公开(公告)号：EP3439668B1

公开(公告)日：2024-06-19

申请号：EP17779973.1

申请日：2017-04-10

IPC分类号： A61K31/7048 ,  A61K31/575 ,  A61K47/28 ,  A61K9/12 ,  C12P19/62 ,  C07H17/08 ,  A61P11/10

CPC分类号： A61K47/28 ,  C07H17/08 ,  A61K9/0019 ,  A61K9/007 ,  A61K31/575 ,  A61K31/7048 ,  A61P11/10

公开(公告)号：EP4263504A1

公开(公告)日：2023-10-25

申请号：EP21907956.3

申请日：2021-12-17

申请人： COMPASS Pathfinder Limited

发明人： PROTZKO, Ryan

IPC分类号： C07D209/32 ,  C07D471/04 ,  C07D471/14 ,  C07D487/22 ,  C07H17/02 ,  C07H17/08 ,  C07B45/04 ,  C07B41/12 ,  C07B41/06 ,  A61P25/30 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P25/06

公开(公告)号：EP4118092A1

公开(公告)日：2023-01-18

申请号：EP21716891.3

申请日：2021-03-11

申请人： Zoetis Services LLC

发明人： EWIN, Richard, Andrew ,  COX, Mark, R. ,  HOT, Imelda ,  BEDORE, Matthew, W. ,  RESPONDEK, Tomasz ,  SHEEHAN, Susan, M.K.

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00

公开(公告)号：EP3929203A1

公开(公告)日：2021-12-29

申请号：EP21175661.4

申请日：2016-04-15

申请人： Sfunga Therapeutics, Inc.

发明人： BURKE, Martin D ,  THOTTUMKARA, Arun P ,  MELLEM, Kevin T ,  SWEENEY, Zachary K ,  KOLTUN, Elena S

IPC分类号： C07H17/08 ,  A61P31/04 ,  A61P31/10

摘要： Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas, carbamates, and amides according to Formula (I); C3'-substituted C16 ureas, carbamates, and amides according to Formula (II); C16 acyls according to Formula (III); C2'epi-C16 ureas, carbamates, and amides according to Formula (IV); and C16 oxazolidinone derivatives according to Formula (V). Also disclosed are pharmaceutical compositions comprising the AmB derivatives, and therapeutic methods of using the AmB derivatives.

公开(公告)号：EP3883945A1

公开(公告)日：2021-09-29

申请号：EP19824030.1

申请日：2019-11-18

申请人： Zikani Therapeutics, Inc. ,  President and Fellows of Harvard College

发明人： CLARK, Roger B. ,  ALM, Richard ,  AUSTIN, Wesley Francis ,  GONDI, Vijaya ,  HOGAN, Philip ,  JEWETT, Ivan ,  LAHIRI, Sushmita D. ,  LAWRENCE, Jonathan F. ,  LI, Xiben ,  SHI, Shuhao ,  WANG, Wenying ,  ICHIKAWA, Yoshitaka ,  MYERS, Andrew G. ,  ZHANG, Ziyang ,  CARLSEN, Peter Niels ,  RAHMAN, Md. Ataur

IPC分类号： C07H17/08 ,  C07H15/18 ,  C07H15/26 ,  C07H1/00 ,  A61K31/7048 ,  A61P31/04

公开(公告)号：EP3837270A1

公开(公告)日：2021-06-23

申请号：EP19759306.4

申请日：2019-08-15

申请人： DSM IP Assets B.V.

发明人： DUCHATEAU, Alexander Lucia Leonardus ,  LANKHORST, Peter Philip ,  VAN SCHEPPINGEN, Willebrordus Bernardus

IPC分类号： C07H17/08 ,  C07H1/06

公开(公告)号：EP3412678A1

公开(公告)日：2018-12-12

申请号：EP18167730.3

申请日：2008-01-22

申请人： Merck Sharp & Dohme Corp.

发明人： CHIU, Yu-Hung ,  CHE, Tessie, Mary ,  ROMERO, Alex ,  ICHIKAWA, Yoshi ,  SHUE, Youe-Kong

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (" C . difficile" ) , Clostridium perfringens ( "C. perfringens" ) , Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

公开(公告)号：EP3357908A1

公开(公告)日：2018-08-08

申请号：EP16851632.6

申请日：2016-09-28

申请人： Fujifilm Finechemicals Co., Ltd.

发明人： KEMMOKU, Akira ,  HAGA, Yayoi ,  KAWAMOTO, Fumio

IPC分类号： C07D211/22 ,  C07B41/06 ,  C07B61/00 ,  C07C247/10 ,  C07H17/08

CPC分类号： C07B41/06 ,  B01J19/0093 ,  B01J2219/0086 ,  C07B61/00 ,  C07C247/10 ,  C07D211/22 ,  C07H17/08 ,  Y02P20/55

摘要： A production method for producing an aldehyde compound or a ketone compound by oxidizing a primary or secondary alcohol compound, wherein the alcohol compound has, in the molecule thereof, a group selected from an amino group, an azide group, a hydroxy group and a hydroxy group protected by a protecting group. The method comprises carrying out the reactions of a first step and a second step in succession, wherein the first step comprises collisionally mixing an alcohol compound, a dialkyl sulfoxide having 2 to 8 carbon atoms and an acid anhydride having 4 to 10 carbon atoms with one another in a continuous-flow-type flow reactor to react these components with one another, and the second step comprises collisionally mixing the liquid mixture that has been mixed in the first step with a trialkylamine having 3 to 10 carbon atoms in a continuous-flow-type flow reactor to react these components with each other.

公开(公告)号：EP3344610A1

公开(公告)日：2018-07-11

申请号：EP16766747.6

申请日：2016-09-02

申请人： Agrimetis, LLC

发明人： CALABRESE, Andrew ,  GREEN, Brian Michael ,  SPRING, David R. ,  CASSAYRE, Jerome Yves ,  CONFALONE, Pasquale N.

IPC分类号： C07D313/00 ,  C07H17/08 ,  A01N43/22

摘要： Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described herein include spinosyn derivatives functionalized on the C5-C6 double bond of the spinosyn. The method produces spinosyn derivatives that exhibit activity towards insects, arachnids, and nematodes and are useful in the agricultural and animal health markets.

公开(公告)号：EP3283171A1

公开(公告)日：2018-02-21

申请号：EP16780813.8

申请日：2016-04-15

申请人： Revolution Medicines, Inc.

发明人： BURKE, Martin D. ,  THOTTUMKARA, Arun P. ,  MELLEM, Kevin T. ,  SWEENEY, Zachary K. ,  KOLTUN, Elena S.

IPC分类号： A61P31/10 ,  A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas, carbamates, and amides according to Formula (I); C3′-substituted C16 ureas, carbamates, and amides according to Formula (II); C16 acyls according to Formula (III); C2′epi-C16 ureas, carbamates, and amides according to Formula (IV); and C16 oxazolidinone derivatives according to Formula (V). Also disclosed are pharmaceutical compositions comprising the AmB derivatives, and therapeutic methods of using the AmB derivatives.