20/55

    摘要： Carbapenem compounds represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein each symbol has the meaning as defined in the specification. Because of being excellent in absorbability in the digestive tract when administered orally and showing sufficient antimicrobial activities over a broad scope of microorganisms, these compounds (I) or pharmaceutically acceptable salts thereof are highly useful as preventives and remedies for infectious diseases, in particular, microbisms. These preventives and remedies are usable in preventing and treating diseases caused by bacteria such as purulent diseases, respiratory infection, biliary infection, and urinary tract infection in warm-blooded animals including human being, dog, cat, cow, horse, rat and mouse.

    BETA-LACTAM ANTIBIOTICS, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
    6.
    发明公开
    BETA-LACTAM ANTIBIOTICS, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS 失效
    BETA-LACTAM抗生素，其制备方法及其在药物组合物中的应用

    公开(公告)号：EP0059554A3

    公开(公告)日：1982-10-20

    申请号：EP82300798

    申请日：1982-02-17

    申请人： BEECHAM GROUP PLC

    发明人： COULTON, STEVEN

    IPC分类号： C07D477/10 ,  C07D487/04 ,  A61K31/40

    CPC分类号： C07D477/10

    摘要： The present invention relates to carbapenem deriva­ tives, and, in particular, to a novel class of substituted carbapenem derivatives wherein the C-6 substituent is a substituted triazolyl ethyl group.
    The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof:- wherein R¹ is hydrogen, an organic radical or group S(O)
    n R² wherein R² an organic radical and n is zero or one; and A is a divalent two atom radical forming the residue of a five membered ring wherein one of the atoms is optionally substituted carbon and the second atom is an optionally substituted carbon or nitrogen atom.

    摘要翻译： 本发明涉及碳青霉烯衍生物，特别涉及一类新的取代的碳青霉烯衍生物，其中C-6取代基是取代的三唑基乙基。 本发明提供式（I）化合物或其药学上可接受的盐或体内可水解的酯： - 其中R 1是氢，有机基团或基团S（O）n R 2，其中 R 2为有机基团，n为0或1; 并且A是形成五元环的残基的二价二原子基团，其中原子之一是任选取代的碳，第二个原子是任选取代的碳原子或氮原子。