公开(公告)号：EP3140286B1

公开(公告)日：2018-12-26

申请号：EP15789510.3

申请日：2015-05-11

申请人： Biosearch Technologies, Inc.

发明人： REDDINGTON, Mark ,  COOK, Ronald, M. ,  AYER, Ben

IPC分类号： C07D455/04 ,  C07H19/04 ,  C07H19/073 ,  C12Q1/68

CPC分类号： C07D471/06 ,  C07D455/04 ,  C07F9/6561 ,  C07H17/02 ,  C07H21/00 ,  C12Q1/6818

摘要： The present invention provides quenchers of excited state energy, probes and other conjugates comprising these quenchers, and methods of their use.

公开(公告)号：EP3170820A4

公开(公告)日：2017-12-06

申请号：EP15822530

申请日：2015-07-15

申请人： JAPAN SCIENCE & TECH AGENCY

发明人： KANAI MOTOMU ,  SOMA YOHEI ,  TANIGUCHI ATSUHIKO ,  SHIMIZU YUSUKE

IPC分类号： C07D417/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  A61P3/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  C07D455/04 ,  C07K7/06 ,  C07K14/47

CPC分类号： C07D455/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  C07D417/04 ,  C07K7/06 ,  C07K14/47

摘要： It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to A² peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R 1 represents an optionally substituted hydrocarbon group; R 2 represents a hydrogen atom or an optionally substituted hydrocarbon group; R 3 and R 4 are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R 2 and R 4 optionally together form an alkylene group; and R 5 represents an anion.

公开(公告)号：EP3140286A4

公开(公告)日：2017-09-27

申请号：EP15789510

申请日：2015-05-11

申请人： BIOSEARCH TECH INC

发明人： REDDINGTON MARK ,  COOK RONALD M ,  SOWERS BEN

IPC分类号： C07D455/04 ,  C07H19/04 ,  C07H19/073 ,  C12Q1/68

CPC分类号： C07D471/06 ,  C07D455/04 ,  C07F9/6561 ,  C07H17/02 ,  C07H21/00 ,  C12Q1/6818

摘要： The present invention provides quenchers of excited state energy, probes and other conjugates comprising these quenchers, and methods of their use.

摘要翻译： 本发明提供激发态能量的猝灭剂，包含这些猝灭剂的探针和其他缀合物，以及它们的使用方法。

公开(公告)号：EP3071565A1

公开(公告)日：2016-09-28

申请号：EP14864919.7

申请日：2014-11-21

申请人： Auspex Pharmaceuticals, Inc.

发明人： SHAH, Pratik

IPC分类号： C07D455/06 ,  C07C69/96

CPC分类号： A61K31/4745 ,  A61K31/13 ,  A61K31/198 ,  A61K31/4375 ,  A61K31/551 ,  A61K45/06 ,  C07B59/002 ,  C07B2200/05 ,  C07D455/04 ,  A61K2300/00

摘要： Methods for treating abnormal muscular activity are disclosed. The methods may be performed remotely and permit monitoring of a subject outside a healthcare provider's office.

公开(公告)号：EP1667982B1

公开(公告)日：2013-07-31

申请号：EP04788811.0

申请日：2004-09-17

申请人： Merck Sharp & Dohme Corp.

发明人： TROTTER, B. Wesley ,  CLAIBORNE, Christopher ,  PONTICELLO, Gerald, S. ,  MCINTYRE, Charles, J. ,  LIVERTON, Nigel ,  CLAREMON, David, A.

IPC分类号： C07D217/24 ,  C07D221/02 ,  C07D455/04 ,  C07D471/04 ,  A61K31/435 ,  A61K31/47

CPC分类号： C07D217/24 ,  C07D455/04 ,  C07D471/04

公开(公告)号：EP2257551B1

公开(公告)日：2013-04-10

申请号：EP09712156.0

申请日：2009-02-19

申请人： Actelion Pharmaceuticals Ltd.

发明人： HUBSCHWERLEN, Christian ,  RUEEDI, Georg ,  SURIVET, Jean-Philippe ,  ZUMBRUNN ACKLIN, Cornelia

IPC分类号： C07D471/16 ,  C07D498/16 ,  C07D519/00 ,  A61P31/04 ,  A61K31/5415 ,  A61K31/538 ,  A61K31/4745 ,  A61K31/4375 ,  A61K31/437 ,  C07D455/04

CPC分类号： C07D498/16 ,  C07D455/04 ,  C07D471/16 ,  C07D519/00

公开(公告)号：EP0908181B8

公开(公告)日：2009-04-15

申请号：EP97922088.6

申请日：1997-05-19

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： HITTEL, Norbert

IPC分类号： A61K31/473 ,  A61P17/00

CPC分类号： C07D455/04 ,  Y10S514/859

摘要： A remedy for rosacea being efficacious even against intractable rosacea which cannot be completely cured by using remedies comprising antibiotics such as minocycline and having a low toxicity, little side effects and a long-lasting drug effect. The remedy for rosacea contains as the active ingredient at least one compound selected from the group consisting of benzo-heterocyclic derivatives represented by general formula (1) and salts thereof, wherein R represents lower alkyl; and X represents halogeno.

摘要翻译： 一种用于治疗红斑痤疮的药物，即使对抗难治性红斑痤疮也是有效的，其通过使用包含抗生素如米诺环素的治疗剂不能完全治愈，毒性低，副作用小且药物作用持久。 红斑痤疮的治疗剂含有至少一种选自通式（1）代表的苯并杂环衍生物及其盐的化合物作为活性成分，其中R代表低级烷基; X代表卤代。

公开(公告)号：EP0908181B1

公开(公告)日：2009-01-14

申请号：EP97922088.6

申请日：1997-05-19

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： HITTEL, Norbert

IPC分类号： A61K31/473 ,  A61P17/00

CPC分类号： C07D455/04 ,  Y10S514/859

摘要： A remedy for rosacea being efficacious even against intractable rosacea which cannot be completely cured by using remedies comprising antibiotics such as minocycline and having a low toxicity, little side effects and a long-lasting drug effect. The remedy for rosacea contains as the active ingredient at least one compound selected from the group consisting of benzo-heterocyclic derivatives represented by general formula (1) and salts thereof, wherein R represents lower alkyl; and X represents halogeno.

公开(公告)号：EP1175217B1

公开(公告)日：2008-12-03

申请号：EP00939047.7

申请日：2000-05-08

申请人： Wockhardt Limited

发明人： PATEL, M.V. Wockhardt Research Center, ,  GUPTE, S.V. Wockhardt Research Center, ,  CHUGH, Y. Wockhardt Research Center ,  SAOGI, D.G. Wockhardt Research Center, ,  AGARWAL, S.K. Wockhardt Research Center ,  DE SOUZA, N.J. Wockhardt Research Center, ,  KHORAKIWALA, H.F., Wockhardt Research Center

IPC分类号： A61K31/4745 ,  A61P31/04 ,  A61P31/06 ,  C07D455/04

CPC分类号： C07C279/14 ,  A61K31/4745 ,  C07B2200/07 ,  C07D455/04 ,  Y02A50/473

摘要： The present invention relates to S-(-)-optically pure benzoquinolizine carboxylic acid of formula I, and their pharmaceutically acceptable salts, substantially free of their R-(+)-isomers, to processes for their preparation and to pharmaceutical compositions comprising an active compound of the invention. The compounds have excellent antibacterial activity. The compounds and compositions can be used for the treatment of local and systemic bacterial infections, diseases and disorders caused by antibiotic-sensitive and antibiotic-resistant microbial strains, without the concomitant liability of adverse effects associated with the racemic mixture of the active compound of the invention.

公开(公告)号：EP1836193A1

公开(公告)日：2007-09-26

申请号：EP05825515.9

申请日：2005-12-15

申请人： L'Oréal

发明人： DAVID, Hervé ,  GREAVES, Andrew ,  DAUBRESSE, Nicolas

IPC分类号： C07D401/14 ,  C07D401/06 ,  C07D401/12 ,  A61K8/49

CPC分类号： C07D403/14 ,  A61K8/4926 ,  A61K8/4946 ,  A61Q5/065 ,  C07D213/77 ,  C07D401/14 ,  C07D455/04 ,  C09B44/126 ,  C09B44/16

摘要： The invention concerns symmetric diazo cationic compounds of formula (I), their resonance forms, as well as their acid-addition salts and their solvates, wherein W1, identical represent a hydrogen atom, a halogen atom, a -NR5R6, OR7, -NR4-Ph-NR5R6, -NR4-Ph-OR7, -O-Ph-OR7, -O-Ph-NR5R6 group; L represents a cationic of non-cationic linker arm. The invention also concerns dyeing compositions comprising in a suitable medium for dyeing keratinous fibers, such compounds as direct dyeing agent, as well as a method for dyeing keratinous fibers using said composition and a multiple-compartment device.